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P44469 (PBP2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Penicillin-binding protein 2

Short name=PBP-2
Gene names
Name:mrdA
Synonyms:pbp2
Ordered Locus Names:HI_0032
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cell inner membrane By similarity.

Domain

Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 651651Penicillin-binding protein 2
PRO_0000195448

Sites

Active site3381Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P44469 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4BEB73290952AAB0

FASTA65173,813
        10         20         30         40         50         60 
MNLKKFFNTP THEPFRDKKA ERNLFARRTL VAFLGILLLT GVLFTNIYQL QIVNFDTYQT 

        70         80         90        100        110        120 
RSNGNRIKLL PLPPTRGLIY DRYGKLLAEN LTFFGLYIVP EKTENLDRTL DELRYIVGLT 

       130        140        150        160        170        180 
DNDIENFKKE RRRGTRYTPI LLKPNLTEEQ ISRFAVNGYQ YPSLEVRPYF KRHYLYGETM 

       190        200        210        220        230        240 
AHILGYVGKM NDKDVERLKR EDKFANYAGT NDIGKLGIER YYEDILQGTT GFEEVEINNR 

       250        260        270        280        290        300 
GKVIRTLRSR PAVAGKSIHL TIDLALQRYI TELLSGLKGA VVVLDPKDSS VLAMVSTPSY 

       310        320        330        340        350        360 
DNNLFVDGIS SEDYKRLLND LARPLYSRAT QGAYPPASTV KPFIAVAAQT ENVITPNTTI 

       370        380        390        400        410        420 
FDPGYWVLPN STKRFRDWKK TGHGDTDLNK AITESSDTYF YQVAYNMGID RLSNWMKDFG 

       430        440        450        460        470        480 
FGMPTGIEIQ EETAANIPTR EWKQKRYKRP WVQGDTISVG IGQGYWTATP LQVAKATTIL 

       490        500        510        520        530        540 
VNNGKVNTPH LMKAIEGAVL EPYEDPLLYP DINTPKVAAW EAAKRGMYNV VNAANGTGRK 

       550        560        570        580        590        600 
AFADANYRVA GKSGTAQVFS LKENEKYNTA GLKKELHDHA WFTAYAPYDN PKLVVTVILE 

       610        620        630        640        650 
NAGGGSSNAA PLARKVMDYY LNQRLPQVEK YNVPIQQKKD LSQESEQING R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21710.1.
PIRC64044.
RefSeqNP_438205.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0032.

Chemistry

DrugBankDB00303. Ertapenem.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21710; AAC21710; HI_0032.
GeneID950929.
KEGGhin:HI0032.
PATRIC20188515. VBIHaeInf48452_0032.

Phylogenomic databases

eggNOGCOG0768.
KOK05515.
OMANDGQVKT.
OrthoDBEOG6N0HHV.
PhylomeDBP44469.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03423. pbp2_mrdA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePBP2_HAEIN
AccessionPrimary (citable) accession number: P44469
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names