Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P44469

- PBP2_HAEIN

UniProt

P44469 - PBP2_HAEIN

Protein

Penicillin-binding protein 2

Gene

mrdA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei338 – 3381Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. catalytic activity Source: UniProtKB-KW
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2
    Short name:
    PBP-2
    Gene namesi
    Name:mrdA
    Synonyms:pbp2
    Ordered Locus Names:HI_0032
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651Penicillin-binding protein 2PRO_0000195448Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0032.

    Structurei

    3D structure databases

    ProteinModelPortaliP44469.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    KOiK05515.
    OMAiNDGQVKT.
    OrthoDBiEOG6N0HHV.
    PhylomeDBiP44469.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44469-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLKKFFNTP THEPFRDKKA ERNLFARRTL VAFLGILLLT GVLFTNIYQL    50
    QIVNFDTYQT RSNGNRIKLL PLPPTRGLIY DRYGKLLAEN LTFFGLYIVP 100
    EKTENLDRTL DELRYIVGLT DNDIENFKKE RRRGTRYTPI LLKPNLTEEQ 150
    ISRFAVNGYQ YPSLEVRPYF KRHYLYGETM AHILGYVGKM NDKDVERLKR 200
    EDKFANYAGT NDIGKLGIER YYEDILQGTT GFEEVEINNR GKVIRTLRSR 250
    PAVAGKSIHL TIDLALQRYI TELLSGLKGA VVVLDPKDSS VLAMVSTPSY 300
    DNNLFVDGIS SEDYKRLLND LARPLYSRAT QGAYPPASTV KPFIAVAAQT 350
    ENVITPNTTI FDPGYWVLPN STKRFRDWKK TGHGDTDLNK AITESSDTYF 400
    YQVAYNMGID RLSNWMKDFG FGMPTGIEIQ EETAANIPTR EWKQKRYKRP 450
    WVQGDTISVG IGQGYWTATP LQVAKATTIL VNNGKVNTPH LMKAIEGAVL 500
    EPYEDPLLYP DINTPKVAAW EAAKRGMYNV VNAANGTGRK AFADANYRVA 550
    GKSGTAQVFS LKENEKYNTA GLKKELHDHA WFTAYAPYDN PKLVVTVILE 600
    NAGGGSSNAA PLARKVMDYY LNQRLPQVEK YNVPIQQKKD LSQESEQING 650
    R 651
    Length:651
    Mass (Da):73,813
    Last modified:November 1, 1995 - v1
    Checksum:i4BEB73290952AAB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21710.1.
    PIRiC64044.
    RefSeqiNP_438205.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21710; AAC21710; HI_0032.
    GeneIDi950929.
    KEGGihin:HI0032.
    PATRICi20188515. VBIHaeInf48452_0032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21710.1 .
    PIRi C64044.
    RefSeqi NP_438205.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0032.

    Chemistry

    DrugBanki DB00303. Ertapenem.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21710 ; AAC21710 ; HI_0032 .
    GeneIDi 950929.
    KEGGi hin:HI0032.
    PATRICi 20188515. VBIHaeInf48452_0032.

    Phylogenomic databases

    eggNOGi COG0768.
    KOi K05515.
    OMAi NDGQVKT.
    OrthoDBi EOG6N0HHV.
    PhylomeDBi P44469.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03423. pbp2_mrdA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPBP2_HAEIN
    AccessioniPrimary (citable) accession number: P44469
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3