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P44466 (DACA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanyl-D-alanine carboxypeptidase dacA
Short name=DD-carboxypeptidase
Short name=DD-peptidase
EC=3.4.16.4
Alternative name(s):
Penicillin-binding protein 5
Short name=PBP-5
Gene names
Name:dacA
Ordered Locus Names:HI_0029
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors By similarity.

Catalytic activity

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity. Note: N-terminal lies in the periplasmic space By similarity.

Sequence similarities

Belongs to the peptidase S11 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 393375D-alanyl-D-alanine carboxypeptidase dacA
PRO_0000027232

Sites

Active site651Acyl-ester intermediate By similarity
Active site681Proton acceptor By similarity
Active site1281 By similarity
Binding site2311Substrate By similarity

Secondary structure

1 .......................................................... 393
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P44466 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 31DF0C563A833B7C

FASTA39343,414
        10         20         30         40         50         60 
MLKRTTKIAF LSSFVALSAF SVSAEDMQFG VTPPQITAQT YVLMDYNSGA ILTALNPDQR 

        70         80         90        100        110        120 
QYPASLTKMM TSYVVGVALK QGKIHNTDMV TIGESAWGRN FPDSSKMFLD LNTQVSVADL 

       130        140        150        160        170        180 
NRGVIVVSGN DATVALAEHI SGNVPNFVET MNKYVQQFGL KNTNFTTPHG LDDPNQYSSA 

       190        200        210        220        230        240 
RDMAIIGAHI IRDLPEEYKI YSEKNFTFNK IKQANRNGLL WDKTINVDGM KTGHTSQAGY 

       250        260        270        280        290        300 
NLVASATTSN NMRLISVVMG VPTYKGREVE SKKLLQWGFA NFETFKTLEA GKEISEQRVY 

       310        320        330        340        350        360 
YGDKNSVKLG ALMDHFITIP KGKQSEVKAR YELADKNLQA PLVKGQVIGK VVYQLDGKDI 

       370        380        390 
ASANLQVMND VGEAGIFGKL WDWLVLTVKG LFS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21707.1.
PIRI64043.
RefSeqNP_438202.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3A3JX-ray2.15A30-373[»]
ProteinModelPortalP44466.
SMRP44466. Positions 32-374.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950922.
GenomeReviewsGene locus HI_0029 in contig L42023_GR.
KEGGhin:HI0029.
NMPDRfig|71421.1.peg.28.
PATRIC20188509. VBIHaeInf48452_0029.
TIGRHI_0029.

Phylogenomic databases

HOGENOMHBG728991.
OMAEISEQRV.
ProtClustDBCLSK870669.

Enzyme and pathway databases

BioCycHINF71421:HI_0029-MONOMER.

Family and domain databases

InterProIPR012338. Beta-lactam/transpept-like.
IPR015956. Peniciliin-bd_prot-assoc.
IPR018044. Peptidase_S11.
IPR012907. Peptidase_S11_C.
IPR001967. Peptidase_S11_N.
[Graphical view]
Gene3DG3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.
G3DSA:2.60.410.10. Peptidase_S11_C. 1 hit.
KOK07258.
PfamPF07943. PBP5_C. 1 hit.
PF00768. Peptidase_S11. 1 hit.
[Graphical view]
PRINTSPR00725. DADACBPTASE1.
SMARTSM00936. PBP5_C. 1 hit.
[Graphical view]
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
SSF69189. Peniciliin-bd_prot-assoc. 1 hit.
ProtoNetSearch...

Other

DrugBankDB00303. Ertapenem.

Entry information

Entry nameDACA_HAEIN
AccessionPrimary (citable) accession number: P44466
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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