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P44462

- CITC_HAEIN

UniProt

P44462 - CITC_HAEIN

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Protein

[Citrate [pro-3S]-lyase] ligase

Gene
citC, HI_0025
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

Catalytic activityi

ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).

GO - Molecular functioni

  1. [citrate (pro-3S)-lyase] ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. N-acetyltransferase activity Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
[Citrate [pro-3S]-lyase] ligase (EC:6.2.1.22)
Alternative name(s):
Acetate:SH-citrate lyase ligase
Citrate lyase synthetase
Gene namesi
Name:citC
Ordered Locus Names:HI_0025
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335[Citrate [pro-3S]-lyase] ligasePRO_0000089771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0025.

Structurei

3D structure databases

ProteinModelPortaliP44462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 131131N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3053.
KOiK01910.
OMAiDCYTEID.
OrthoDBiEOG6WHNRS.
PhylomeDBiP44462.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR005216. Citrate_lyase_ligase.
IPR013166. Citrate_lyase_ligase_C.
IPR004821. Cyt_trans-like.
IPR000182. GNAT_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF08218. Citrate_ly_lig. 1 hit.
[Graphical view]
PIRSFiPIRSF005751. Acet_citr_lig. 1 hit.
SMARTiSM00764. Citrate_ly_lig. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00124. cit_ly_ligase. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44462-1 [UniParc]FASTAAdd to Basket

« Hide

MQFERISTEQ KKLSLIQTFL HQNALKLDEQ IEYFVVGYND NEQIVVCGGL    50
AGNIIKCVAI DESLRGSGVA LQLITELVDL AYTLKRPHLF IYTKPEYATL 100
FKSCGFYIIS DANPYVVLLE NSATRLQKQC SLWEKMRVDG NRIGSIVMNA 150
NPFTLGHRYL IEQALQQCDH LHLFIVGEDA SQFSYTERFE MIQQGIFDLS 200
NITLHSGSDY IISRATFPNY FLKDQLITDE SYFEIDLKLF RLHIAQALGI 250
THRFVGTELN CPVTAEYNRQ MHYWLMDAEM NAPKINVIEI PRKTASNHII 300
SASTVRKHLA EKNWAQLAEF VPMTTLNYLQ KCGRF 335
Length:335
Mass (Da):38,495
Last modified:November 1, 1995 - v1
Checksum:iBF7CE241C725C8EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21703.1.
PIRiF64043.
RefSeqiNP_438198.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21703; AAC21703; HI_0025.
GeneIDi950918.
KEGGihin:HI0025.
PATRICi20188501. VBIHaeInf48452_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21703.1 .
PIRi F64043.
RefSeqi NP_438198.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0025.

Protocols and materials databases

DNASUi 950918.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21703 ; AAC21703 ; HI_0025 .
GeneIDi 950918.
KEGGi hin:HI0025.
PATRICi 20188501. VBIHaeInf48452_0025.

Phylogenomic databases

eggNOGi COG3053.
KOi K01910.
OMAi DCYTEID.
OrthoDBi EOG6WHNRS.
PhylomeDBi P44462.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR005216. Citrate_lyase_ligase.
IPR013166. Citrate_lyase_ligase_C.
IPR004821. Cyt_trans-like.
IPR000182. GNAT_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF08218. Citrate_ly_lig. 1 hit.
[Graphical view ]
PIRSFi PIRSF005751. Acet_citr_lig. 1 hit.
SMARTi SM00764. Citrate_ly_lig. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00124. cit_ly_ligase. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCITC_HAEIN
AccessioniPrimary (citable) accession number: P44462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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