Reviewed, UniProtKB/Swiss-Prot P44462 (CITC_HAEIN)

Names and origin

Protein names

Recommended name:
    [Citrate [pro-3S]-lyase] ligase
    EC=6.2.1.22
Alternative name(s):
    Citrate lyase synthetase
    Acetate:SH-citrate lyase ligase

Gene names

Name:	citC
Ordered Locus Names:	HI0025

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
Catalytic activity	ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).
Sequence similarities	Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro [citrate (pro-3S)-lyase] ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	[Citrate [pro-3S]-lyase] ligase		PRO_0000089771
Regions
	Domain	1 – 131	131	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	P44462-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: BF7CE241C725C8EC	FASTA	335	38,495
	10 20 30 40 50 60 MQFERISTEQ KKLSLIQTFL HQNALKLDEQ IEYFVVGYND NEQIVVCGGL AGNIIKCVAI 70 80 90 100 110 120 DESLRGSGVA LQLITELVDL AYTLKRPHLF IYTKPEYATL FKSCGFYIIS DANPYVVLLE 130 140 150 160 170 180 NSATRLQKQC SLWEKMRVDG NRIGSIVMNA NPFTLGHRYL IEQALQQCDH LHLFIVGEDA 190 200 210 220 230 240 SQFSYTERFE MIQQGIFDLS NITLHSGSDY IISRATFPNY FLKDQLITDE SYFEIDLKLF 250 260 270 280 290 300 RLHIAQALGI THRFVGTELN CPVTAEYNRQ MHYWLMDAEM NAPKINVIEI PRKTASNHII 310 320 330 SASTVRKHLA EKNWAQLAEF VPMTTLNYLQ KCGRF

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21703.1.
PIR	F64043.
RefSeq	NP_438198.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950918.
GenomeReviews	Gene locus HI0025 in contig L42023_GR.
KEGG	hin:HI0025.
TIGR	HI0025.
Phylogenomic databases
HOGENOM	P44462.
OMA	MNCNPFT
Enzyme and pathway databases
BioCyc	HINF71421:HI_0025-MON.
BRENDA	6.2.1.22. 109.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR005216. Citrate_lyase_ligase. IPR013166. Citrate_lyase_ligase_C. IPR004821. Cyt_trans_rel. IPR000182. GCN5-rel_AcTrfase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF08218. Citrate_ly_lig. 1 hit. [Graphical view]
PIRSF	PIRSF005751. Acet_citr_lig. 1 hit.
SMART	SM00764. Citrate_ly_lig. 1 hit. [Graphical view]
TIGRFAMs	TIGR00124. cit_ly_ligase. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CITC_HAEIN

Accession

Primary (citable) accession number: P44462

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)