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Protein

[Citrate [pro-3S]-lyase] ligase

Gene

citC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

Catalytic activityi

ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
[Citrate [pro-3S]-lyase] ligase (EC:6.2.1.22)
Alternative name(s):
Acetate:SH-citrate lyase ligase
Citrate lyase synthetase
Gene namesi
Name:citC
Ordered Locus Names:HI_0025
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335[Citrate [pro-3S]-lyase] ligasePRO_0000089771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0025.

Structurei

3D structure databases

ProteinModelPortaliP44462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 131131N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3053.
KOiK01910.
OMAiFTRGHRY.
OrthoDBiEOG6WHNRS.
PhylomeDBiP44462.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR005216. Citrate_lyase_ligase.
IPR013166. Citrate_lyase_ligase_C.
IPR004821. Cyt_trans-like.
IPR000182. GNAT_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF08218. Citrate_ly_lig. 1 hit.
[Graphical view]
PIRSFiPIRSF005751. Acet_citr_lig. 1 hit.
SMARTiSM00764. Citrate_ly_lig. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00124. cit_ly_ligase. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFERISTEQ KKLSLIQTFL HQNALKLDEQ IEYFVVGYND NEQIVVCGGL
60 70 80 90 100
AGNIIKCVAI DESLRGSGVA LQLITELVDL AYTLKRPHLF IYTKPEYATL
110 120 130 140 150
FKSCGFYIIS DANPYVVLLE NSATRLQKQC SLWEKMRVDG NRIGSIVMNA
160 170 180 190 200
NPFTLGHRYL IEQALQQCDH LHLFIVGEDA SQFSYTERFE MIQQGIFDLS
210 220 230 240 250
NITLHSGSDY IISRATFPNY FLKDQLITDE SYFEIDLKLF RLHIAQALGI
260 270 280 290 300
THRFVGTELN CPVTAEYNRQ MHYWLMDAEM NAPKINVIEI PRKTASNHII
310 320 330
SASTVRKHLA EKNWAQLAEF VPMTTLNYLQ KCGRF
Length:335
Mass (Da):38,495
Last modified:November 1, 1995 - v1
Checksum:iBF7CE241C725C8EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21703.1.
PIRiF64043.
RefSeqiNP_438198.1. NC_000907.1.
WP_005668021.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21703; AAC21703; HI_0025.
GeneIDi950918.
KEGGihin:HI0025.
PATRICi20188501. VBIHaeInf48452_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21703.1.
PIRiF64043.
RefSeqiNP_438198.1. NC_000907.1.
WP_005668021.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0025.

Protocols and materials databases

DNASUi950918.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21703; AAC21703; HI_0025.
GeneIDi950918.
KEGGihin:HI0025.
PATRICi20188501. VBIHaeInf48452_0025.

Phylogenomic databases

eggNOGiCOG3053.
KOiK01910.
OMAiFTRGHRY.
OrthoDBiEOG6WHNRS.
PhylomeDBiP44462.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR005216. Citrate_lyase_ligase.
IPR013166. Citrate_lyase_ligase_C.
IPR004821. Cyt_trans-like.
IPR000182. GNAT_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF08218. Citrate_ly_lig. 1 hit.
[Graphical view]
PIRSFiPIRSF005751. Acet_citr_lig. 1 hit.
SMARTiSM00764. Citrate_ly_lig. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00124. cit_ly_ligase. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCITC_HAEIN
AccessioniPrimary (citable) accession number: P44462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.