P44462 (CITC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Citrate [pro-3S]-lyase] ligase
EC=6.2.1.22

Alternative name(s):
Acetate:SH-citrate lyase ligase
Citrate lyase synthetase

Gene names

Name:	citC
Ordered Locus Names:	HI_0025

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
Catalytic activity	ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).
Sequence similarities	Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro [citrate (pro-3S)-lyase] ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	[Citrate [pro-3S]-lyase] ligase		PRO_0000089771
Regions
	Domain	1 – 131	131	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	P44462 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: BF7CE241C725C8EC	FASTA	335	38,495
	10 20 30 40 50 60 MQFERISTEQ KKLSLIQTFL HQNALKLDEQ IEYFVVGYND NEQIVVCGGL AGNIIKCVAI 70 80 90 100 110 120 DESLRGSGVA LQLITELVDL AYTLKRPHLF IYTKPEYATL FKSCGFYIIS DANPYVVLLE 130 140 150 160 170 180 NSATRLQKQC SLWEKMRVDG NRIGSIVMNA NPFTLGHRYL IEQALQQCDH LHLFIVGEDA 190 200 210 220 230 240 SQFSYTERFE MIQQGIFDLS NITLHSGSDY IISRATFPNY FLKDQLITDE SYFEIDLKLF 250 260 270 280 290 300 RLHIAQALGI THRFVGTELN CPVTAEYNRQ MHYWLMDAEM NAPKINVIEI PRKTASNHII 310 320 330 SASTVRKHLA EKNWAQLAEF VPMTTLNYLQ KCGRF

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21703.1.
PIR	F64043.
RefSeq	NP_438198.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44462.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0025.
Protocols and materials databases
DNASU	950918.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC21703; AAC21703; HI_0025.
GeneID	950918.
KEGG	hin:HI0025.
PATRIC	20188501. VBIHaeInf48452_0025.
Phylogenomic databases
eggNOG	COG3053.
KO	K01910.
OMA	FTRGHRY.
ProtClustDB	CLSK874111.
Family and domain databases
Gene3D	3.40.50.620. 1 hit. 3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR005216. Citrate_lyase_ligase. IPR013166. Citrate_lyase_ligase_C. IPR004821. Cyt_trans-like. IPR000182. GNAT_dom. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Pfam	PF13508. Acetyltransf_7. 1 hit. PF08218. Citrate_ly_lig. 1 hit. [Graphical view]
PIRSF	PIRSF005751. Acet_citr_lig. 1 hit.
SMART	SM00764. Citrate_ly_lig. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR00124. cit_ly_ligase. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CITC_HAEIN

Accession

Primary (citable) accession number: P44462

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program