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P44462

- CITC_HAEIN

UniProt

P44462 - CITC_HAEIN

Protein

[Citrate [pro-3S]-lyase] ligase

Gene

citC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

    Catalytic activityi

    ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).

    GO - Molecular functioni

    1. [citrate (pro-3S)-lyase] ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. N-acetyltransferase activity Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [Citrate [pro-3S]-lyase] ligase (EC:6.2.1.22)
    Alternative name(s):
    Acetate:SH-citrate lyase ligase
    Citrate lyase synthetase
    Gene namesi
    Name:citC
    Ordered Locus Names:HI_0025
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335[Citrate [pro-3S]-lyase] ligasePRO_0000089771Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0025.

    Structurei

    3D structure databases

    ProteinModelPortaliP44462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 131131N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3053.
    KOiK01910.
    OMAiDCYTEID.
    OrthoDBiEOG6WHNRS.
    PhylomeDBiP44462.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR005216. Citrate_lyase_ligase.
    IPR013166. Citrate_lyase_ligase_C.
    IPR004821. Cyt_trans-like.
    IPR000182. GNAT_dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF08218. Citrate_ly_lig. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005751. Acet_citr_lig. 1 hit.
    SMARTiSM00764. Citrate_ly_lig. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR00124. cit_ly_ligase. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44462-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFERISTEQ KKLSLIQTFL HQNALKLDEQ IEYFVVGYND NEQIVVCGGL    50
    AGNIIKCVAI DESLRGSGVA LQLITELVDL AYTLKRPHLF IYTKPEYATL 100
    FKSCGFYIIS DANPYVVLLE NSATRLQKQC SLWEKMRVDG NRIGSIVMNA 150
    NPFTLGHRYL IEQALQQCDH LHLFIVGEDA SQFSYTERFE MIQQGIFDLS 200
    NITLHSGSDY IISRATFPNY FLKDQLITDE SYFEIDLKLF RLHIAQALGI 250
    THRFVGTELN CPVTAEYNRQ MHYWLMDAEM NAPKINVIEI PRKTASNHII 300
    SASTVRKHLA EKNWAQLAEF VPMTTLNYLQ KCGRF 335
    Length:335
    Mass (Da):38,495
    Last modified:November 1, 1995 - v1
    Checksum:iBF7CE241C725C8EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21703.1.
    PIRiF64043.
    RefSeqiNP_438198.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21703; AAC21703; HI_0025.
    GeneIDi950918.
    KEGGihin:HI0025.
    PATRICi20188501. VBIHaeInf48452_0025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21703.1 .
    PIRi F64043.
    RefSeqi NP_438198.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0025.

    Protocols and materials databases

    DNASUi 950918.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21703 ; AAC21703 ; HI_0025 .
    GeneIDi 950918.
    KEGGi hin:HI0025.
    PATRICi 20188501. VBIHaeInf48452_0025.

    Phylogenomic databases

    eggNOGi COG3053.
    KOi K01910.
    OMAi DCYTEID.
    OrthoDBi EOG6WHNRS.
    PhylomeDBi P44462.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR005216. Citrate_lyase_ligase.
    IPR013166. Citrate_lyase_ligase_C.
    IPR004821. Cyt_trans-like.
    IPR000182. GNAT_dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF08218. Citrate_ly_lig. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005751. Acet_citr_lig. 1 hit.
    SMARTi SM00764. Citrate_ly_lig. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR00124. cit_ly_ligase. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiCITC_HAEIN
    AccessioniPrimary (citable) accession number: P44462
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3