P44459 (CILA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Citrate lyase alpha chain
Short name=Citrase alpha chain
EC=4.1.3.6

Alternative name(s):
Citrate (pro-3S)-lyase alpha chain
Citrate CoA-transferase subunit
EC=2.8.3.10

Gene names

Name:	citF
Ordered Locus Names:	HI_0022

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Represents a citrate:acetyl-ACP transferase By similarity.
Catalytic activity	Citrate = acetate + oxaloacetate. Acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.
Subunit structure	Oligomer with a subunit composition of (alpha,beta, gamma)6 By similarity.
Subcellular location	Cytoplasm.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Lyase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	citrate lyase complex Inferred from electronic annotation. Source: InterPro
Molecular function	citrate (pro-3S)-lyase activity Inferred from electronic annotation. Source: EC citrate CoA-transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Citrate lyase alpha chain		PRO_0000089753

Sequences

	Sequence		Length	Mass (Da)
	P44459 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: F7D1EF303C446913	FASTA	500	54,134
	10 20 30 40 50 60 MTTREQRIEK YHADRSVYQA VPKSESLSRT AKDRKLCTSL EEAIKRSGLK DGMTVSFHHA 70 80 90 100 110 120 FRGGDFVVNM VMNKIAEMGF KNLTLASSSL IDSHFPIVEH IKNGVVTKIY SSGLRGELAE 130 140 150 160 170 180 QISRGLLNEP VNIHSHGGRV HLVKSGELKI DVAFLGVPCC DTFGNANGFT GKSKCGSLGY 190 200 210 220 230 240 ARVDAEYADK VVLLTEEFVE YPHHPISIAQ DQVDLIVQVE AVGDPKKIGG GATRMTTNPR 250 260 270 280 290 300 ELLIARKCAE VIFASGYFKD GFSLQTGSGG AALAVTRFLE EKMRRENITA DFALGGITAS 310 320 330 340 350 360 MVALHEAGLI KKLLDVQSFD SVAAESLARN PNHIEVSANQ YANYSSKGAS VERLDMVILS 370 380 390 400 410 420 ALEIDTKFNV NVLTGSDGVI RGASGGHCDT AASAQVAIIV APLVRGRIPT VVENVITCVT 430 440 450 460 470 480 PGENVDILVT DHGVAVNPKR PDLIEALSKT DIPLFTIEQL CERAYSITGK PKEIEFTNKP 490 500 VAVVRYRDGS VIDTVYQVKD

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21700.1.
PIR	C64043.
RefSeq	NP_438195.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44459.
SMR	P44459. Positions 32-499.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950920.
GenomeReviews	Gene locus HI_0022 in contig L42023_GR.
KEGG	hin:HI0022.
NMPDR	fig|71421.1.peg.21.
PATRIC	20188495. VBIHaeInf48452_0022.
TIGR	HI_0022.
Phylogenomic databases
HOGENOM	HBG297040.
OMA	KGSVINQ.
ProtClustDB	CLSK874113.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0022-MONOMER.
Family and domain databases
InterPro	IPR006472. Citrate_lyase_asu. [Graphical view]
KO	K01643.
Pfam	PF04223. CitF. 1 hit. [Graphical view]
PIRSF	PIRSF009451. Citrt_lyas_alpha. 1 hit.
TIGRFAMs	TIGR01584. CitF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CILA_HAEIN

Accession

Primary (citable) accession number: P44459

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program