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P44458

- CITXG_HAEIN

UniProt

P44458 - CITXG_HAEIN

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Protein

Protein CitXG

Gene
citXG, citG, HI_0021
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein By similarity.UniRule annotation

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.UniRule annotation
ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. holo-citrate lyase synthase activity Source: UniProtKB-EC
  3. triphosphoribosyl-dephospho-CoA synthase activity Source: InterPro

GO - Biological processi

  1. phosphorylation Source: InterPro
  2. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CitXG
Including the following 2 domains:
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
Gene namesi
Name:citXG
Synonyms:citG
Ordered Locus Names:HI_0021
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Protein CitXGUniRule annotationPRO_0000214682Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0021.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 182182Apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseUniRule annotationAdd
BLAST
Regioni183 – 4652832-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the CitX family.
In the C-terminal section; belongs to the CitG/MdcB family.

Phylogenomic databases

eggNOGiCOG1767.
KOiK13927.
OMAiLAQNHDF.
OrthoDBiEOG6WHNRS.

Family and domain databases

HAMAPiMF_00397. CitG.
MF_00398. CitX.
InterProiIPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

P44458-1 [UniParc]FASTAAdd to Basket

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MQHFFTTFST EGSKISLEAL LNAREERAIL QQQLITQYGQ TLLCITLTAM    50
GGVKKNALLD YVFTKALENL TALFTQLNIT AVKEIIRPLE TGHEAYFVLP 100
IDARTLKVLM IELEESIPLA RLWDLDVFNA KGNLLSRTDF DLSPRTCLVC 150
GENAKICART HKHEIDEIVD KIQSLAQNHD FAEHIGEQVY LALIQEARLS 200
PKPGLVDAIN NGSHKDMNLH TFEQSAISLK PFFTQFVLKG MMTAHLSENQ 250
ILSEIRPLGL LAEKAMFKVT DGVNTHKGAI FSFGLVCTAI GRLLAQKSLV 300
QSAVDFDVKL ICSLVAQFTQ GLTDELKNYP EHLPSTAGVR LFQKYGLTGV 350
RGEAENGFNL IQTLLPQFDE YHQLEWEHRL LILLLNLMAI NSDTNVVHRG 400
GLAGLYFIQQ TAQDLLTDQH LVTDKTALTQ ALMKFDTACI ERNLSSGGSA 450
DLLALTIFFL SFRGN 465
Length:465
Mass (Da):51,835
Last modified:June 1, 2001 - v2
Checksum:i4467221C3DB58A96
GO

Sequence cautioni

The sequence AAC21699.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21699.1. Different initiation.
PIRiE64140.
RefSeqiNP_438194.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21699; AAC21699; HI_0021.
GeneIDi950919.
KEGGihin:HI0021.
PATRICi20188493. VBIHaeInf48452_0021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21699.1 . Different initiation.
PIRi E64140.
RefSeqi NP_438194.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21699 ; AAC21699 ; HI_0021 .
GeneIDi 950919.
KEGGi hin:HI0021.
PATRICi 20188493. VBIHaeInf48452_0021.

Phylogenomic databases

eggNOGi COG1767.
KOi K13927.
OMAi LAQNHDF.
OrthoDBi EOG6WHNRS.

Family and domain databases

HAMAPi MF_00397. CitG.
MF_00398. CitX.
InterProi IPR002736. CitG.
IPR005551. CitX.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view ]
Pfami PF01874. CitG. 1 hit.
PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03125. citrate_citG. 1 hit.
TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiCITXG_HAEIN
AccessioniPrimary (citable) accession number: P44458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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