P44455 (GRCA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autonomous glycyl radical cofactor

Gene names

Name:	grcA
Ordered Locus Names:	HI_0017

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a radical domain for damaged PFL and possibly other radical proteins By similarity. HAMAP MF_00806
Sequence similarities	Contains 1 glycine radical domain.

Ontologies

Keywords
PTM	Organic radical
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Autonomous glycyl radical cofactor HAMAP MF_00806		PRO_0000166702
Regions
	Domain	5 – 127	123	Glycine radical
Amino acid modifications
	Modified residue	102	1	Glycine radical By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44455 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A3B896D3A479DB0A	FASTA	127	14,291
	10 20 30 40 50 60 MIKGIQITQA ANDNLLNSFW LLDSEKNEAR CLCAKGEFAE DQVVAVSELG QIEYRELPVN 70 80 90 100 110 120 VAPTVKVEGG QHLNVNVLRR ETLEDAVNNP DKYPQLTIRV SGYAVRFNSL TPEQQRDVIT RTFTESL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Reference map of the low molecular mass proteins of Haemophilus influenzae." Fountoulakis M., Juranville J.-F., Roeder D., Evers S., Berndt P., Langen H. Electrophoresis 19:1819-1827(1998) [PubMed: 9719565] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[3]	"Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed: 10675023] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21695.1.
PIR	C64140.
RefSeq	NP_438190.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44455.
SMR	P44455. Positions 67-127.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950913.
GenomeReviews	Gene locus HI_0017 in contig L42023_GR.
KEGG	hin:HI0017.
PATRIC	20188485. VBIHaeInf48452_0017.
TIGR	HI_0017.
Phylogenomic databases
HOGENOM	HBG297207.
OMA	GQFEYRE.
ProtClustDB	PRK11127.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0017-MONOMER.
Family and domain databases
HAMAP	MF_00806. GrcA. [Tree]
InterPro	IPR001150. Form_AcTrfase_GR. IPR019777. Form_AcTrfase_GR_CS. IPR011140. Glycyl_radical_cofactor_YfiD. [Graphical view]
KO	K06866.
Pfam	PF01228. Gly_radical. 1 hit. [Graphical view]
PIRSF	PIRSF000378. Gly_radicl_yfiD. 1 hit.
PROSITE	PS00850. GLY_RADICAL_1. 1 hit. PS51149. GLY_RADICAL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRCA_HAEIN

Accession

Primary (citable) accession number: P44455

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program