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P44454 (LEP_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal peptidase I

Short name=SPase I
EC=3.4.21.89
Alternative name(s):
Leader peptidase I
Gene names
Name:lepB
Ordered Locus Names:HI_0015
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S26 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
Protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type peptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Signal peptidase I
PRO_0000109507

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 8035Cytoplasmic Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 349248Periplasmic Potential

Sites

Active site1151 By similarity
Active site1961 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44454 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8BAF091DCDF92F60

FASTA34939,734
        10         20         30         40         50         60 
MSNLFFVILL AVGFGVWKVL DYFQLPNTFS ILLLILTALS GVLWCYHRFV VLPKRHRQVA 

        70         80         90        100        110        120 
RAEQRSGKTL SEEEKAKIEP ISEASEFLSS LFPVLAVVFL VRSFLFEPFQ IPSGSMESTL 

       130        140        150        160        170        180 
RVGDFLVVNK YAYGVKDPIF QNTIIAGEKP QRGDVIVFKA PQQALIRTGL GATRAAFAEN 

       190        200        210        220        230        240 
LALSSKDNMS GVDYIKRIVG KGGDRVIFDV EQKTLKVVYG KEGKPCEIDC ETKAFEYTQN 

       250        260        270        280        290        300 
PTNPAFPNEL ELTEKGDVTH NVLISEYRRY SDLEFFPQEG MQTAEWLVPE GQYFVMGDHR 

       310        320        330        340 
DHSDDSRFWG FVPEKNIVGK ATYIWMSLEK EANEWPTGFR FERFFTAIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21693.1.
PIRH64042.
RefSeqNP_438188.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44454.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0015.

Protein family/group databases

MEROPSS26.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21693; AAC21693; HI_0015.
GeneID950912.
KEGGhin:HI0015.
PATRIC20188481. VBIHaeInf48452_0015.

Phylogenomic databases

eggNOGCOG0681.
KOK03100.
OMASPWFVYF.
OrthoDBEOG6KDKTM.
ProtClustDBCLSK869948.

Family and domain databases

Gene3D2.10.109.10. 2 hits.
2.170.230.10. 1 hit.
InterProIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
IPR019766. Peptidase_S26A_all-beta_subdom.
[Graphical view]
PANTHERPTHR12383. PTHR12383. 1 hit.
PfamPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSPR00727. LEADERPTASE.
SUPFAMSSF51306. SSF51306. 2 hits.
TIGRFAMsTIGR02227. sigpep_I_bact. 1 hit.
PROSITEPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEP_HAEIN
AccessionPrimary (citable) accession number: P44454
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names