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P44454

- LEP_HAEIN

UniProt

P44454 - LEP_HAEIN

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Protein

Signal peptidase I

Gene

lepB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:HI_0015
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 8035CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 349248PeriplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Signal peptidase IPRO_0000109507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0015.

Structurei

3D structure databases

ProteinModelPortaliP44454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0681.
KOiK03100.
OMAiFKYPKDP.
OrthoDBiEOG6KDKTM.
PhylomeDBiP44454.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
2.170.230.10. 1 hit.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
IPR019766. Peptidase_S26A_all-beta_subdom.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 2 hits.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44454-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNLFFVILL AVGFGVWKVL DYFQLPNTFS ILLLILTALS GVLWCYHRFV
60 70 80 90 100
VLPKRHRQVA RAEQRSGKTL SEEEKAKIEP ISEASEFLSS LFPVLAVVFL
110 120 130 140 150
VRSFLFEPFQ IPSGSMESTL RVGDFLVVNK YAYGVKDPIF QNTIIAGEKP
160 170 180 190 200
QRGDVIVFKA PQQALIRTGL GATRAAFAEN LALSSKDNMS GVDYIKRIVG
210 220 230 240 250
KGGDRVIFDV EQKTLKVVYG KEGKPCEIDC ETKAFEYTQN PTNPAFPNEL
260 270 280 290 300
ELTEKGDVTH NVLISEYRRY SDLEFFPQEG MQTAEWLVPE GQYFVMGDHR
310 320 330 340
DHSDDSRFWG FVPEKNIVGK ATYIWMSLEK EANEWPTGFR FERFFTAIK
Length:349
Mass (Da):39,734
Last modified:November 1, 1995 - v1
Checksum:i8BAF091DCDF92F60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21693.1.
PIRiH64042.
RefSeqiNP_438188.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21693; AAC21693; HI_0015.
GeneIDi950912.
KEGGihin:HI0015.
PATRICi20188481. VBIHaeInf48452_0015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21693.1 .
PIRi H64042.
RefSeqi NP_438188.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44454.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0015.

Protein family/group databases

MEROPSi S26.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21693 ; AAC21693 ; HI_0015 .
GeneIDi 950912.
KEGGi hin:HI0015.
PATRICi 20188481. VBIHaeInf48452_0015.

Phylogenomic databases

eggNOGi COG0681.
KOi K03100.
OMAi FKYPKDP.
OrthoDBi EOG6KDKTM.
PhylomeDBi P44454.

Family and domain databases

Gene3Di 2.10.109.10. 2 hits.
2.170.230.10. 1 hit.
InterProi IPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
IPR019766. Peptidase_S26A_all-beta_subdom.
[Graphical view ]
PANTHERi PTHR12383. PTHR12383. 1 hit.
Pfami PF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view ]
PRINTSi PR00727. LEADERPTASE.
SUPFAMi SSF51306. SSF51306. 2 hits.
TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
PROSITEi PS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiLEP_HAEIN
AccessioniPrimary (citable) accession number: P44454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3