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P44454

- LEP_HAEIN

UniProt

P44454 - LEP_HAEIN

Protein

Signal peptidase I

Gene

lepB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151By similarity
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease

    Protein family/group databases

    MEROPSiS26.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase I (EC:3.4.21.89)
    Short name:
    SPase I
    Alternative name(s):
    Leader peptidase I
    Gene namesi
    Name:lepB
    Ordered Locus Names:HI_0015
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Signal peptidase IPRO_0000109507Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0015.

    Structurei

    3D structure databases

    ProteinModelPortaliP44454.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini46 – 8035CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 349248PeriplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    KOiK03100.
    OMAiFKYPKDP.
    OrthoDBiEOG6KDKTM.
    PhylomeDBiP44454.

    Family and domain databases

    Gene3Di2.10.109.10. 2 hits.
    2.170.230.10. 1 hit.
    InterProiIPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR019533. Peptidase_S26.
    IPR019766. Peptidase_S26A_all-beta_subdom.
    [Graphical view]
    PANTHERiPTHR12383. PTHR12383. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    PF10502. Peptidase_S26. 1 hit.
    [Graphical view]
    PRINTSiPR00727. LEADERPTASE.
    SUPFAMiSSF51306. SSF51306. 2 hits.
    TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
    PROSITEiPS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44454-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNLFFVILL AVGFGVWKVL DYFQLPNTFS ILLLILTALS GVLWCYHRFV    50
    VLPKRHRQVA RAEQRSGKTL SEEEKAKIEP ISEASEFLSS LFPVLAVVFL 100
    VRSFLFEPFQ IPSGSMESTL RVGDFLVVNK YAYGVKDPIF QNTIIAGEKP 150
    QRGDVIVFKA PQQALIRTGL GATRAAFAEN LALSSKDNMS GVDYIKRIVG 200
    KGGDRVIFDV EQKTLKVVYG KEGKPCEIDC ETKAFEYTQN PTNPAFPNEL 250
    ELTEKGDVTH NVLISEYRRY SDLEFFPQEG MQTAEWLVPE GQYFVMGDHR 300
    DHSDDSRFWG FVPEKNIVGK ATYIWMSLEK EANEWPTGFR FERFFTAIK 349
    Length:349
    Mass (Da):39,734
    Last modified:November 1, 1995 - v1
    Checksum:i8BAF091DCDF92F60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21693.1.
    PIRiH64042.
    RefSeqiNP_438188.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21693; AAC21693; HI_0015.
    GeneIDi950912.
    KEGGihin:HI0015.
    PATRICi20188481. VBIHaeInf48452_0015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21693.1 .
    PIRi H64042.
    RefSeqi NP_438188.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44454.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0015.

    Protein family/group databases

    MEROPSi S26.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21693 ; AAC21693 ; HI_0015 .
    GeneIDi 950912.
    KEGGi hin:HI0015.
    PATRICi 20188481. VBIHaeInf48452_0015.

    Phylogenomic databases

    eggNOGi COG0681.
    KOi K03100.
    OMAi FKYPKDP.
    OrthoDBi EOG6KDKTM.
    PhylomeDBi P44454.

    Family and domain databases

    Gene3Di 2.10.109.10. 2 hits.
    2.170.230.10. 1 hit.
    InterProi IPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR019533. Peptidase_S26.
    IPR019766. Peptidase_S26A_all-beta_subdom.
    [Graphical view ]
    PANTHERi PTHR12383. PTHR12383. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    PF10502. Peptidase_S26. 1 hit.
    [Graphical view ]
    PRINTSi PR00727. LEADERPTASE.
    SUPFAMi SSF51306. SSF51306. 2 hits.
    TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
    PROSITEi PS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiLEP_HAEIN
    AccessioniPrimary (citable) accession number: P44454
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3