P44453 (RSMC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase C
EC=2.1.1.172

Alternative name(s):
16S rRNA m2G1207 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RsmC

Gene names

Name:	rsmC
Ordered Locus Names:	HI_0012

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle By similarity. HAMAP MF_01862
Catalytic activity	S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1207) in 16S rRNA. HAMAP MF_01862
Subunit structure	Monomer By similarity. HAMAP MF_01862
Subcellular location	Cytoplasm Potential HAMAP MF_01862.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Ribosomal RNA small subunit methyltransferase C HAMAP MF_01862		PRO_0000097491

Sequences

	Sequence		Length	Mass (Da)
	P44453 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7FF723E3993D9B69	FASTA	330	37,061
	10 20 30 40 50 60 MISLESQVLE RHISFFDGKS VLFAGGISDS FPQTLASKCS SIQIWSCYFD YARTQSAVNF 70 80 90 100 110 120 SVEFQGQADL IVYYWTKNKQ EVNFQLIQLL AQASIGQEIL IIGENRCGVR SVEKTLSPYG 130 140 150 160 170 180 EIAKIDSARR CGLYHFSLQN KPHFELKNFW RTYQHSTLEN LTIYSLPGVF SAAELDTGTE 190 200 210 220 230 240 LLLSTIDNKI KGKVLDLGCG AGVIGSMIKK RTPNAQITMT DIHAMALESA RKTLSENQLQ 250 260 270 280 290 300 GEVYASDVFS DIEGKFDLII SNPPFHDGID TAYRAVTELI TQAKWHLNQG GELRIVANSF 310 320 330 LPYPELLRQH FNDYQVLAQT GKFKVYSVKN

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21690.1.
PIR	B64140.
RefSeq	NP_438185.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44453.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950903.
GenomeReviews	Gene locus HI_0012 in contig L42023_GR.
KEGG	hin:HI0012.
NMPDR	fig|71421.1.peg.11.
PATRIC	20188475. VBIHaeInf48452_0012.
TIGR	HI_0012.
Phylogenomic databases
HOGENOM	HBG296757.
OMA	TGKFKVY.
ProtClustDB	PRK09489.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0012-MONOMER.
Family and domain databases
HAMAP	MF_01862. 16SrRNA_methyltr_C. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR023543. rRNA_ssu_MeTfrase_C. IPR007848. Small_mtfrase. [Graphical view]
KO	K00564.
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_HAEIN

Accession

Primary (citable) accession number: P44453

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program