Reviewed, UniProtKB/Swiss-Prot P44453 (RSMC_HAEIN)

Names and origin

Protein names

Recommended name:
    Ribosomal RNA small subunit methyltransferase C
    EC=2.1.1.52
Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase rsmC
    16S rRNA m2G1207 methyltransferase

Gene names

Name:	rsmC
Ordered Locus Names:	HI0012

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle By similarity.
Catalytic activity	S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(2)-methylguanine. HAMAP MF_01862
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA methylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Ribosomal RNA small subunit methyltransferase C HAMAP MF_01862		PRO_0000097491

Sequences

	Sequence		Length	Mass (Da)
	P44453-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7FF723E3993D9B69	FASTA	330	37,061
	10 20 30 40 50 60 MISLESQVLE RHISFFDGKS VLFAGGISDS FPQTLASKCS SIQIWSCYFD YARTQSAVNF 70 80 90 100 110 120 SVEFQGQADL IVYYWTKNKQ EVNFQLIQLL AQASIGQEIL IIGENRCGVR SVEKTLSPYG 130 140 150 160 170 180 EIAKIDSARR CGLYHFSLQN KPHFELKNFW RTYQHSTLEN LTIYSLPGVF SAAELDTGTE 190 200 210 220 230 240 LLLSTIDNKI KGKVLDLGCG AGVIGSMIKK RTPNAQITMT DIHAMALESA RKTLSENQLQ 250 260 270 280 290 300 GEVYASDVFS DIEGKFDLII SNPPFHDGID TAYRAVTELI TQAKWHLNQG GELRIVANSF 310 320 330 LPYPELLRQH FNDYQVLAQT GKFKVYSVKN

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21690.1.
PIR	B64140.
RefSeq	NP_438185.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950903.
GenomeReviews	Gene locus HI0012 in contig L42023_GR.
KEGG	hin:HI0012.
NMPDR	fig|71421.1.peg.11.
TIGR	HI0012.
Phylogenomic databases
HOGENOM	P44453.
OMA	TGKFKVY
Enzyme and pathway databases
BioCyc	HINF71421:HI_0012-MON.
BRENDA	2.1.1.52. 109.
Family and domain databases
HAMAP	MF_01862. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR007848. Small_mtfrase. [Graphical view]
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_HAEIN

Accession

Primary (citable) accession number: P44453

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)