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Protein

Ribosomal RNA small subunit methyltransferase C

Gene

rsmC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1207) in 16S rRNA.UniRule annotation

GO - Molecular functioni

  1. 16S rRNA (guanine(1207)-N(2))-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase CUniRule annotation (EC:2.1.1.172UniRule annotation)
Alternative name(s):
16S rRNA m2G1207 methyltransferaseUniRule annotation
rRNA (guanine-N(2)-)-methyltransferase RsmCUniRule annotation
Gene namesi
Name:rsmCUniRule annotation
Ordered Locus Names:HI_0012
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Ribosomal RNA small subunit methyltransferase CPRO_0000097491Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0012.

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2813.
KOiK00564.
OMAiRHCQLWQ.
OrthoDBiEOG67X1ZC.
PhylomeDBiP44453.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01862. 16SrRNA_methyltr_C.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR013675. Mtase_sm_N.
IPR023543. rRNA_ssu_MeTfrase_C.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
PF08468. MTS_N. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

P44453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLESQVLE RHISFFDGKS VLFAGGISDS FPQTLASKCS SIQIWSCYFD
60 70 80 90 100
YARTQSAVNF SVEFQGQADL IVYYWTKNKQ EVNFQLIQLL AQASIGQEIL
110 120 130 140 150
IIGENRCGVR SVEKTLSPYG EIAKIDSARR CGLYHFSLQN KPHFELKNFW
160 170 180 190 200
RTYQHSTLEN LTIYSLPGVF SAAELDTGTE LLLSTIDNKI KGKVLDLGCG
210 220 230 240 250
AGVIGSMIKK RTPNAQITMT DIHAMALESA RKTLSENQLQ GEVYASDVFS
260 270 280 290 300
DIEGKFDLII SNPPFHDGID TAYRAVTELI TQAKWHLNQG GELRIVANSF
310 320 330
LPYPELLRQH FNDYQVLAQT GKFKVYSVKN
Length:330
Mass (Da):37,061
Last modified:November 1, 1995 - v1
Checksum:i7FF723E3993D9B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21690.1.
PIRiB64140.
RefSeqiNP_438185.1. NC_000907.1.
WP_005693888.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21690; AAC21690; HI_0012.
GeneIDi950903.
KEGGihin:HI0012.
PATRICi20188475. VBIHaeInf48452_0012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21690.1.
PIRiB64140.
RefSeqiNP_438185.1. NC_000907.1.
WP_005693888.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21690; AAC21690; HI_0012.
GeneIDi950903.
KEGGihin:HI0012.
PATRICi20188475. VBIHaeInf48452_0012.

Phylogenomic databases

eggNOGiCOG2813.
KOiK00564.
OMAiRHCQLWQ.
OrthoDBiEOG67X1ZC.
PhylomeDBiP44453.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01862. 16SrRNA_methyltr_C.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR013675. Mtase_sm_N.
IPR023543. rRNA_ssu_MeTfrase_C.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
PF08468. MTS_N. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRSMC_HAEIN
AccessioniPrimary (citable) accession number: P44453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.