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P44450 (FDXH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Formate dehydrogenase iron-sulfur subunit
Alternative name(s):
Formate dehydrogenase subunit beta
Short name=FDH subunit beta
Gene names
Name:fdxH
Ordered Locus Names:HI_0007
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit By similarity.

Subunit structure

Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

Subcellular location

Cell membrane By similarity.

Sequence similarities

Contains 4 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Formate dehydrogenase iron-sulfur subunit
PRO_0000159252

Regions

Domain35 – 65314Fe-4S ferredoxin-type 1
Domain97 – 129334Fe-4S ferredoxin-type 2
Domain130 – 159304Fe-4S ferredoxin-type 3
Domain164 – 195324Fe-4S ferredoxin-type 4

Sites

Metal binding441Iron-sulfur 1 (4Fe-4S) By similarity
Metal binding471Iron-sulfur 1 (4Fe-4S) By similarity
Metal binding501Iron-sulfur 1 (4Fe-4S) By similarity
Metal binding541Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1061Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1141Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1181Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1391Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1421Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1451Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1661Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1691Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1811Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1851Iron-sulfur 1 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P44450 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: AA49DD3C17064866

FASTA31234,069
        10         20         30         40         50         60 
MAGTAQGVQT QDVIKISATS GLTPAPQARD HKVEIAKLID VSTCIGCKAC QVGCSEWNDI 

        70         80         90        100        110        120 
RSDINAQCVG VYDNPVDLDA KAWTVMRFNE VEENDRLEWL IRKDGCMHCT EPGCLKACPA 

       130        140        150        160        170        180 
PGAIIQYANG IVDFQSDKCI GCGYCIAGCP FNIPRMNPED NRVYKCTLCV DRVSVGQEPA 

       190        200        210        220        230        240 
CVKTCPTGAI RFGSKEEMKI YAEQRVADLK SRGYENAGLY DPPGVGGTHV MYVLHHADKP 

       250        260        270        280        290        300 
ELYNGLPKDP QIDLSVTLWK DVLKPVAAVA MGGLALAEVA HYLTVGPNVE EDVEDHHHEF 

       310 
EENKPSKGEN NE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21685.1.
PIRA64042.
RefSeqNP_438180.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44450.
SMRP44450. Positions 7-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21685; AAC21685; HI_0007.
GeneID950904.
KEGGhin:HI0007.
PATRIC20188465. VBIHaeInf48452_0007.

Phylogenomic databases

eggNOGCOG0437.
KOK00124.
OMASVTLWKD.
OrthoDBEOG6XSZQF.
PhylomeDBP44450.

Family and domain databases

InterProIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR006470. Formate_DH_bsu.
IPR014603. Formate_DH_Fe-S_su.
IPR015246. Formate_DH_TM.
[Graphical view]
PfamPF13247. Fer4_11. 1 hit.
PF12800. Fer4_4. 1 hit.
PF09163. Form-deh_trans. 1 hit.
[Graphical view]
PIRSFPIRSF036298. FDH_4Fe4S. 1 hit.
TIGRFAMsTIGR01582. FDH-beta. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDXH_HAEIN
AccessionPrimary (citable) accession number: P44450
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names