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P44450

- FDXH_HAEIN

UniProt

P44450 - FDXH_HAEIN

Protein

Formate dehydrogenase iron-sulfur subunit

Gene

fdxH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit By similarity.By similarity

    Cofactori

    Binds 4 4Fe-4S clusters per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi47 – 471Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi50 – 501Iron-sulfur 1 (4Fe-4S)By similarity
    Metal bindingi54 – 541Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi106 – 1061Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi109 – 1091Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi114 – 1141Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi118 – 1181Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi139 – 1391Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi142 – 1421Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi145 – 1451Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi149 – 1491Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi166 – 1661Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi181 – 1811Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi185 – 1851Iron-sulfur 1 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. formate dehydrogenase (NAD+) activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular respiration Source: InterPro

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase iron-sulfur subunit
    Alternative name(s):
    Formate dehydrogenase subunit beta
    Short name:
    FDH subunit beta
    Gene namesi
    Name:fdxH
    Ordered Locus Names:HI_0007
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cell membrane By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Formate dehydrogenase iron-sulfur subunitPRO_0000159252Add
    BLAST

    Interactioni

    Subunit structurei

    Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

    Protein-protein interaction databases

    STRINGi71421.HI0007.

    Structurei

    3D structure databases

    ProteinModelPortaliP44450.
    SMRiP44450. Positions 7-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 65314Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini97 – 129334Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 159304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 195324Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane

    Phylogenomic databases

    eggNOGiCOG0437.
    KOiK00124.
    OMAiSVTLWKD.
    OrthoDBiEOG6XSZQF.
    PhylomeDBiP44450.

    Family and domain databases

    InterProiIPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR006470. Formate_DH_bsu.
    IPR014603. Formate_DH_Fe-S_su.
    IPR015246. Formate_DH_TM.
    [Graphical view]
    PfamiPF13247. Fer4_11. 1 hit.
    PF12800. Fer4_4. 1 hit.
    PF09163. Form-deh_trans. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036298. FDH_4Fe4S. 1 hit.
    TIGRFAMsiTIGR01582. FDH-beta. 1 hit.
    PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44450-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGTAQGVQT QDVIKISATS GLTPAPQARD HKVEIAKLID VSTCIGCKAC    50
    QVGCSEWNDI RSDINAQCVG VYDNPVDLDA KAWTVMRFNE VEENDRLEWL 100
    IRKDGCMHCT EPGCLKACPA PGAIIQYANG IVDFQSDKCI GCGYCIAGCP 150
    FNIPRMNPED NRVYKCTLCV DRVSVGQEPA CVKTCPTGAI RFGSKEEMKI 200
    YAEQRVADLK SRGYENAGLY DPPGVGGTHV MYVLHHADKP ELYNGLPKDP 250
    QIDLSVTLWK DVLKPVAAVA MGGLALAEVA HYLTVGPNVE EDVEDHHHEF 300
    EENKPSKGEN NE 312
    Length:312
    Mass (Da):34,069
    Last modified:November 1, 1995 - v1
    Checksum:iAA49DD3C17064866
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21685.1.
    PIRiA64042.
    RefSeqiNP_438180.1. NC_000907.1.
    WP_005693893.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21685; AAC21685; HI_0007.
    GeneIDi950904.
    KEGGihin:HI0007.
    PATRICi20188465. VBIHaeInf48452_0007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21685.1 .
    PIRi A64042.
    RefSeqi NP_438180.1. NC_000907.1.
    WP_005693893.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44450.
    SMRi P44450. Positions 7-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21685 ; AAC21685 ; HI_0007 .
    GeneIDi 950904.
    KEGGi hin:HI0007.
    PATRICi 20188465. VBIHaeInf48452_0007.

    Phylogenomic databases

    eggNOGi COG0437.
    KOi K00124.
    OMAi SVTLWKD.
    OrthoDBi EOG6XSZQF.
    PhylomeDBi P44450.

    Family and domain databases

    InterProi IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR006470. Formate_DH_bsu.
    IPR014603. Formate_DH_Fe-S_su.
    IPR015246. Formate_DH_TM.
    [Graphical view ]
    Pfami PF13247. Fer4_11. 1 hit.
    PF12800. Fer4_4. 1 hit.
    PF09163. Form-deh_trans. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036298. FDH_4Fe4S. 1 hit.
    TIGRFAMsi TIGR01582. FDH-beta. 1 hit.
    PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFDXH_HAEIN
    AccessioniPrimary (citable) accession number: P44450
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3