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Protein

Formate dehydrogenase iron-sulfur subunit

Gene

fdxH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi47Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi50Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi54Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi106Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi109Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi114Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi118Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi139Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi142Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi145Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi149Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi166Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi169Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi181Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi185Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase iron-sulfur subunit
Alternative name(s):
Formate dehydrogenase subunit beta
Short name:
FDH subunit beta
Gene namesi
Name:fdxH
Ordered Locus Names:HI_0007
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592521 – 312Formate dehydrogenase iron-sulfur subunitAdd BLAST312

Interactioni

Subunit structurei

Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

Protein-protein interaction databases

STRINGi71421.HI0007.

Structurei

3D structure databases

ProteinModelPortaliP44450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini97 – 1294Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST33
Domaini130 – 1594Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini164 – 1954Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Contains 4 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane

Phylogenomic databases

eggNOGiENOG4105QA4. Bacteria.
COG0437. LUCA.
KOiK00124.
OMAiQQDNCIG.
PhylomeDBiP44450.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR006470. Formate_DH_bsu_Proteobacteria.
IPR014603. Formate_DH_Fe-S_su.
IPR015246. Formate_DH_TM.
[Graphical view]
PfamiPF13247. Fer4_11. 1 hit.
PF09163. Form-deh_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF036298. FDH_4Fe4S. 1 hit.
TIGRFAMsiTIGR01582. FDH-beta. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTAQGVQT QDVIKISATS GLTPAPQARD HKVEIAKLID VSTCIGCKAC
60 70 80 90 100
QVGCSEWNDI RSDINAQCVG VYDNPVDLDA KAWTVMRFNE VEENDRLEWL
110 120 130 140 150
IRKDGCMHCT EPGCLKACPA PGAIIQYANG IVDFQSDKCI GCGYCIAGCP
160 170 180 190 200
FNIPRMNPED NRVYKCTLCV DRVSVGQEPA CVKTCPTGAI RFGSKEEMKI
210 220 230 240 250
YAEQRVADLK SRGYENAGLY DPPGVGGTHV MYVLHHADKP ELYNGLPKDP
260 270 280 290 300
QIDLSVTLWK DVLKPVAAVA MGGLALAEVA HYLTVGPNVE EDVEDHHHEF
310
EENKPSKGEN NE
Length:312
Mass (Da):34,069
Last modified:November 1, 1995 - v1
Checksum:iAA49DD3C17064866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21685.1.
PIRiA64042.
RefSeqiNP_438180.1. NC_000907.1.
WP_005693893.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21685; AAC21685; HI_0007.
GeneIDi950904.
KEGGihin:HI0007.
PATRICi20188465. VBIHaeInf48452_0007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21685.1.
PIRiA64042.
RefSeqiNP_438180.1. NC_000907.1.
WP_005693893.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21685; AAC21685; HI_0007.
GeneIDi950904.
KEGGihin:HI0007.
PATRICi20188465. VBIHaeInf48452_0007.

Phylogenomic databases

eggNOGiENOG4105QA4. Bacteria.
COG0437. LUCA.
KOiK00124.
OMAiQQDNCIG.
PhylomeDBiP44450.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR006470. Formate_DH_bsu_Proteobacteria.
IPR014603. Formate_DH_Fe-S_su.
IPR015246. Formate_DH_TM.
[Graphical view]
PfamiPF13247. Fer4_11. 1 hit.
PF09163. Form-deh_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF036298. FDH_4Fe4S. 1 hit.
TIGRFAMsiTIGR01582. FDH-beta. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDXH_HAEIN
AccessioniPrimary (citable) accession number: P44450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.