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P44450

- FDXH_HAEIN

UniProt

P44450 - FDXH_HAEIN

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Protein

Formate dehydrogenase iron-sulfur subunit

Gene

fdxH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi47 – 471Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi50 – 501Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi54 – 541Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi106 – 1061Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi109 – 1091Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi114 – 1141Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi118 – 1181Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi139 – 1391Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi142 – 1421Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi145 – 1451Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi149 – 1491Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi166 – 1661Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi181 – 1811Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi185 – 1851Iron-sulfur 1 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. formate dehydrogenase (NAD+) activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular respiration Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase iron-sulfur subunit
Alternative name(s):
Formate dehydrogenase subunit beta
Short name:
FDH subunit beta
Gene namesi
Name:fdxH
Ordered Locus Names:HI_0007
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cell membrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Formate dehydrogenase iron-sulfur subunitPRO_0000159252Add
BLAST

Interactioni

Subunit structurei

Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

Protein-protein interaction databases

STRINGi71421.HI0007.

Structurei

3D structure databases

ProteinModelPortaliP44450.
SMRiP44450. Positions 7-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 65314Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini97 – 129334Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 159304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini164 – 195324Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane

Phylogenomic databases

eggNOGiCOG0437.
KOiK00124.
OMAiSVTLWKD.
OrthoDBiEOG6XSZQF.
PhylomeDBiP44450.

Family and domain databases

InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR006470. Formate_DH_bsu.
IPR014603. Formate_DH_Fe-S_su.
IPR015246. Formate_DH_TM.
[Graphical view]
PfamiPF13247. Fer4_11. 1 hit.
PF12800. Fer4_4. 1 hit.
PF09163. Form-deh_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF036298. FDH_4Fe4S. 1 hit.
TIGRFAMsiTIGR01582. FDH-beta. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGTAQGVQT QDVIKISATS GLTPAPQARD HKVEIAKLID VSTCIGCKAC
60 70 80 90 100
QVGCSEWNDI RSDINAQCVG VYDNPVDLDA KAWTVMRFNE VEENDRLEWL
110 120 130 140 150
IRKDGCMHCT EPGCLKACPA PGAIIQYANG IVDFQSDKCI GCGYCIAGCP
160 170 180 190 200
FNIPRMNPED NRVYKCTLCV DRVSVGQEPA CVKTCPTGAI RFGSKEEMKI
210 220 230 240 250
YAEQRVADLK SRGYENAGLY DPPGVGGTHV MYVLHHADKP ELYNGLPKDP
260 270 280 290 300
QIDLSVTLWK DVLKPVAAVA MGGLALAEVA HYLTVGPNVE EDVEDHHHEF
310
EENKPSKGEN NE
Length:312
Mass (Da):34,069
Last modified:November 1, 1995 - v1
Checksum:iAA49DD3C17064866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21685.1.
PIRiA64042.
RefSeqiNP_438180.1. NC_000907.1.
WP_005693893.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21685; AAC21685; HI_0007.
GeneIDi950904.
KEGGihin:HI0007.
PATRICi20188465. VBIHaeInf48452_0007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21685.1 .
PIRi A64042.
RefSeqi NP_438180.1. NC_000907.1.
WP_005693893.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44450.
SMRi P44450. Positions 7-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21685 ; AAC21685 ; HI_0007 .
GeneIDi 950904.
KEGGi hin:HI0007.
PATRICi 20188465. VBIHaeInf48452_0007.

Phylogenomic databases

eggNOGi COG0437.
KOi K00124.
OMAi SVTLWKD.
OrthoDBi EOG6XSZQF.
PhylomeDBi P44450.

Family and domain databases

InterProi IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR006470. Formate_DH_bsu.
IPR014603. Formate_DH_Fe-S_su.
IPR015246. Formate_DH_TM.
[Graphical view ]
Pfami PF13247. Fer4_11. 1 hit.
PF12800. Fer4_4. 1 hit.
PF09163. Form-deh_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF036298. FDH_4Fe4S. 1 hit.
TIGRFAMsi TIGR01582. FDH-beta. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFDXH_HAEIN
AccessioniPrimary (citable) accession number: P44450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3