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P44446

- LCFH_HAEIN

UniProt

P44446 - LCFH_HAEIN

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Protein

Putative long-chain-fatty-acid--CoA ligase

Gene

HI_0002

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Short name:
LACS
Gene namesi
Ordered Locus Names:HI_0002
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Putative long-chain-fatty-acid--CoA ligasePRO_0000193123Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0002.

Structurei

3D structure databases

ProteinModelPortaliP44446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
KOiK01897.
OMAiFYEKIYA.
OrthoDBiEOG64FKGZ.
PhylomeDBiP44446.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44446-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE
60 70 80 90 100
QLNQLSRALL AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT
110 120 130 140 150
NTAQQAEFIL NHADVKILFV GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ
160 170 180 190 200
LQQDPLSCTW ESFIKTGSNA QQDELTQRLN QKQLSDLFTI IYTSGTTGEP
210 220 230 240 250
KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE RAWAAYILHR
260 270 280 290 300
GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR
310 320 330 340 350
QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR
360 370 380 390 400
IKMMPCGGAK LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN
410 420 430 440 450
SIGTLMPKAE VKIGENNEIL VRGGMVMKGY YKKPEETAQA FTEDGFLKTG
460 470 480 490 500
DAGEFDEQGN LFITDRIKEL MKTSNGKYIA PQYIESKIGK DKFIEQIAII
510 520 530 540 550
ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD ILKMFEHRIN
560 570 580 590 600
AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA

MYHSQEA
Length:607
Mass (Da):69,694
Last modified:November 1, 1995 - v1
Checksum:i111A5AA7A545D674
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21681.1.
PIRiH64041.
RefSeqiNP_438175.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21681; AAC21681; HI_0002.
GeneIDi950897.
KEGGihin:HI0002.
PATRICi20188455. VBIHaeInf48452_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21681.1 .
PIRi H64041.
RefSeqi NP_438175.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21681 ; AAC21681 ; HI_0002 .
GeneIDi 950897.
KEGGi hin:HI0002.
PATRICi 20188455. VBIHaeInf48452_0002.

Phylogenomic databases

eggNOGi COG1022.
KOi K01897.
OMAi FYEKIYA.
OrthoDBi EOG64FKGZ.
PhylomeDBi P44446.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiLCFH_HAEIN
AccessioniPrimary (citable) accession number: P44446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3