Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P44446 (LCFH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative long-chain-fatty-acid--CoA ligase

EC=6.2.1.3
Alternative name(s):
Long-chain acyl-CoA synthetase
Short name=LACS
Gene names
Ordered Locus Names:HI_0002
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 607607Putative long-chain-fatty-acid--CoA ligase
PRO_0000193123

Sequences

Sequence LengthMass (Da)Tools
P44446 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 111A5AA7A545D674

FASTA60769,694
        10         20         30         40         50         60 
MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE QLNQLSRALL 

        70         80         90        100        110        120 
AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT NTAQQAEFIL NHADVKILFV 

       130        140        150        160        170        180 
GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ LQQDPLSCTW ESFIKTGSNA QQDELTQRLN 

       190        200        210        220        230        240 
QKQLSDLFTI IYTSGTTGEP KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE 

       250        260        270        280        290        300 
RAWAAYILHR GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR 

       310        320        330        340        350        360 
QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR IKMMPCGGAK 

       370        380        390        400        410        420 
LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN SIGTLMPKAE VKIGENNEIL 

       430        440        450        460        470        480 
VRGGMVMKGY YKKPEETAQA FTEDGFLKTG DAGEFDEQGN LFITDRIKEL MKTSNGKYIA 

       490        500        510        520        530        540 
PQYIESKIGK DKFIEQIAII ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD 

       550        560        570        580        590        600 
ILKMFEHRIN AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA 


MYHSQEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21681.1.
PIRH64041.
RefSeqNP_438175.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0002.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21681; AAC21681; HI_0002.
GeneID950897.
KEGGhin:HI0002.
PATRIC20188455. VBIHaeInf48452_0002.

Phylogenomic databases

eggNOGCOG1022.
KOK01897.
OMAFYEKIYA.
OrthoDBEOG64FKGZ.
PhylomeDBP44446.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCFH_HAEIN
AccessionPrimary (citable) accession number: P44446
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names