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Protein

Putative long-chain-fatty-acid--CoA ligase

Gene

HI_0002

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-2-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Short name:
LACS
Gene namesi
Ordered Locus Names:HI_0002
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931231 – 607Putative long-chain-fatty-acid--CoA ligaseAdd BLAST607

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0002

Structurei

3D structure databases

ProteinModelPortaliP44446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IQE Bacteria
COG1022 LUCA
KOiK01897
OMAiSVLPIWH
PhylomeDBiP44446

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P44446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE
60 70 80 90 100
QLNQLSRALL AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT
110 120 130 140 150
NTAQQAEFIL NHADVKILFV GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ
160 170 180 190 200
LQQDPLSCTW ESFIKTGSNA QQDELTQRLN QKQLSDLFTI IYTSGTTGEP
210 220 230 240 250
KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE RAWAAYILHR
260 270 280 290 300
GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR
310 320 330 340 350
QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR
360 370 380 390 400
IKMMPCGGAK LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN
410 420 430 440 450
SIGTLMPKAE VKIGENNEIL VRGGMVMKGY YKKPEETAQA FTEDGFLKTG
460 470 480 490 500
DAGEFDEQGN LFITDRIKEL MKTSNGKYIA PQYIESKIGK DKFIEQIAII
510 520 530 540 550
ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD ILKMFEHRIN
560 570 580 590 600
AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA

MYHSQEA
Length:607
Mass (Da):69,694
Last modified:November 1, 1995 - v1
Checksum:i111A5AA7A545D674
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21681.1
PIRiH64041
RefSeqiNP_438175.1, NC_000907.1
WP_005693896.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21681; AAC21681; HI_0002
GeneIDi950897
KEGGihin:HI0002
PATRICifig|71421.8.peg.2

Similar proteinsi

Entry informationi

Entry nameiLCFH_HAEIN
AccessioniPrimary (citable) accession number: P44446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health