P44446 (LCFH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative long-chain-fatty-acid--CoA ligase
EC=6.2.1.3

Alternative name(s):
Long-chain acyl-CoA synthetase
Short name=LACS

Gene names

Ordered Locus Names:

HI_0002

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 607	607	Putative long-chain-fatty-acid--CoA ligase		PRO_0000193123

Sequences

	Sequence		Length	Mass (Da)
	P44446 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 111A5AA7A545D674	FASTA	607	69,694
	10 20 30 40 50 60 MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE QLNQLSRALL 70 80 90 100 110 120 AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT NTAQQAEFIL NHADVKILFV 130 140 150 160 170 180 GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ LQQDPLSCTW ESFIKTGSNA QQDELTQRLN 190 200 210 220 230 240 QKQLSDLFTI IYTSGTTGEP KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE 250 260 270 280 290 300 RAWAAYILHR GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR 310 320 330 340 350 360 QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR IKMMPCGGAK 370 380 390 400 410 420 LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN SIGTLMPKAE VKIGENNEIL 430 440 450 460 470 480 VRGGMVMKGY YKKPEETAQA FTEDGFLKTG DAGEFDEQGN LFITDRIKEL MKTSNGKYIA 490 500 510 520 530 540 PQYIESKIGK DKFIEQIAII ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD 550 560 570 580 590 600 ILKMFEHRIN AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA MYHSQEA

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21681.1.
PIR	H64041.
RefSeq	NP_438175.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44446.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950897.
GenomeReviews	Gene locus HI_0002 in contig L42023_GR.
KEGG	hin:HI0002.
NMPDR	fig|71421.1.peg.2.
PATRIC	20188455. VBIHaeInf48452_0002.
TIGR	HI_0002.
Phylogenomic databases
HOGENOM	HBG721674.
OMA	KLEPAIG.
PhylomeDB	P44446.
ProtClustDB	CLSK870300.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0002-MONOMER.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01897.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LCFH_HAEIN

Accession

Primary (citable) accession number: P44446

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program