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P44446

- LCFH_HAEIN

UniProt

P44446 - LCFH_HAEIN

Protein

Putative long-chain-fatty-acid--CoA ligase

Gene

HI_0002

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase
    Short name:
    LACS
    Gene namesi
    Ordered Locus Names:HI_0002
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Putative long-chain-fatty-acid--CoA ligasePRO_0000193123Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0002.

    Structurei

    3D structure databases

    ProteinModelPortaliP44446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    KOiK01897.
    OMAiFYEKIYA.
    OrthoDBiEOG64FKGZ.
    PhylomeDBiP44446.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE    50
    QLNQLSRALL AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT 100
    NTAQQAEFIL NHADVKILFV GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ 150
    LQQDPLSCTW ESFIKTGSNA QQDELTQRLN QKQLSDLFTI IYTSGTTGEP 200
    KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE RAWAAYILHR 250
    GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR 300
    QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR 350
    IKMMPCGGAK LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN 400
    SIGTLMPKAE VKIGENNEIL VRGGMVMKGY YKKPEETAQA FTEDGFLKTG 450
    DAGEFDEQGN LFITDRIKEL MKTSNGKYIA PQYIESKIGK DKFIEQIAII 500
    ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD ILKMFEHRIN 550
    AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA 600
    MYHSQEA 607
    Length:607
    Mass (Da):69,694
    Last modified:November 1, 1995 - v1
    Checksum:i111A5AA7A545D674
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21681.1.
    PIRiH64041.
    RefSeqiNP_438175.1. NC_000907.1.
    WP_005693896.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21681; AAC21681; HI_0002.
    GeneIDi950897.
    KEGGihin:HI0002.
    PATRICi20188455. VBIHaeInf48452_0002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21681.1 .
    PIRi H64041.
    RefSeqi NP_438175.1. NC_000907.1.
    WP_005693896.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21681 ; AAC21681 ; HI_0002 .
    GeneIDi 950897.
    KEGGi hin:HI0002.
    PATRICi 20188455. VBIHaeInf48452_0002.

    Phylogenomic databases

    eggNOGi COG1022.
    KOi K01897.
    OMAi FYEKIYA.
    OrthoDBi EOG64FKGZ.
    PhylomeDBi P44446.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiLCFH_HAEIN
    AccessioniPrimary (citable) accession number: P44446
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3