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P44439

- PCNB_HAEIN

UniProt

P44439 - PCNB_HAEIN

Protein

Poly(A) polymerase I

Gene

pcnB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.UniRule annotation

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681UniRule annotation
    Active sitei70 – 701UniRule annotation
    Active sitei150 – 1501UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA polyadenylation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase IUniRule annotation (EC:2.7.7.19UniRule annotation)
    Short name:
    PAP IUniRule annotation
    Gene namesi
    Name:pcnBUniRule annotation
    Ordered Locus Names:HI_0063
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Poly(A) polymerase IPRO_0000139093Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0063.

    Structurei

    3D structure databases

    ProteinModelPortaliP44439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0617.
    KOiK00970.
    OMAiRFMAKLD.
    OrthoDBiEOG6PZX7Q.
    PhylomeDBiP44439.

    Family and domain databases

    HAMAPiMF_00957. PolyA_pol.
    InterProiIPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view]
    PfamiPF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01942. pcnB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44439-1 [UniParc]FASTAAdd to Basket

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    MPKARAKKSE QTRRYDKNVI KAAQFDISPR DFSRNALNVV EKLQRQGFEA    50
    YIVGGCIRDL LLGKKPKDFD VATNARPEQI QNIFQRQCRL VGRRFRLAHI 100
    MFGRDIIEVA TFRANHSDAR NENQAKQSNE GMLLRDNVYG TIEQDAARRD 150
    FTVNALYYNP QDNTLRDYFE GIKDLKAGKL RLIGDPVTRY QEDPVRMLRS 200
    IRFMAKLDMF LEKPSEQPIR ELAPLLKNIP PARLFDESLK LLQAGQGVKT 250
    YRLLRQYGLF EQLFPALSAY FTEKEDSFAE RMIVTALTST DERVADKLRI 300
    NPAFLFAAFF WYPLREKVEI LKNEGGLNNH DAYALAGNEV LDLFCRALAA 350
    PRRHTAVIRD IWFLQLQLLK RTGSAPMRTM EHPKFRAGFD LLAMRAEIEG 400
    GETIELAKWW HEYQFSNGEQ REQLIQEQQR LHPKPKKKYY RPRRRKTTCS 450
    AE 452
    Length:452
    Mass (Da):52,698
    Last modified:November 1, 1995 - v1
    Checksum:i1B3A9F9E2286F349
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21741.1.
    PIRiB64046.
    RefSeqiNP_438236.1. NC_000907.1.
    WP_010868929.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21741; AAC21741; HI_0063.
    GeneIDi950961.
    KEGGihin:HI0063.
    PATRICi20188581. VBIHaeInf48452_0064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21741.1 .
    PIRi B64046.
    RefSeqi NP_438236.1. NC_000907.1.
    WP_010868929.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21741 ; AAC21741 ; HI_0063 .
    GeneIDi 950961.
    KEGGi hin:HI0063.
    PATRICi 20188581. VBIHaeInf48452_0064.

    Phylogenomic databases

    eggNOGi COG0617.
    KOi K00970.
    OMAi RFMAKLD.
    OrthoDBi EOG6PZX7Q.
    PhylomeDBi P44439.

    Family and domain databases

    HAMAPi MF_00957. PolyA_pol.
    InterProi IPR002646. PolA_pol_head_dom.
    IPR010206. PolA_pol_I.
    IPR025866. PolyA_pol_arg_C_dom.
    [Graphical view ]
    Pfami PF01743. PolyA_pol. 1 hit.
    PF12626. PolyA_pol_arg_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01942. pcnB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPCNB_HAEIN
    AccessioniPrimary (citable) accession number: P44439
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3