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P44439 (PCNB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase I

Short name=PAP I
EC=2.7.7.19
Gene names
Name:pcnB
Ordered Locus Names:HI_0063
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control By similarity. HAMAP-Rule MF_00957

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_00957

Sequence similarities

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Poly(A) polymerase I HAMAP-Rule MF_00957
PRO_0000139093

Sites

Active site681 By similarity
Active site701 By similarity
Active site1501 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44439 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1B3A9F9E2286F349

FASTA45252,698
        10         20         30         40         50         60 
MPKARAKKSE QTRRYDKNVI KAAQFDISPR DFSRNALNVV EKLQRQGFEA YIVGGCIRDL 

        70         80         90        100        110        120 
LLGKKPKDFD VATNARPEQI QNIFQRQCRL VGRRFRLAHI MFGRDIIEVA TFRANHSDAR 

       130        140        150        160        170        180 
NENQAKQSNE GMLLRDNVYG TIEQDAARRD FTVNALYYNP QDNTLRDYFE GIKDLKAGKL 

       190        200        210        220        230        240 
RLIGDPVTRY QEDPVRMLRS IRFMAKLDMF LEKPSEQPIR ELAPLLKNIP PARLFDESLK 

       250        260        270        280        290        300 
LLQAGQGVKT YRLLRQYGLF EQLFPALSAY FTEKEDSFAE RMIVTALTST DERVADKLRI 

       310        320        330        340        350        360 
NPAFLFAAFF WYPLREKVEI LKNEGGLNNH DAYALAGNEV LDLFCRALAA PRRHTAVIRD 

       370        380        390        400        410        420 
IWFLQLQLLK RTGSAPMRTM EHPKFRAGFD LLAMRAEIEG GETIELAKWW HEYQFSNGEQ 

       430        440        450 
REQLIQEQQR LHPKPKKKYY RPRRRKTTCS AE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21741.1.
PIRB64046.
RefSeqNP_438236.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21741; AAC21741; HI_0063.
GeneID950961.
KEGGhin:HI0063.
PATRIC20188581. VBIHaeInf48452_0064.

Phylogenomic databases

eggNOGCOG0617.
KOK00970.
OMARFMAKLD.
OrthoDBEOG6PZX7Q.
ProtClustDBCLSK870278.

Family and domain databases

HAMAPMF_00957. PolyA_pol.
InterProIPR026007. PcnB/CCA-adding.
IPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PANTHERPTHR13734:SF5. PTHR13734:SF5. 1 hit.
PfamPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR01942. pcnB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCNB_HAEIN
AccessionPrimary (citable) accession number: P44439
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names