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Protein

Poly(A) polymerase I

Gene

pcnB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.UniRule annotation

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681UniRule annotation
Active sitei70 – 701UniRule annotation
Active sitei150 – 1501UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA polyadenylation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase IUniRule annotation (EC:2.7.7.19UniRule annotation)
Short name:
PAP IUniRule annotation
Gene namesi
Name:pcnBUniRule annotation
Ordered Locus Names:HI_0063
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Poly(A) polymerase IPRO_0000139093Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0063.

Structurei

3D structure databases

ProteinModelPortaliP44439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0617.
KOiK00970.
OMAiRFMAKLD.
OrthoDBiEOG6PZX7Q.
PhylomeDBiP44439.

Family and domain databases

HAMAPiMF_00957. PolyA_pol.
InterProiIPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PfamiPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01942. pcnB. 1 hit.

Sequencei

Sequence statusi: Complete.

P44439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKARAKKSE QTRRYDKNVI KAAQFDISPR DFSRNALNVV EKLQRQGFEA
60 70 80 90 100
YIVGGCIRDL LLGKKPKDFD VATNARPEQI QNIFQRQCRL VGRRFRLAHI
110 120 130 140 150
MFGRDIIEVA TFRANHSDAR NENQAKQSNE GMLLRDNVYG TIEQDAARRD
160 170 180 190 200
FTVNALYYNP QDNTLRDYFE GIKDLKAGKL RLIGDPVTRY QEDPVRMLRS
210 220 230 240 250
IRFMAKLDMF LEKPSEQPIR ELAPLLKNIP PARLFDESLK LLQAGQGVKT
260 270 280 290 300
YRLLRQYGLF EQLFPALSAY FTEKEDSFAE RMIVTALTST DERVADKLRI
310 320 330 340 350
NPAFLFAAFF WYPLREKVEI LKNEGGLNNH DAYALAGNEV LDLFCRALAA
360 370 380 390 400
PRRHTAVIRD IWFLQLQLLK RTGSAPMRTM EHPKFRAGFD LLAMRAEIEG
410 420 430 440 450
GETIELAKWW HEYQFSNGEQ REQLIQEQQR LHPKPKKKYY RPRRRKTTCS

AE
Length:452
Mass (Da):52,698
Last modified:October 31, 1995 - v1
Checksum:i1B3A9F9E2286F349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21741.1.
PIRiB64046.
RefSeqiNP_438236.1. NC_000907.1.
WP_010868929.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21741; AAC21741; HI_0063.
GeneIDi950961.
KEGGihin:HI0063.
PATRICi20188581. VBIHaeInf48452_0064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21741.1.
PIRiB64046.
RefSeqiNP_438236.1. NC_000907.1.
WP_010868929.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21741; AAC21741; HI_0063.
GeneIDi950961.
KEGGihin:HI0063.
PATRICi20188581. VBIHaeInf48452_0064.

Phylogenomic databases

eggNOGiCOG0617.
KOiK00970.
OMAiRFMAKLD.
OrthoDBiEOG6PZX7Q.
PhylomeDBiP44439.

Family and domain databases

HAMAPiMF_00957. PolyA_pol.
InterProiIPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PfamiPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01942. pcnB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPCNB_HAEIN
AccessioniPrimary (citable) accession number: P44439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 3, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.