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P44439

- PCNB_HAEIN

UniProt

P44439 - PCNB_HAEIN

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Protein
Poly(A) polymerase I
Gene
pcnB, HI_0063
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control By similarity.UniRule annotation

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681 By similarity
Active sitei70 – 701 By similarity
Active sitei150 – 1501 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. polynucleotide adenylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA polyadenylation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase I (EC:2.7.7.19)
Short name:
PAP I
Gene namesi
Name:pcnB
Ordered Locus Names:HI_0063
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Poly(A) polymerase IUniRule annotation
PRO_0000139093Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0063.

Structurei

3D structure databases

ProteinModelPortaliP44439.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0617.
KOiK00970.
OMAiRFMAKLD.
OrthoDBiEOG6PZX7Q.
PhylomeDBiP44439.

Family and domain databases

HAMAPiMF_00957. PolyA_pol.
InterProiIPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view]
PfamiPF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01942. pcnB. 1 hit.

Sequencei

Sequence statusi: Complete.

P44439-1 [UniParc]FASTAAdd to Basket

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MPKARAKKSE QTRRYDKNVI KAAQFDISPR DFSRNALNVV EKLQRQGFEA    50
YIVGGCIRDL LLGKKPKDFD VATNARPEQI QNIFQRQCRL VGRRFRLAHI 100
MFGRDIIEVA TFRANHSDAR NENQAKQSNE GMLLRDNVYG TIEQDAARRD 150
FTVNALYYNP QDNTLRDYFE GIKDLKAGKL RLIGDPVTRY QEDPVRMLRS 200
IRFMAKLDMF LEKPSEQPIR ELAPLLKNIP PARLFDESLK LLQAGQGVKT 250
YRLLRQYGLF EQLFPALSAY FTEKEDSFAE RMIVTALTST DERVADKLRI 300
NPAFLFAAFF WYPLREKVEI LKNEGGLNNH DAYALAGNEV LDLFCRALAA 350
PRRHTAVIRD IWFLQLQLLK RTGSAPMRTM EHPKFRAGFD LLAMRAEIEG 400
GETIELAKWW HEYQFSNGEQ REQLIQEQQR LHPKPKKKYY RPRRRKTTCS 450
AE 452
Length:452
Mass (Da):52,698
Last modified:November 1, 1995 - v1
Checksum:i1B3A9F9E2286F349
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21741.1.
PIRiB64046.
RefSeqiNP_438236.1. NC_000907.1.
WP_010868929.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21741; AAC21741; HI_0063.
GeneIDi950961.
KEGGihin:HI0063.
PATRICi20188581. VBIHaeInf48452_0064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21741.1 .
PIRi B64046.
RefSeqi NP_438236.1. NC_000907.1.
WP_010868929.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21741 ; AAC21741 ; HI_0063 .
GeneIDi 950961.
KEGGi hin:HI0063.
PATRICi 20188581. VBIHaeInf48452_0064.

Phylogenomic databases

eggNOGi COG0617.
KOi K00970.
OMAi RFMAKLD.
OrthoDBi EOG6PZX7Q.
PhylomeDBi P44439.

Family and domain databases

HAMAPi MF_00957. PolyA_pol.
InterProi IPR002646. PolA_pol_head_dom.
IPR010206. PolA_pol_I.
IPR025866. PolyA_pol_arg_C_dom.
[Graphical view ]
Pfami PF01743. PolyA_pol. 1 hit.
PF12626. PolyA_pol_arg_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01942. pcnB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPCNB_HAEIN
AccessioniPrimary (citable) accession number: P44439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi