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P44431 (DMA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA adenine methylase

EC=2.1.1.72
Alternative name(s):
DNA adenine methyltransferase
Deoxyadenosyl-methyltransferase
M.HindIV
Gene names
Name:dam
Synonyms:hindIVM
Ordered Locus Names:HI_0209
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286DNA adenine methylase
PRO_0000087996

Sites

Binding site211S-adenosyl-L-methionine By similarity
Binding site251S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site661S-adenosyl-L-methionine By similarity
Binding site1941S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P44431 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BE39C5725AE35DEE

FASTA28633,219
        10         20         30         40         50         60 
MLRPKKQSLK PKLKHRPFLK WAGGKFRLTD EINKAFPNKK NCLIEPFVGA GAVFLNSNFE 

        70         80         90        100        110        120 
RYILADINPD LINLFNIVKX NVDGYIEDCK PIFFADDANT PDYYYAKRRQ FNASTEPFER 

       130        140        150        160        170        180 
SIIFLYLNRF GFNGLCRYNS KNEFNVPFGA YKTHYFPEDE LRYFAHKAQS AVFLCCDFQK 

       190        200        210        220        230        240 
TFEFADKDSV IYCDPPYAPL QQETNFTGYA GNEFGLAQQR ALADLAKSIQ KEKQISILIS 

       250        260        270        280 
NHDTKFTREI YNGAKFKRVK VQRSISQNPE KRVKVKELIA IFGARK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21877.1.
PIRH64054.
RefSeqNP_438378.1. NC_000907.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0209.

Protein family/group databases

REBASE1152. M.HindDam.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21877; AAC21877; HI_0209.
GeneID951117.
KEGGhin:HI0209.
PATRIC20188915. VBIHaeInf48452_0214.

Phylogenomic databases

eggNOGCOG0338.
KOK06223.
OMALYMNRHG.
OrthoDBEOG6CS08V.
ProtClustDBCLSK870403.

Family and domain databases

Gene3D1.10.1020.10. 1 hit.
InterProIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
[Graphical view]
PfamPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSPR00505. D12N6MTFRASE.
TIGRFAMsTIGR00571. dam. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDMA_HAEIN
AccessionPrimary (citable) accession number: P44431
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names