Reviewed,
UniProtKB/Swiss-Prot P44431 (DMA_HAEIN)
Last modified
November 3, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA adenine methylase EC=2.1.1.72 Alternative name(s): M.HindIV Deoxyadenosyl-methyltransferase DNA adenine methyltransferase | ||||||
| Gene names |
| ||||||
| Organism | Haemophilus influenzae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 727 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 286 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. |
| Sequence similarities | Belongs to the N(4)/N(6)-methyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA methylation Inferred from electronic annotation. Source: InterPro DNA replicationInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro site-specific DNA-methyltransferase (adenine-specific) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 286 | 286 | DNA adenine methylase | PRO_0000087996 | |||||
Sites | |||||||||
| Binding site | 21 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 25 | 1 | S-adenosyl-L-methionine; via amide nitrogen By similarity | ||||||
| Binding site | 66 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 194 | 1 | S-adenosyl-L-methionine By similarity | ||||||
Sequences
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References
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
Cross-references
Sequence databases | |
|---|---|
| L42023 Genomic DNA. Translation: AAC21877.1. | |
| PIR | H64054. |
| RefSeq | NP_438378.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2DPM based on UniProtKB P04043. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 951117. |
| GenomeReviews | Gene locus HI0209 in contig L42023_GR. |
| KEGG | hin:HI0209. |
| NMPDR | fig|71421.1.peg.199. |
| TIGR | HI0209. |
Phylogenomic databases | |
| HOGENOM | P44431. |
| OMA | WAGGKFR. |
Enzyme and pathway databases | |
| BioCyc | HINF71421:HI_0209-MON. |
| BRENDA | 2.1.1.72. 109. |
Family and domain databases | |
| InterPro | IPR002294. D12N6_MeTrfase. IPR012326. Dam. IPR002052. DNA_methylase_N6_adenine_CS. IPR012327. MeTrfase_D12. [Graphical view] |
| Pfam | PF02086. MethyltransfD12. 1 hit. [Graphical view] |
| PRINTS | PR00505. D12N6MTFRASE. |
| TIGRFAMs | TIGR00571. dam. 1 hit. |
| PROSITE | PS00092. N6_MTASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DMA_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P44431 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| Restriction enzymes and methylases Classification of restriction enzymes and methylases and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


