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P44431

- DMA_HAEIN

UniProt

P44431 - DMA_HAEIN

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Protein
DNA adenine methylase
Gene
dam, hindIVM, HI_0209
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211S-adenosyl-L-methionine By similarity
Binding sitei25 – 251S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei66 – 661S-adenosyl-L-methionine By similarity
Binding sitei194 – 1941S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi1152. M.HindDam.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA adenine methylase (EC:2.1.1.72)
Alternative name(s):
DNA adenine methyltransferase
Deoxyadenosyl-methyltransferase
M.HindIV
Gene namesi
Name:dam
Synonyms:hindIVM
Ordered Locus Names:HI_0209
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286DNA adenine methylase
PRO_0000087996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0209.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0338.
KOiK06223.
OMAiKFTREIY.
OrthoDBiEOG6CS08V.
PhylomeDBiP44431.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44431-1 [UniParc]FASTAAdd to Basket

« Hide

MLRPKKQSLK PKLKHRPFLK WAGGKFRLTD EINKAFPNKK NCLIEPFVGA    50
GAVFLNSNFE RYILADINPD LINLFNIVKX NVDGYIEDCK PIFFADDANT 100
PDYYYAKRRQ FNASTEPFER SIIFLYLNRF GFNGLCRYNS KNEFNVPFGA 150
YKTHYFPEDE LRYFAHKAQS AVFLCCDFQK TFEFADKDSV IYCDPPYAPL 200
QQETNFTGYA GNEFGLAQQR ALADLAKSIQ KEKQISILIS NHDTKFTREI 250
YNGAKFKRVK VQRSISQNPE KRVKVKELIA IFGARK 286
Length:286
Mass (Da):33,219
Last modified:November 1, 1995 - v1
Checksum:iBE39C5725AE35DEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21877.1.
PIRiH64054.
RefSeqiNP_438378.1. NC_000907.1.
WP_010868957.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21877; AAC21877; HI_0209.
GeneIDi951117.
KEGGihin:HI0209.
PATRICi20188915. VBIHaeInf48452_0214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21877.1 .
PIRi H64054.
RefSeqi NP_438378.1. NC_000907.1.
WP_010868957.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0209.

Protein family/group databases

REBASEi 1152. M.HindDam.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21877 ; AAC21877 ; HI_0209 .
GeneIDi 951117.
KEGGi hin:HI0209.
PATRICi 20188915. VBIHaeInf48452_0214.

Phylogenomic databases

eggNOGi COG0338.
KOi K06223.
OMAi KFTREIY.
OrthoDBi EOG6CS08V.
PhylomeDBi P44431.

Family and domain databases

Gene3Di 1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProi IPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02086. MethyltransfD12. 1 hit.
[Graphical view ]
PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSi PR00505. D12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00571. dam. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDMA_HAEIN
AccessioniPrimary (citable) accession number: P44431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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