Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P44431

- DMA_HAEIN

UniProt

P44431 - DMA_HAEIN

Protein

DNA adenine methylase

Gene

dam

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211S-adenosyl-L-methionineBy similarity
    Binding sitei25 – 251S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei66 – 661S-adenosyl-L-methionineBy similarity
    Binding sitei194 – 1941S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi1152. M.HindDam.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA adenine methylase (EC:2.1.1.72)
    Alternative name(s):
    DNA adenine methyltransferase
    Deoxyadenosyl-methyltransferase
    M.HindIV
    Gene namesi
    Name:dam
    Synonyms:hindIVM
    Ordered Locus Names:HI_0209
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286DNA adenine methylasePRO_0000087996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0209.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0338.
    KOiK06223.
    OMAiKFTREIY.
    OrthoDBiEOG6CS08V.
    PhylomeDBiP44431.

    Family and domain databases

    Gene3Di1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02086. MethyltransfD12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSiPR00505. D12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00571. dam. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44431-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRPKKQSLK PKLKHRPFLK WAGGKFRLTD EINKAFPNKK NCLIEPFVGA    50
    GAVFLNSNFE RYILADINPD LINLFNIVKX NVDGYIEDCK PIFFADDANT 100
    PDYYYAKRRQ FNASTEPFER SIIFLYLNRF GFNGLCRYNS KNEFNVPFGA 150
    YKTHYFPEDE LRYFAHKAQS AVFLCCDFQK TFEFADKDSV IYCDPPYAPL 200
    QQETNFTGYA GNEFGLAQQR ALADLAKSIQ KEKQISILIS NHDTKFTREI 250
    YNGAKFKRVK VQRSISQNPE KRVKVKELIA IFGARK 286
    Length:286
    Mass (Da):33,219
    Last modified:November 1, 1995 - v1
    Checksum:iBE39C5725AE35DEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21877.1.
    PIRiH64054.
    RefSeqiNP_438378.1. NC_000907.1.
    WP_010868957.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21877; AAC21877; HI_0209.
    GeneIDi951117.
    KEGGihin:HI0209.
    PATRICi20188915. VBIHaeInf48452_0214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21877.1 .
    PIRi H64054.
    RefSeqi NP_438378.1. NC_000907.1.
    WP_010868957.1. NC_000907.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0209.

    Protein family/group databases

    REBASEi 1152. M.HindDam.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21877 ; AAC21877 ; HI_0209 .
    GeneIDi 951117.
    KEGGi hin:HI0209.
    PATRICi 20188915. VBIHaeInf48452_0214.

    Phylogenomic databases

    eggNOGi COG0338.
    KOi K06223.
    OMAi KFTREIY.
    OrthoDBi EOG6CS08V.
    PhylomeDBi P44431.

    Family and domain databases

    Gene3Di 1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02086. MethyltransfD12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSi PR00505. D12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00571. dam. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiDMA_HAEIN
    AccessioniPrimary (citable) accession number: P44431
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3