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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Proton donor/acceptorUniRule annotation1
Active sitei154Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei182Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1151-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:HI_1116
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572341 – 223Deoxyribose-phosphate aldolaseAdd BLAST223

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1116.

Structurei

3D structure databases

ProteinModelPortaliP44430.
SMRiP44430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
KOiK01619.
OMAiTACVKPY.
PhylomeDBiP44430.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
PANTHERiPTHR10889. PTHR10889. 1 hit.
PTHR10889:SF1. PTHR10889:SF1. 1 hit.
PfamiView protein in Pfam
PF01791. DeoC. 1 hit.
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiView protein in SMART
SM01133. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

P44430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNQLAQYI DHTALTAEKN EQDISTLCNE AIEHGFYSVC INSAYIPLAK
60 70 80 90 100
EKLAGSNVKI CTVVGFPLGA NLTSVKAFET QESIKAGANE IDMVINVGWI
110 120 130 140 150
KSQKWDEVKQ DIQAVFNACN GTPLKVILET CLLTKDEIVK ACEICKEIGV
160 170 180 190 200
AFVKTSTGFN KGGATVEDVA LMKNTVGNIG VKASGGVRDT ETALAMIKAG
210 220
ATRIGASAGI AIISGTQDTQ STY
Length:223
Mass (Da):23,614
Last modified:November 1, 1995 - v1
Checksum:iF631CACB7768FE18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22770.1.
PIRiH64183.
RefSeqiNP_439273.1. NC_000907.1.
WP_005693439.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22770; AAC22770; HI_1116.
GeneIDi950311.
KEGGihin:HI1116.
PATRICifig|71421.8.peg.1165.

Similar proteinsi

Entry informationi

Entry nameiDEOC_HAEIN
AccessioniPrimary (citable) accession number: P44430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome