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P44430 (DEOC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyribose-phosphate aldolase

Short name=DERA
EC=4.1.2.4
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase
Gene names
Name:deoC
Ordered Locus Names:HI_1116
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP-Rule MF_00114

Catalytic activity

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP-Rule MF_00114

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP-Rule MF_00114

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00114.

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

deoxyribonucleotide catabolic process

Inferred from electronic annotation. Source: InterPro

deoxyribose phosphate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondeoxyribose-phosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Deoxyribose-phosphate aldolase HAMAP-Rule MF_00114
PRO_0000057234

Sites

Active site1541Schiff-base intermediate with acetaldehyde By similarity
Active site1821 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44430 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F631CACB7768FE18

FASTA22323,614
        10         20         30         40         50         60 
MTSNQLAQYI DHTALTAEKN EQDISTLCNE AIEHGFYSVC INSAYIPLAK EKLAGSNVKI 

        70         80         90        100        110        120 
CTVVGFPLGA NLTSVKAFET QESIKAGANE IDMVINVGWI KSQKWDEVKQ DIQAVFNACN 

       130        140        150        160        170        180 
GTPLKVILET CLLTKDEIVK ACEICKEIGV AFVKTSTGFN KGGATVEDVA LMKNTVGNIG 

       190        200        210        220 
VKASGGVRDT ETALAMIKAG ATRIGASAGI AIISGTQDTQ STY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22770.1.
PIRH64183.
RefSeqNP_439273.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22770; AAC22770; HI_1116.
GeneID950311.
KEGGhin:HI1116.
PATRIC20190905. VBIHaeInf48452_1165.

Phylogenomic databases

eggNOGCOG0274.
KOK01619.
OMAYVYEDIR.
OrthoDBEOG6QZMW5.
PhylomeDBP44430.

Enzyme and pathway databases

UniPathwayUPA00002; UER00468.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00114. DeoC_type1.
InterProIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERPTHR10889. PTHR10889. 1 hit.
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF001357. DeoC. 1 hit.
TIGRFAMsTIGR00126. deoC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEOC_HAEIN
AccessionPrimary (citable) accession number: P44430
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names