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P44430

- DEOC_HAEIN

UniProt

P44430 - DEOC_HAEIN

Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

    Catalytic activityi

    2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541Schiff-base intermediate with acetaldehydeBy similarity
    Active sitei182 – 1821By similarity

    GO - Molecular functioni

    1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate catabolic process Source: UniProtKB-HAMAP
    2. deoxyribonucleotide catabolic process Source: InterPro
    3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00002; UER00468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyribose-phosphate aldolase (EC:4.1.2.4)
    Short name:
    DERA
    Alternative name(s):
    2-deoxy-D-ribose 5-phosphate aldolase
    Phosphodeoxyriboaldolase
    Short name:
    Deoxyriboaldolase
    Gene namesi
    Name:deoC
    Ordered Locus Names:HI_1116
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Deoxyribose-phosphate aldolasePRO_0000057234Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1116.

    Structurei

    3D structure databases

    ProteinModelPortaliP44430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0274.
    KOiK01619.
    OMAiYVYEDIR.
    OrthoDBiEOG6QZMW5.
    PhylomeDBiP44430.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00114. DeoC_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view]
    PANTHERiPTHR10889. PTHR10889. 1 hit.
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001357. DeoC. 1 hit.
    TIGRFAMsiTIGR00126. deoC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P44430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSNQLAQYI DHTALTAEKN EQDISTLCNE AIEHGFYSVC INSAYIPLAK    50
    EKLAGSNVKI CTVVGFPLGA NLTSVKAFET QESIKAGANE IDMVINVGWI 100
    KSQKWDEVKQ DIQAVFNACN GTPLKVILET CLLTKDEIVK ACEICKEIGV 150
    AFVKTSTGFN KGGATVEDVA LMKNTVGNIG VKASGGVRDT ETALAMIKAG 200
    ATRIGASAGI AIISGTQDTQ STY 223
    Length:223
    Mass (Da):23,614
    Last modified:November 1, 1995 - v1
    Checksum:iF631CACB7768FE18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22770.1.
    PIRiH64183.
    RefSeqiNP_439273.1. NC_000907.1.
    WP_005693439.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22770; AAC22770; HI_1116.
    GeneIDi950311.
    KEGGihin:HI1116.
    PATRICi20190905. VBIHaeInf48452_1165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22770.1 .
    PIRi H64183.
    RefSeqi NP_439273.1. NC_000907.1.
    WP_005693439.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22770 ; AAC22770 ; HI_1116 .
    GeneIDi 950311.
    KEGGi hin:HI1116.
    PATRICi 20190905. VBIHaeInf48452_1165.

    Phylogenomic databases

    eggNOGi COG0274.
    KOi K01619.
    OMAi YVYEDIR.
    OrthoDBi EOG6QZMW5.
    PhylomeDBi P44430.

    Enzyme and pathway databases

    UniPathwayi UPA00002 ; UER00468 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00114. DeoC_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    IPR028581. DeoC_typeI.
    [Graphical view ]
    PANTHERi PTHR10889. PTHR10889. 1 hit.
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001357. DeoC. 1 hit.
    TIGRFAMsi TIGR00126. deoC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiDEOC_HAEIN
    AccessioniPrimary (citable) accession number: P44430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3