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P44427

- MDH_HAEIN

UniProt

P44427 - MDH_HAEIN

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADBy similarity
Binding sitei81 – 811SubstrateBy similarity
Binding sitei87 – 871SubstrateBy similarity
Binding sitei94 – 941NADBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei153 – 1531SubstrateBy similarity
Active sitei177 – 1771Proton acceptorBy similarity
Binding sitei227 – 2271NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 137NADBy similarity
Nucleotide bindingi117 – 1193NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:HI_1210
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Malate dehydrogenasePRO_0000113306Add
BLAST

Proteomic databases

PRIDEiP44427.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP44427.
SMRiP44427. Positions 1-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

KOiK00024.
OMAiKARGVYN.
OrthoDBiEOG6091FG.
PhylomeDBiP44427.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44427-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVAVLGAAG GIGQALALLL KLQLPAGTDL SLYDIAPVTP GVAVDVSHIP
60 70 80 90 100
TAVNVKGFSG EDPTPALEGA DVVLISAGVA RKPGMDRSDL FNINAGIVRG
110 120 130 140 150
LIEKVAVTCP KACVGIITNP VNTTVAIAAE VLKKAGVYDK RKLFGVTTLD
160 170 180 190 200
VLRSETFVAE LKGLNVSRTS VPVIGGHSGV TILPLLSQVQ YAKWNEDEIE
210 220 230 240 250
PLTKRIQNAG TEVLNAKAGG GSATLSMAQA AARFARSLVK GLSGETVVEC
260 270 280 290 300
TYVEGDGKYA RFFSQPVRLG KEGVEEILPI GPLSNFEQQA LENMLPTLRA
310
DIELGEKFIN G
Length:311
Mass (Da):32,543
Last modified:November 1, 1995 - v1
Checksum:i1311441B90E4EA2C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631P → L in strain: 767 and 794.
Natural varianti64 – 641T → I in strain: 432.
Natural varianti66 – 661A → T in strain: 1124.
Natural varianti107 – 1082VT → TI in strain: 773, 796 and 1231.
Natural varianti107 – 1071V → I in strain: 162, 375, 723, 788, 800, 1008, 1124, 1158, 1180, 1181, 1207, 1233, 1247, a6062, e6158, e6229, e7066, f6237 and 1209.
Natural varianti107 – 1071V → T in strain: a7205, BR355 and e6181.
Natural varianti128 – 1281A → V in strain: c6132.
Natural varianti135 – 1351A → S in strain: a7205.
Natural varianti163 – 1631G → D in strain: f6252.
Natural varianti193 – 1931K → E in strain: 176, 667, a7205, b7017, c1271, c6134, c7424 and c8032.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22864.1.
AF322740 Genomic DNA. Translation: AAK11394.1.
AF322741 Genomic DNA. Translation: AAK11395.1.
AF322742 Genomic DNA. Translation: AAK11396.1.
AF322743 Genomic DNA. Translation: AAK11397.1.
AF322744 Genomic DNA. Translation: AAK11398.1.
AF322745 Genomic DNA. Translation: AAK11399.1.
AF322746 Genomic DNA. Translation: AAK11400.1.
AF322747 Genomic DNA. Translation: AAK11401.1.
AF322748 Genomic DNA. Translation: AAK11402.1.
AF322749 Genomic DNA. Translation: AAK11403.1.
AF322750 Genomic DNA. Translation: AAK11404.1.
AF322751 Genomic DNA. Translation: AAK11405.1.
AF322752 Genomic DNA. Translation: AAK11406.1.
AF322753 Genomic DNA. Translation: AAK11407.1.
AF322754 Genomic DNA. Translation: AAK11408.1.
AF322755 Genomic DNA. Translation: AAK11409.1.
AF322756 Genomic DNA. Translation: AAK11410.1.
AF322757 Genomic DNA. Translation: AAK11411.1.
AF322758 Genomic DNA. Translation: AAK11412.1.
AF322759 Genomic DNA. Translation: AAK11413.1.
AF322760 Genomic DNA. Translation: AAK11414.1.
AF322761 Genomic DNA. Translation: AAK11415.1.
AF322762 Genomic DNA. Translation: AAK11416.1.
AF322763 Genomic DNA. Translation: AAK11417.1.
AF322764 Genomic DNA. Translation: AAK11418.1.
AF322765 Genomic DNA. Translation: AAK11419.1.
AF322766 Genomic DNA. Translation: AAK11420.1.
AF322767 Genomic DNA. Translation: AAK11421.1.
AF322768 Genomic DNA. Translation: AAK11422.1.
AF322769 Genomic DNA. Translation: AAK11423.1.
AF322770 Genomic DNA. Translation: AAK11424.1.
AF322771 Genomic DNA. Translation: AAK11425.1.
AF322772 Genomic DNA. Translation: AAK11426.1.
AF322773 Genomic DNA. Translation: AAK11427.1.
AF322774 Genomic DNA. Translation: AAK11428.1.
AF322775 Genomic DNA. Translation: AAK11429.1.
AF322776 Genomic DNA. Translation: AAK11430.1.
AF536037 Genomic DNA. Translation: AAP19893.1.
AF536038 Genomic DNA. Translation: AAP19894.1.
AF536039 Genomic DNA. Translation: AAP19895.1.
AF536040 Genomic DNA. Translation: AAP19896.1.
AF536041 Genomic DNA. Translation: AAP19897.1.
AF536042 Genomic DNA. Translation: AAP19898.1.
AF536043 Genomic DNA. Translation: AAP19899.1.
AF536044 Genomic DNA. Translation: AAP19900.1.
AF536045 Genomic DNA. Translation: AAP19901.1.
AF536046 Genomic DNA. Translation: AAP19902.1.
AF536047 Genomic DNA. Translation: AAP19903.1.
AF536048 Genomic DNA. Translation: AAP19904.1.
AF536049 Genomic DNA. Translation: AAP19905.1.
AF536050 Genomic DNA. Translation: AAP19906.1.
AY245392 Genomic DNA. Translation: AAP74406.1.
AY245393 Genomic DNA. Translation: AAP74407.1.
AY245394 Genomic DNA. Translation: AAP74408.1.
AY245395 Genomic DNA. Translation: AAP74409.1.
AY245396 Genomic DNA. Translation: AAP74410.1.
AY245397 Genomic DNA. Translation: AAP74411.1.
AY245398 Genomic DNA. Translation: AAP74412.1.
AY245399 Genomic DNA. Translation: AAP74413.1.
AF525726 Genomic DNA. Translation: AAM91960.1.
AF525727 Genomic DNA. Translation: AAM91961.1.
AF525728 Genomic DNA. Translation: AAM91962.1.
AF525729 Genomic DNA. Translation: AAM91963.1.
AF525730 Genomic DNA. Translation: AAM91964.1.
PIRiC64110.
RefSeqiNP_439366.1. NC_000907.1.
WP_005694235.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22864; AAC22864; HI_1210.
GeneIDi950148.
KEGGihin:HI1210.
PATRICi20191099. VBIHaeInf48452_1262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22864.1 .
AF322740 Genomic DNA. Translation: AAK11394.1 .
AF322741 Genomic DNA. Translation: AAK11395.1 .
AF322742 Genomic DNA. Translation: AAK11396.1 .
AF322743 Genomic DNA. Translation: AAK11397.1 .
AF322744 Genomic DNA. Translation: AAK11398.1 .
AF322745 Genomic DNA. Translation: AAK11399.1 .
AF322746 Genomic DNA. Translation: AAK11400.1 .
AF322747 Genomic DNA. Translation: AAK11401.1 .
AF322748 Genomic DNA. Translation: AAK11402.1 .
AF322749 Genomic DNA. Translation: AAK11403.1 .
AF322750 Genomic DNA. Translation: AAK11404.1 .
AF322751 Genomic DNA. Translation: AAK11405.1 .
AF322752 Genomic DNA. Translation: AAK11406.1 .
AF322753 Genomic DNA. Translation: AAK11407.1 .
AF322754 Genomic DNA. Translation: AAK11408.1 .
AF322755 Genomic DNA. Translation: AAK11409.1 .
AF322756 Genomic DNA. Translation: AAK11410.1 .
AF322757 Genomic DNA. Translation: AAK11411.1 .
AF322758 Genomic DNA. Translation: AAK11412.1 .
AF322759 Genomic DNA. Translation: AAK11413.1 .
AF322760 Genomic DNA. Translation: AAK11414.1 .
AF322761 Genomic DNA. Translation: AAK11415.1 .
AF322762 Genomic DNA. Translation: AAK11416.1 .
AF322763 Genomic DNA. Translation: AAK11417.1 .
AF322764 Genomic DNA. Translation: AAK11418.1 .
AF322765 Genomic DNA. Translation: AAK11419.1 .
AF322766 Genomic DNA. Translation: AAK11420.1 .
AF322767 Genomic DNA. Translation: AAK11421.1 .
AF322768 Genomic DNA. Translation: AAK11422.1 .
AF322769 Genomic DNA. Translation: AAK11423.1 .
AF322770 Genomic DNA. Translation: AAK11424.1 .
AF322771 Genomic DNA. Translation: AAK11425.1 .
AF322772 Genomic DNA. Translation: AAK11426.1 .
AF322773 Genomic DNA. Translation: AAK11427.1 .
AF322774 Genomic DNA. Translation: AAK11428.1 .
AF322775 Genomic DNA. Translation: AAK11429.1 .
AF322776 Genomic DNA. Translation: AAK11430.1 .
AF536037 Genomic DNA. Translation: AAP19893.1 .
AF536038 Genomic DNA. Translation: AAP19894.1 .
AF536039 Genomic DNA. Translation: AAP19895.1 .
AF536040 Genomic DNA. Translation: AAP19896.1 .
AF536041 Genomic DNA. Translation: AAP19897.1 .
AF536042 Genomic DNA. Translation: AAP19898.1 .
AF536043 Genomic DNA. Translation: AAP19899.1 .
AF536044 Genomic DNA. Translation: AAP19900.1 .
AF536045 Genomic DNA. Translation: AAP19901.1 .
AF536046 Genomic DNA. Translation: AAP19902.1 .
AF536047 Genomic DNA. Translation: AAP19903.1 .
AF536048 Genomic DNA. Translation: AAP19904.1 .
AF536049 Genomic DNA. Translation: AAP19905.1 .
AF536050 Genomic DNA. Translation: AAP19906.1 .
AY245392 Genomic DNA. Translation: AAP74406.1 .
AY245393 Genomic DNA. Translation: AAP74407.1 .
AY245394 Genomic DNA. Translation: AAP74408.1 .
AY245395 Genomic DNA. Translation: AAP74409.1 .
AY245396 Genomic DNA. Translation: AAP74410.1 .
AY245397 Genomic DNA. Translation: AAP74411.1 .
AY245398 Genomic DNA. Translation: AAP74412.1 .
AY245399 Genomic DNA. Translation: AAP74413.1 .
AF525726 Genomic DNA. Translation: AAM91960.1 .
AF525727 Genomic DNA. Translation: AAM91961.1 .
AF525728 Genomic DNA. Translation: AAM91962.1 .
AF525729 Genomic DNA. Translation: AAM91963.1 .
AF525730 Genomic DNA. Translation: AAM91964.1 .
PIRi C64110.
RefSeqi NP_439366.1. NC_000907.1.
WP_005694235.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44427.
SMRi P44427. Positions 1-310.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P44427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22864 ; AAC22864 ; HI_1210 .
GeneIDi 950148.
KEGGi hin:HI1210.
PATRICi 20191099. VBIHaeInf48452_1262.

Phylogenomic databases

KOi K00024.
OMAi KARGVYN.
OrthoDBi EOG6091FG.
PhylomeDBi P44427.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01516. Malate_dehydrog_1.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Recombination within natural populations of pathogenic bacteria: Short-term empirical estimates and long-term phylogenetic consequences."
    Feil E.J., Holmes E.C., Bessen D.E., Chan M.-S., Day N.P.J., Enright M.C., Goldstein R., Hood D.W., Kalia A., Moore C.E., Zhou J., Spratt B.G.
    Proc. Natl. Acad. Sci. U.S.A. 98:182-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
    Strain: 1124, 1158, 1181, 1209, 375, 477, 667, 723, a1042, a6062, a6064, a6073, a7190, a7205, b1324, b6107, b7017, b7109, b7651, b7717, Beagan, c1271, c6132, c6134, c7424, c8032, d6137, Drm118, e6158, e6181, e6229, e7066, f6237, f6252, f7283 and f7290.
  3. "High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae."
    Cody A.J., Field D., Feil E.J., Stringer S., Deadman M.E., Tsolaki A.G., Gratz B., Bouchet V., Goldstein R., Hood D.W., Moxon E.R.
    Infect. Genet. Evol. 3:57-66(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
    Strain: 1008, 1180, 1200, 1207, 1231, 1233, 1247, 1268, 162, 176, 285, 432, 486 and 981.
  4. "Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas."
    O'Neill J.M., St Geme J.W. III, Cutter D., Adderson E.E., Anyanwu J., Jacobs R.F., Schutze G.E.
    J. Clin. Microbiol. 41:3064-3069(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
    Strain: 767, 769, 773, 788, 794, 795, 796 and 800.
  5. "Multilocus sequence-typing for characterization of Moscow strains of Haemophilus influenzae type b."
    Platonov A.E., Mironov K.O., Iatsyshina S.B., Koroleva I.S., Platonova O.V., Gushchin A.E., Shipulin G.A.
    Mol. Genet. Mikrobiol. Virusol. 2:21-25(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
    Strain: BR134, BR229, BR355, BR48 and BRC1-13.

Entry informationi

Entry nameiMDH_HAEIN
AccessioniPrimary (citable) accession number: P44427
Secondary accession number(s): Q7WRT7
, Q83V59, Q83V60, Q99Q89, Q99Q90, Q99QA9, Q9AMQ2, Q9AMQ3, Q9AMQ4, Q9AMQ5, Q9AMQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3