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P44427

- MDH_HAEIN

UniProt

P44427 - MDH_HAEIN

Protein

Malate dehydrogenase

Gene

mdh

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADBy similarity
    Binding sitei81 – 811SubstrateBy similarity
    Binding sitei87 – 871SubstrateBy similarity
    Binding sitei94 – 941NADBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei153 – 1531SubstrateBy similarity
    Active sitei177 – 1771Proton acceptorBy similarity
    Binding sitei227 – 2271NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 137NADBy similarity
    Nucleotide bindingi117 – 1193NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:HI_1210
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Malate dehydrogenasePRO_0000113306Add
    BLAST

    Proteomic databases

    PRIDEiP44427.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP44427.
    SMRiP44427. Positions 1-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Phylogenomic databases

    KOiK00024.
    OMAiKARGVYN.
    OrthoDBiEOG6091FG.
    PhylomeDBiP44427.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01516. Malate_dehydrog_1.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR023958. Malate_DH_type1_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44427-1 [UniParc]FASTAAdd to Basket

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    MKVAVLGAAG GIGQALALLL KLQLPAGTDL SLYDIAPVTP GVAVDVSHIP    50
    TAVNVKGFSG EDPTPALEGA DVVLISAGVA RKPGMDRSDL FNINAGIVRG 100
    LIEKVAVTCP KACVGIITNP VNTTVAIAAE VLKKAGVYDK RKLFGVTTLD 150
    VLRSETFVAE LKGLNVSRTS VPVIGGHSGV TILPLLSQVQ YAKWNEDEIE 200
    PLTKRIQNAG TEVLNAKAGG GSATLSMAQA AARFARSLVK GLSGETVVEC 250
    TYVEGDGKYA RFFSQPVRLG KEGVEEILPI GPLSNFEQQA LENMLPTLRA 300
    DIELGEKFIN G 311
    Length:311
    Mass (Da):32,543
    Last modified:November 1, 1995 - v1
    Checksum:i1311441B90E4EA2C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631P → L in strain: 767 and 794.
    Natural varianti64 – 641T → I in strain: 432.
    Natural varianti66 – 661A → T in strain: 1124.
    Natural varianti107 – 1082VT → TI in strain: 773, 796 and 1231.
    Natural varianti107 – 1071V → I in strain: 162, 375, 723, 788, 800, 1008, 1124, 1158, 1180, 1181, 1207, 1233, 1247, a6062, e6158, e6229, e7066, f6237 and 1209.
    Natural varianti107 – 1071V → T in strain: a7205, BR355 and e6181.
    Natural varianti128 – 1281A → V in strain: c6132.
    Natural varianti135 – 1351A → S in strain: a7205.
    Natural varianti163 – 1631G → D in strain: f6252.
    Natural varianti193 – 1931K → E in strain: 176, 667, a7205, b7017, c1271, c6134, c7424 and c8032.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22864.1.
    AF322740 Genomic DNA. Translation: AAK11394.1.
    AF322741 Genomic DNA. Translation: AAK11395.1.
    AF322742 Genomic DNA. Translation: AAK11396.1.
    AF322743 Genomic DNA. Translation: AAK11397.1.
    AF322744 Genomic DNA. Translation: AAK11398.1.
    AF322745 Genomic DNA. Translation: AAK11399.1.
    AF322746 Genomic DNA. Translation: AAK11400.1.
    AF322747 Genomic DNA. Translation: AAK11401.1.
    AF322748 Genomic DNA. Translation: AAK11402.1.
    AF322749 Genomic DNA. Translation: AAK11403.1.
    AF322750 Genomic DNA. Translation: AAK11404.1.
    AF322751 Genomic DNA. Translation: AAK11405.1.
    AF322752 Genomic DNA. Translation: AAK11406.1.
    AF322753 Genomic DNA. Translation: AAK11407.1.
    AF322754 Genomic DNA. Translation: AAK11408.1.
    AF322755 Genomic DNA. Translation: AAK11409.1.
    AF322756 Genomic DNA. Translation: AAK11410.1.
    AF322757 Genomic DNA. Translation: AAK11411.1.
    AF322758 Genomic DNA. Translation: AAK11412.1.
    AF322759 Genomic DNA. Translation: AAK11413.1.
    AF322760 Genomic DNA. Translation: AAK11414.1.
    AF322761 Genomic DNA. Translation: AAK11415.1.
    AF322762 Genomic DNA. Translation: AAK11416.1.
    AF322763 Genomic DNA. Translation: AAK11417.1.
    AF322764 Genomic DNA. Translation: AAK11418.1.
    AF322765 Genomic DNA. Translation: AAK11419.1.
    AF322766 Genomic DNA. Translation: AAK11420.1.
    AF322767 Genomic DNA. Translation: AAK11421.1.
    AF322768 Genomic DNA. Translation: AAK11422.1.
    AF322769 Genomic DNA. Translation: AAK11423.1.
    AF322770 Genomic DNA. Translation: AAK11424.1.
    AF322771 Genomic DNA. Translation: AAK11425.1.
    AF322772 Genomic DNA. Translation: AAK11426.1.
    AF322773 Genomic DNA. Translation: AAK11427.1.
    AF322774 Genomic DNA. Translation: AAK11428.1.
    AF322775 Genomic DNA. Translation: AAK11429.1.
    AF322776 Genomic DNA. Translation: AAK11430.1.
    AF536037 Genomic DNA. Translation: AAP19893.1.
    AF536038 Genomic DNA. Translation: AAP19894.1.
    AF536039 Genomic DNA. Translation: AAP19895.1.
    AF536040 Genomic DNA. Translation: AAP19896.1.
    AF536041 Genomic DNA. Translation: AAP19897.1.
    AF536042 Genomic DNA. Translation: AAP19898.1.
    AF536043 Genomic DNA. Translation: AAP19899.1.
    AF536044 Genomic DNA. Translation: AAP19900.1.
    AF536045 Genomic DNA. Translation: AAP19901.1.
    AF536046 Genomic DNA. Translation: AAP19902.1.
    AF536047 Genomic DNA. Translation: AAP19903.1.
    AF536048 Genomic DNA. Translation: AAP19904.1.
    AF536049 Genomic DNA. Translation: AAP19905.1.
    AF536050 Genomic DNA. Translation: AAP19906.1.
    AY245392 Genomic DNA. Translation: AAP74406.1.
    AY245393 Genomic DNA. Translation: AAP74407.1.
    AY245394 Genomic DNA. Translation: AAP74408.1.
    AY245395 Genomic DNA. Translation: AAP74409.1.
    AY245396 Genomic DNA. Translation: AAP74410.1.
    AY245397 Genomic DNA. Translation: AAP74411.1.
    AY245398 Genomic DNA. Translation: AAP74412.1.
    AY245399 Genomic DNA. Translation: AAP74413.1.
    AF525726 Genomic DNA. Translation: AAM91960.1.
    AF525727 Genomic DNA. Translation: AAM91961.1.
    AF525728 Genomic DNA. Translation: AAM91962.1.
    AF525729 Genomic DNA. Translation: AAM91963.1.
    AF525730 Genomic DNA. Translation: AAM91964.1.
    PIRiC64110.
    RefSeqiNP_439366.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22864; AAC22864; HI_1210.
    GeneIDi950148.
    KEGGihin:HI1210.
    PATRICi20191099. VBIHaeInf48452_1262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22864.1 .
    AF322740 Genomic DNA. Translation: AAK11394.1 .
    AF322741 Genomic DNA. Translation: AAK11395.1 .
    AF322742 Genomic DNA. Translation: AAK11396.1 .
    AF322743 Genomic DNA. Translation: AAK11397.1 .
    AF322744 Genomic DNA. Translation: AAK11398.1 .
    AF322745 Genomic DNA. Translation: AAK11399.1 .
    AF322746 Genomic DNA. Translation: AAK11400.1 .
    AF322747 Genomic DNA. Translation: AAK11401.1 .
    AF322748 Genomic DNA. Translation: AAK11402.1 .
    AF322749 Genomic DNA. Translation: AAK11403.1 .
    AF322750 Genomic DNA. Translation: AAK11404.1 .
    AF322751 Genomic DNA. Translation: AAK11405.1 .
    AF322752 Genomic DNA. Translation: AAK11406.1 .
    AF322753 Genomic DNA. Translation: AAK11407.1 .
    AF322754 Genomic DNA. Translation: AAK11408.1 .
    AF322755 Genomic DNA. Translation: AAK11409.1 .
    AF322756 Genomic DNA. Translation: AAK11410.1 .
    AF322757 Genomic DNA. Translation: AAK11411.1 .
    AF322758 Genomic DNA. Translation: AAK11412.1 .
    AF322759 Genomic DNA. Translation: AAK11413.1 .
    AF322760 Genomic DNA. Translation: AAK11414.1 .
    AF322761 Genomic DNA. Translation: AAK11415.1 .
    AF322762 Genomic DNA. Translation: AAK11416.1 .
    AF322763 Genomic DNA. Translation: AAK11417.1 .
    AF322764 Genomic DNA. Translation: AAK11418.1 .
    AF322765 Genomic DNA. Translation: AAK11419.1 .
    AF322766 Genomic DNA. Translation: AAK11420.1 .
    AF322767 Genomic DNA. Translation: AAK11421.1 .
    AF322768 Genomic DNA. Translation: AAK11422.1 .
    AF322769 Genomic DNA. Translation: AAK11423.1 .
    AF322770 Genomic DNA. Translation: AAK11424.1 .
    AF322771 Genomic DNA. Translation: AAK11425.1 .
    AF322772 Genomic DNA. Translation: AAK11426.1 .
    AF322773 Genomic DNA. Translation: AAK11427.1 .
    AF322774 Genomic DNA. Translation: AAK11428.1 .
    AF322775 Genomic DNA. Translation: AAK11429.1 .
    AF322776 Genomic DNA. Translation: AAK11430.1 .
    AF536037 Genomic DNA. Translation: AAP19893.1 .
    AF536038 Genomic DNA. Translation: AAP19894.1 .
    AF536039 Genomic DNA. Translation: AAP19895.1 .
    AF536040 Genomic DNA. Translation: AAP19896.1 .
    AF536041 Genomic DNA. Translation: AAP19897.1 .
    AF536042 Genomic DNA. Translation: AAP19898.1 .
    AF536043 Genomic DNA. Translation: AAP19899.1 .
    AF536044 Genomic DNA. Translation: AAP19900.1 .
    AF536045 Genomic DNA. Translation: AAP19901.1 .
    AF536046 Genomic DNA. Translation: AAP19902.1 .
    AF536047 Genomic DNA. Translation: AAP19903.1 .
    AF536048 Genomic DNA. Translation: AAP19904.1 .
    AF536049 Genomic DNA. Translation: AAP19905.1 .
    AF536050 Genomic DNA. Translation: AAP19906.1 .
    AY245392 Genomic DNA. Translation: AAP74406.1 .
    AY245393 Genomic DNA. Translation: AAP74407.1 .
    AY245394 Genomic DNA. Translation: AAP74408.1 .
    AY245395 Genomic DNA. Translation: AAP74409.1 .
    AY245396 Genomic DNA. Translation: AAP74410.1 .
    AY245397 Genomic DNA. Translation: AAP74411.1 .
    AY245398 Genomic DNA. Translation: AAP74412.1 .
    AY245399 Genomic DNA. Translation: AAP74413.1 .
    AF525726 Genomic DNA. Translation: AAM91960.1 .
    AF525727 Genomic DNA. Translation: AAM91961.1 .
    AF525728 Genomic DNA. Translation: AAM91962.1 .
    AF525729 Genomic DNA. Translation: AAM91963.1 .
    AF525730 Genomic DNA. Translation: AAM91964.1 .
    PIRi C64110.
    RefSeqi NP_439366.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44427.
    SMRi P44427. Positions 1-310.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P44427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22864 ; AAC22864 ; HI_1210 .
    GeneIDi 950148.
    KEGGi hin:HI1210.
    PATRICi 20191099. VBIHaeInf48452_1262.

    Phylogenomic databases

    KOi K00024.
    OMAi KARGVYN.
    OrthoDBi EOG6091FG.
    PhylomeDBi P44427.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01516. Malate_dehydrog_1.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR023958. Malate_DH_type1_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Recombination within natural populations of pathogenic bacteria: Short-term empirical estimates and long-term phylogenetic consequences."
      Feil E.J., Holmes E.C., Bessen D.E., Chan M.-S., Day N.P.J., Enright M.C., Goldstein R., Hood D.W., Kalia A., Moore C.E., Zhou J., Spratt B.G.
      Proc. Natl. Acad. Sci. U.S.A. 98:182-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
      Strain: 1124, 1158, 1181, 1209, 375, 477, 667, 723, a1042, a6062, a6064, a6073, a7190, a7205, b1324, b6107, b7017, b7109, b7651, b7717, Beagan, c1271, c6132, c6134, c7424, c8032, d6137, Drm118, e6158, e6181, e6229, e7066, f6237, f6252, f7283 and f7290.
    3. "High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae."
      Cody A.J., Field D., Feil E.J., Stringer S., Deadman M.E., Tsolaki A.G., Gratz B., Bouchet V., Goldstein R., Hood D.W., Moxon E.R.
      Infect. Genet. Evol. 3:57-66(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
      Strain: 1008, 1180, 1200, 1207, 1231, 1233, 1247, 1268, 162, 176, 285, 432, 486 and 981.
    4. "Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas."
      O'Neill J.M., St Geme J.W. III, Cutter D., Adderson E.E., Anyanwu J., Jacobs R.F., Schutze G.E.
      J. Clin. Microbiol. 41:3064-3069(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
      Strain: 767, 769, 773, 788, 794, 795, 796 and 800.
    5. "Multilocus sequence-typing for characterization of Moscow strains of Haemophilus influenzae type b."
      Platonov A.E., Mironov K.O., Iatsyshina S.B., Koroleva I.S., Platonova O.V., Gushchin A.E., Shipulin G.A.
      Mol. Genet. Mikrobiol. Virusol. 2:21-25(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-195.
      Strain: BR134, BR229, BR355, BR48 and BRC1-13.

    Entry informationi

    Entry nameiMDH_HAEIN
    AccessioniPrimary (citable) accession number: P44427
    Secondary accession number(s): Q7WRT7
    , Q83V59, Q83V60, Q99Q89, Q99Q90, Q99QA9, Q9AMQ2, Q9AMQ3, Q9AMQ4, Q9AMQ5, Q9AMQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3