Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei87SubstrateBy similarity1
Binding sitei94NADBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei153SubstrateBy similarity1
Active sitei177Proton acceptorBy similarity1
Binding sitei227NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADBy similarity7
Nucleotide bindingi117 – 119NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:HI_1210
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133061 – 311Malate dehydrogenaseAdd BLAST311

Proteomic databases

PRIDEiP44427.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1210.

Structurei

3D structure databases

ProteinModelPortaliP44427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
KOiK00024.
OMAiVEVKGFA.
PhylomeDBiP44427.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVLGAAG GIGQALALLL KLQLPAGTDL SLYDIAPVTP GVAVDVSHIP
60 70 80 90 100
TAVNVKGFSG EDPTPALEGA DVVLISAGVA RKPGMDRSDL FNINAGIVRG
110 120 130 140 150
LIEKVAVTCP KACVGIITNP VNTTVAIAAE VLKKAGVYDK RKLFGVTTLD
160 170 180 190 200
VLRSETFVAE LKGLNVSRTS VPVIGGHSGV TILPLLSQVQ YAKWNEDEIE
210 220 230 240 250
PLTKRIQNAG TEVLNAKAGG GSATLSMAQA AARFARSLVK GLSGETVVEC
260 270 280 290 300
TYVEGDGKYA RFFSQPVRLG KEGVEEILPI GPLSNFEQQA LENMLPTLRA
310
DIELGEKFIN G
Length:311
Mass (Da):32,543
Last modified:November 1, 1995 - v1
Checksum:i1311441B90E4EA2C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63P → L in strain: 767 and 794. 1
Natural varianti64T → I in strain: 432. 1
Natural varianti66A → T in strain: 1124. 1
Natural varianti107 – 108VT → TI in strain: 773, 796 and 1231. 2
Natural varianti107V → I in strain: 162, 375, 723, 788, 800, 1008, 1124, 1158, 1180, 1181, 1207, 1233, 1247, a6062, e6158, e6229, e7066, f6237 and 1209. 1
Natural varianti107V → T in strain: a7205, BR355 and e6181. 1
Natural varianti128A → V in strain: c6132. 1
Natural varianti135A → S in strain: a7205. 1
Natural varianti163G → D in strain: f6252. 1
Natural varianti193K → E in strain: 176, 667, a7205, b7017, c1271, c6134, c7424 and c8032. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22864.1.
AF322740 Genomic DNA. Translation: AAK11394.1.
AF322741 Genomic DNA. Translation: AAK11395.1.
AF322742 Genomic DNA. Translation: AAK11396.1.
AF322743 Genomic DNA. Translation: AAK11397.1.
AF322744 Genomic DNA. Translation: AAK11398.1.
AF322745 Genomic DNA. Translation: AAK11399.1.
AF322746 Genomic DNA. Translation: AAK11400.1.
AF322747 Genomic DNA. Translation: AAK11401.1.
AF322748 Genomic DNA. Translation: AAK11402.1.
AF322749 Genomic DNA. Translation: AAK11403.1.
AF322750 Genomic DNA. Translation: AAK11404.1.
AF322751 Genomic DNA. Translation: AAK11405.1.
AF322752 Genomic DNA. Translation: AAK11406.1.
AF322753 Genomic DNA. Translation: AAK11407.1.
AF322754 Genomic DNA. Translation: AAK11408.1.
AF322755 Genomic DNA. Translation: AAK11409.1.
AF322756 Genomic DNA. Translation: AAK11410.1.
AF322757 Genomic DNA. Translation: AAK11411.1.
AF322758 Genomic DNA. Translation: AAK11412.1.
AF322759 Genomic DNA. Translation: AAK11413.1.
AF322760 Genomic DNA. Translation: AAK11414.1.
AF322761 Genomic DNA. Translation: AAK11415.1.
AF322762 Genomic DNA. Translation: AAK11416.1.
AF322763 Genomic DNA. Translation: AAK11417.1.
AF322764 Genomic DNA. Translation: AAK11418.1.
AF322765 Genomic DNA. Translation: AAK11419.1.
AF322766 Genomic DNA. Translation: AAK11420.1.
AF322767 Genomic DNA. Translation: AAK11421.1.
AF322768 Genomic DNA. Translation: AAK11422.1.
AF322769 Genomic DNA. Translation: AAK11423.1.
AF322770 Genomic DNA. Translation: AAK11424.1.
AF322771 Genomic DNA. Translation: AAK11425.1.
AF322772 Genomic DNA. Translation: AAK11426.1.
AF322773 Genomic DNA. Translation: AAK11427.1.
AF322774 Genomic DNA. Translation: AAK11428.1.
AF322775 Genomic DNA. Translation: AAK11429.1.
AF322776 Genomic DNA. Translation: AAK11430.1.
AF536037 Genomic DNA. Translation: AAP19893.1.
AF536038 Genomic DNA. Translation: AAP19894.1.
AF536039 Genomic DNA. Translation: AAP19895.1.
AF536040 Genomic DNA. Translation: AAP19896.1.
AF536041 Genomic DNA. Translation: AAP19897.1.
AF536042 Genomic DNA. Translation: AAP19898.1.
AF536043 Genomic DNA. Translation: AAP19899.1.
AF536044 Genomic DNA. Translation: AAP19900.1.
AF536045 Genomic DNA. Translation: AAP19901.1.
AF536046 Genomic DNA. Translation: AAP19902.1.
AF536047 Genomic DNA. Translation: AAP19903.1.
AF536048 Genomic DNA. Translation: AAP19904.1.
AF536049 Genomic DNA. Translation: AAP19905.1.
AF536050 Genomic DNA. Translation: AAP19906.1.
AY245392 Genomic DNA. Translation: AAP74406.1.
AY245393 Genomic DNA. Translation: AAP74407.1.
AY245394 Genomic DNA. Translation: AAP74408.1.
AY245395 Genomic DNA. Translation: AAP74409.1.
AY245396 Genomic DNA. Translation: AAP74410.1.
AY245397 Genomic DNA. Translation: AAP74411.1.
AY245398 Genomic DNA. Translation: AAP74412.1.
AY245399 Genomic DNA. Translation: AAP74413.1.
AF525726 Genomic DNA. Translation: AAM91960.1.
AF525727 Genomic DNA. Translation: AAM91961.1.
AF525728 Genomic DNA. Translation: AAM91962.1.
AF525729 Genomic DNA. Translation: AAM91963.1.
AF525730 Genomic DNA. Translation: AAM91964.1.
PIRiC64110.
RefSeqiNP_439366.1. NC_000907.1.
WP_005694235.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22864; AAC22864; HI_1210.
GeneIDi950148.
KEGGihin:HI1210.
PATRICi20191099. VBIHaeInf48452_1262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22864.1.
AF322740 Genomic DNA. Translation: AAK11394.1.
AF322741 Genomic DNA. Translation: AAK11395.1.
AF322742 Genomic DNA. Translation: AAK11396.1.
AF322743 Genomic DNA. Translation: AAK11397.1.
AF322744 Genomic DNA. Translation: AAK11398.1.
AF322745 Genomic DNA. Translation: AAK11399.1.
AF322746 Genomic DNA. Translation: AAK11400.1.
AF322747 Genomic DNA. Translation: AAK11401.1.
AF322748 Genomic DNA. Translation: AAK11402.1.
AF322749 Genomic DNA. Translation: AAK11403.1.
AF322750 Genomic DNA. Translation: AAK11404.1.
AF322751 Genomic DNA. Translation: AAK11405.1.
AF322752 Genomic DNA. Translation: AAK11406.1.
AF322753 Genomic DNA. Translation: AAK11407.1.
AF322754 Genomic DNA. Translation: AAK11408.1.
AF322755 Genomic DNA. Translation: AAK11409.1.
AF322756 Genomic DNA. Translation: AAK11410.1.
AF322757 Genomic DNA. Translation: AAK11411.1.
AF322758 Genomic DNA. Translation: AAK11412.1.
AF322759 Genomic DNA. Translation: AAK11413.1.
AF322760 Genomic DNA. Translation: AAK11414.1.
AF322761 Genomic DNA. Translation: AAK11415.1.
AF322762 Genomic DNA. Translation: AAK11416.1.
AF322763 Genomic DNA. Translation: AAK11417.1.
AF322764 Genomic DNA. Translation: AAK11418.1.
AF322765 Genomic DNA. Translation: AAK11419.1.
AF322766 Genomic DNA. Translation: AAK11420.1.
AF322767 Genomic DNA. Translation: AAK11421.1.
AF322768 Genomic DNA. Translation: AAK11422.1.
AF322769 Genomic DNA. Translation: AAK11423.1.
AF322770 Genomic DNA. Translation: AAK11424.1.
AF322771 Genomic DNA. Translation: AAK11425.1.
AF322772 Genomic DNA. Translation: AAK11426.1.
AF322773 Genomic DNA. Translation: AAK11427.1.
AF322774 Genomic DNA. Translation: AAK11428.1.
AF322775 Genomic DNA. Translation: AAK11429.1.
AF322776 Genomic DNA. Translation: AAK11430.1.
AF536037 Genomic DNA. Translation: AAP19893.1.
AF536038 Genomic DNA. Translation: AAP19894.1.
AF536039 Genomic DNA. Translation: AAP19895.1.
AF536040 Genomic DNA. Translation: AAP19896.1.
AF536041 Genomic DNA. Translation: AAP19897.1.
AF536042 Genomic DNA. Translation: AAP19898.1.
AF536043 Genomic DNA. Translation: AAP19899.1.
AF536044 Genomic DNA. Translation: AAP19900.1.
AF536045 Genomic DNA. Translation: AAP19901.1.
AF536046 Genomic DNA. Translation: AAP19902.1.
AF536047 Genomic DNA. Translation: AAP19903.1.
AF536048 Genomic DNA. Translation: AAP19904.1.
AF536049 Genomic DNA. Translation: AAP19905.1.
AF536050 Genomic DNA. Translation: AAP19906.1.
AY245392 Genomic DNA. Translation: AAP74406.1.
AY245393 Genomic DNA. Translation: AAP74407.1.
AY245394 Genomic DNA. Translation: AAP74408.1.
AY245395 Genomic DNA. Translation: AAP74409.1.
AY245396 Genomic DNA. Translation: AAP74410.1.
AY245397 Genomic DNA. Translation: AAP74411.1.
AY245398 Genomic DNA. Translation: AAP74412.1.
AY245399 Genomic DNA. Translation: AAP74413.1.
AF525726 Genomic DNA. Translation: AAM91960.1.
AF525727 Genomic DNA. Translation: AAM91961.1.
AF525728 Genomic DNA. Translation: AAM91962.1.
AF525729 Genomic DNA. Translation: AAM91963.1.
AF525730 Genomic DNA. Translation: AAM91964.1.
PIRiC64110.
RefSeqiNP_439366.1. NC_000907.1.
WP_005694235.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1210.

Proteomic databases

PRIDEiP44427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22864; AAC22864; HI_1210.
GeneIDi950148.
KEGGihin:HI1210.
PATRICi20191099. VBIHaeInf48452_1262.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
KOiK00024.
OMAiVEVKGFA.
PhylomeDBiP44427.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_HAEIN
AccessioniPrimary (citable) accession number: P44427
Secondary accession number(s): Q7WRT7
, Q83V59, Q83V60, Q99Q89, Q99Q90, Q99QA9, Q9AMQ2, Q9AMQ3, Q9AMQ4, Q9AMQ5, Q9AMQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.