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Protein

Diacylglycerol kinase

Gene

dgkA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Recycling of diacylglycerol produced during the turnover of membrane phospholipid.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase (EC:2.7.1.107)
Short name:
DAGK
Alternative name(s):
Diglyceride kinase
Short name:
DGK
Gene namesi
Name:dgkA
Ordered Locus Names:HI_0335
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Topological domaini50 – 545PeriplasmicSequence Analysis
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 9722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Diacylglycerol kinasePRO_0000195263Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0335.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0818.
KOiK00901.
OMAiLEVYLLI.
OrthoDBiEOG60W7XM.
PhylomeDBiP44424.

Family and domain databases

InterProiIPR000829. Diacylglycerol_kinase_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTTGLTHL INSTKYSLQG LKSAFKNETA FRHECFLACI LIPLTFFLGE
60 70 80 90 100
TKIEIILMIS SVLLVMALEL LNSAVETVVD RIGTERHELS GRAKDQGSAS
110
VFIALCIVGI VWGGILFF
Length:118
Mass (Da):13,025
Last modified:October 31, 1995 - v1
Checksum:i649175CBAB159FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21997.1.
PIRiE64062.
RefSeqiNP_438499.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21997; AAC21997; HI_0335.
GeneIDi949443.
KEGGihin:HI0335.
PATRICi20189213. VBIHaeInf48452_0352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21997.1.
PIRiE64062.
RefSeqiNP_438499.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21997; AAC21997; HI_0335.
GeneIDi949443.
KEGGihin:HI0335.
PATRICi20189213. VBIHaeInf48452_0352.

Phylogenomic databases

eggNOGiCOG0818.
KOiK00901.
OMAiLEVYLLI.
OrthoDBiEOG60W7XM.
PhylomeDBiP44424.

Family and domain databases

InterProiIPR000829. Diacylglycerol_kinase_prok.
[Graphical view]
PfamiPF01219. DAGK_prokar. 1 hit.
[Graphical view]
PROSITEiPS01069. DAGK_PROKAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiKDGL_HAEIN
AccessioniPrimary (citable) accession number: P44424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: January 6, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.