Reviewed, UniProtKB/Swiss-Prot P44419 (GLNE_HAEIN)

Names and origin

Protein names

Recommended name:
    Glutamate-ammonia-ligase adenylyltransferase
    EC=2.7.7.42
Alternative name(s):
    [Glutamate--ammonia-ligase] adenylyltransferase
    Glutamine-synthetase adenylyltransferase
      Short name=ATase

Gene names

Name:	glnE
Ordered Locus Names:	HI0069

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	981 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Adenylation and deadenylation of glutamine synthetase By similarity.
Catalytic activity	ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP MF_00802
Sequence similarities	Belongs to the glnE family.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW [glutamate-ammonia-ligase] adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 981	981	Glutamate-ammonia-ligase adenylyltransferase HAMAP MF_00802		PRO_0000209249
Regions
	Region	108 – 324	217	GlnE 1 HAMAP MF_00802
	Region	646 – 866	221	GlnE 2 HAMAP MF_00802

Sequences

	Sequence		Length	Mass (Da)
	P44419-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 8B2B82376B814883	FASTA	981	112,759
	10 20 30 40 50 60 MTALSALIEQ KLQSLGTILC QSFPELSPEK IHEAIQQNSN HPELPVYQLG YAIAMSDFVE 70 80 90 100 110 120 KVLQKYPHLV KQWWEKSPCF ADCTAYIERL NKELANVHDE TALYQTLRQF RNIEMAKLSF 130 140 150 160 170 180 CQSLNLATVE EIFVQLSQLA ESLIIAARDW LYHQACAEIG TPMDEQGNPQ QLYILGMGKL 190 200 210 220 230 240 GGFELNFSSD IDLIFTYPSQ GETSVENTNA RRSVDNGKFF TRLGQRLISA LDEFTSDGFV 250 260 270 280 290 300 YRTDMRLRPF GDSGVLVLSF SAMEQYYQDQ GRDWERYAMI KGRVLGAQTK DPNVSKLKKM 310 320 330 340 350 360 LRPFVYRRYI DFSVIQSLRE MKGKIEREVR RRGLKDNIKL GAGGIREVEF IVQVFQLIRG 370 380 390 400 410 420 GREINLQQHS LLKILPEITK LRLITEQQFH DLRESYIFLR RVENILQAIN DQQTQTLPTD 430 440 450 460 470 480 EIDQIRLVEA CKTFTCLNEN NQTIEKHYPI ENWDDFYRTL QQKQEKVRAV FTQLIGDEQD 490 500 510 520 530 540 ESSQTDSQWQ DFLEADFEDI EQTLLESSVS ENNIDEVLEK LAQFKDGLNH RVIGSRGRDV 550 560 570 580 590 600 LSHLMPTVLA LIFEQENYRT LLPRILNIIE KISSRTTYLE LLLENPRALQ QVIELCAQSQ 610 620 630 640 650 660 LISEQLAHYP ILLDELLNTE ALRHPLPFTQ YPAELHQYLL RLPPDDEEQL IDALRQFKQA 670 680 690 700 710 720 TLLKVAAADI LGALPVMKVS DHLTYLAEAI IEVVVNLAWK QVSSRFGVPE HLQNNEKGFL 730 740 750 760 770 780 VIGYGKLGGI ELGYKSDLDL VFLYDAVESQ TTGGKKVIDS NQFYLRLAQK IVSIFSINTS 790 800 810 820 830 840 AGVLYEADMR LRPSGDAGLI GCSLSAFSHY QLNDAWTWEK QALVRARPVF GESSLKAKFE 850 860 870 880 890 900 HIRQQVLSAS RDIEQLKQDV VEMRKKMFAH LSHSKHSEFN LKTDRGGITD IEFIAQYLML 910 920 930 940 950 960 ANAPKKPQLT KWSDNVRIFD DMAEAKIISQ TDCDTLKQCY VDLRNTIHHL NLLGKSSVVE 970 980 DSEFVKERSF IQAFWDRLFV S

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21747.1.
PIR	G64046.
RefSeq	NP_438242.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950967.
GenomeReviews	Gene locus HI0069 in contig L42023_GR.
KEGG	hin:HI0069.
NMPDR	fig|71421.1.peg.68.
TIGR	HI0069.
Phylogenomic databases
HOGENOM	P44419.
OMA	VLGMGKL
Enzyme and pathway databases
BioCyc	HINF71421:HI_0069-MON.
BRENDA	2.7.7.42. 109.
Family and domain databases
HAMAP	MF_00802. [Tree]
InterPro	IPR005190. GlnE. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
Pfam	PF08335. GlnD_UR_UTase. 1 hit. PF03710. GlnE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLNE_HAEIN

Accession

Primary (citable) accession number: P44419

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)