P44417 (DEOD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purine nucleoside phosphorylase deoD-type
Short name=PNP
EC=2.4.2.1

Gene names

Name:	deoD
Ordered Locus Names:	HI_0518

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. HAMAP MF_01627
Subunit structure	Homohexamer By similarity. HAMAP MF_01627
Sequence similarities	Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	purine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Purine nucleoside phosphorylase deoD-type HAMAP MF_01627		PRO_0000063135

Sequences

	Sequence		Length	Mass (Da)
	P44417 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0C49C06495AFA706	FASTA	238	25,885
	10 20 30 40 50 60 MTPHINAPEG AFADVVLMPG DPLRAKYIAE TFLQDVVEVT NVRNMLGFTG TYKGRKISIM 70 80 90 100 110 120 GHGMGIPSCS IYAKELITEY GVKKIIRVGS CGTVRMDVKV RDVIIGLGAC TDSKVNRIRF 130 140 150 160 170 180 KDNDFAAIAD FDMAQAAVQA AKAKGKVVRV GNLFSADLFY TPDVEMFDVM EKYGILGVEM 190 200 210 220 230 EAAGIYGVAA EYGAKALTIC TVSDHIRTHE QTTAEERQLT FNDMIEIALD SVLIGDAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed: 10675023] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22176.1.
PIR	B64074.
RefSeq	NP_438676.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44417.
SMR	P44417. Positions 2-236.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949650.
GenomeReviews	Gene locus HI_0518 in contig L42023_GR.
KEGG	hin:HI0518.
PATRIC	20189589. VBIHaeInf48452_0537.
TIGR	HI_0518.
Phylogenomic databases
HOGENOM	HBG617197.
OMA	SFETHAF.
ProtClustDB	PRK05819.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0518-MONOMER.
Family and domain databases
HAMAP	MF_01627. Pur_nucleosid_phosp. [Tree]
InterPro	IPR004402. DeoD. IPR018017. Nucleoside_phosphorylase. IPR018016. Nucleoside_phosphorylase_CS. IPR000845. Nucleoside_phosphorylase_d. [Graphical view]
KO	K03784.
PANTHER	PTHR21234. PNP_UDP. 1 hit.
Pfam	PF01048. PNP_UDP_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00107. DeoD. 1 hit.
PROSITE	PS01232. PNP_UDP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEOD_HAEIN

Accession

Primary (citable) accession number: P44417

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program