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P44414

- MTHD_HAEIN

UniProt

P44414 - MTHD_HAEIN

Protein

Probable modification methylase HindII

Gene

hindIIM

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GTYRAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the HindII endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3427. M.HindII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable modification methylase HindII (EC:2.1.1.72)
    Short name:
    M.HindII
    Alternative name(s):
    Adenine-specific methyltransferase HindII
    Gene namesi
    Name:hindIIM
    Ordered Locus Names:HI_0513
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Probable modification methylase HindIIPRO_0000087974Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0513.

    Structurei

    3D structure databases

    ProteinModelPortaliP44414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0827.
    KOiK07317.
    OMAiPCKERIS.
    OrthoDBiEOG61ZTDZ.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR011639. RM_methylase_Eco57I.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF07669. Eco57I. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44414-1 [UniParc]FASTAAdd to Basket

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    MDESKKISLG QFFTPTHIVK YMIGLMTKNK NASILEPSSG NGVFLDSLIQ    50
    LGYTNLTSYE IDGDIISHPF VINSSFITSY DKPQYDSIIG NPPYVRWKNL 100
    SELQKKELKD NSIWKMYCNS LCDYFYIFII KSILQLKVGG ELIFICPDYF 150
    FSTKNAEGLR KFLINNGSFE KIILFNESKV FHGVSSSVVI FKYIKGKNID 200
    NINIINIDSK SPIKSEDIES LGESYYIPRF SSSDVWVTSP NHIKVALDKF 250
    ESYCKTIKKV QPKSLFDDLE FSRIGSVCDI GNGMVSGLDK AFQMNDINYS 300
    ELELLNSICV AKAKHLDAFC FSGYTRYKFI LDDINEDKLI TYFPNFFYEF 350
    NNYKDYLLKR YSYNKYLPYW KWAFLRNFSL FSKNEKKIFV PCKERISKKS 400
    NFRFSLVDEF IYPTQDVTAL YKKENVKESI EYITAYLNSK AVFLWMKYKG 450
    VVKGNVVEFS EKPLANIPFR RIDWQLKSEK KIHDDITNLV RKYLSNKEFS 500
    ILHEINLNLE KLGIKVEI 518
    Length:518
    Mass (Da):60,410
    Last modified:November 1, 1995 - v1
    Checksum:i2E0CAA5B9DBF2EF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22171.1.
    PIRiF64073.
    RefSeqiNP_438671.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22171; AAC22171; HI_0513.
    GeneIDi950799.
    KEGGihin:HI0513.
    PATRICi20189579. VBIHaeInf48452_0532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22171.1 .
    PIRi F64073.
    RefSeqi NP_438671.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0513.

    Protein family/group databases

    REBASEi 3427. M.HindII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22171 ; AAC22171 ; HI_0513 .
    GeneIDi 950799.
    KEGGi hin:HI0513.
    PATRICi 20189579. VBIHaeInf48452_0532.

    Phylogenomic databases

    eggNOGi COG0827.
    KOi K07317.
    OMAi PCKERIS.
    OrthoDBi EOG61ZTDZ.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR011639. RM_methylase_Eco57I.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF07669. Eco57I. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMTHD_HAEIN
    AccessioniPrimary (citable) accession number: P44414
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3