Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P44414 (MTHD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable modification methylase HindII

Short name=M.HindII
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase HindII
Gene names
Name:hindIIM
Ordered Locus Names:HI_0513
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GTYRAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the HindII endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Probable modification methylase HindII
PRO_0000087974

Sequences

Sequence LengthMass (Da)Tools
P44414 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2E0CAA5B9DBF2EF6

FASTA51860,410
        10         20         30         40         50         60 
MDESKKISLG QFFTPTHIVK YMIGLMTKNK NASILEPSSG NGVFLDSLIQ LGYTNLTSYE 

        70         80         90        100        110        120 
IDGDIISHPF VINSSFITSY DKPQYDSIIG NPPYVRWKNL SELQKKELKD NSIWKMYCNS 

       130        140        150        160        170        180 
LCDYFYIFII KSILQLKVGG ELIFICPDYF FSTKNAEGLR KFLINNGSFE KIILFNESKV 

       190        200        210        220        230        240 
FHGVSSSVVI FKYIKGKNID NINIINIDSK SPIKSEDIES LGESYYIPRF SSSDVWVTSP 

       250        260        270        280        290        300 
NHIKVALDKF ESYCKTIKKV QPKSLFDDLE FSRIGSVCDI GNGMVSGLDK AFQMNDINYS 

       310        320        330        340        350        360 
ELELLNSICV AKAKHLDAFC FSGYTRYKFI LDDINEDKLI TYFPNFFYEF NNYKDYLLKR 

       370        380        390        400        410        420 
YSYNKYLPYW KWAFLRNFSL FSKNEKKIFV PCKERISKKS NFRFSLVDEF IYPTQDVTAL 

       430        440        450        460        470        480 
YKKENVKESI EYITAYLNSK AVFLWMKYKG VVKGNVVEFS EKPLANIPFR RIDWQLKSEK 

       490        500        510 
KIHDDITNLV RKYLSNKEFS ILHEINLNLE KLGIKVEI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22171.1.
PIRF64073.
RefSeqNP_438671.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0513.

Protein family/group databases

REBASE3427. M.HindII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22171; AAC22171; HI_0513.
GeneID950799.
KEGGhin:HI0513.
PATRIC20189579. VBIHaeInf48452_0532.

Phylogenomic databases

eggNOGCOG0827.
KOK07317.
OMAPCKERIS.
OrthoDBEOG61ZTDZ.
ProtClustDBCLSK2518360.

Family and domain databases

InterProIPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
[Graphical view]
PfamPF07669. Eco57I. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTHD_HAEIN
AccessionPrimary (citable) accession number: P44414
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names