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P44414

- MTHD_HAEIN

UniProt

P44414 - MTHD_HAEIN

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Protein

Probable modification methylase HindII

Gene
hindIIM, HI_0513
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GTYRAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the HindII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3427. M.HindII.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable modification methylase HindII (EC:2.1.1.72)
Short name:
M.HindII
Alternative name(s):
Adenine-specific methyltransferase HindII
Gene namesi
Name:hindIIM
Ordered Locus Names:HI_0513
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Probable modification methylase HindIIPRO_0000087974Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0513.

Structurei

3D structure databases

ProteinModelPortaliP44414.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0827.
KOiK07317.
OMAiPCKERIS.
OrthoDBiEOG61ZTDZ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF07669. Eco57I. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44414-1 [UniParc]FASTAAdd to Basket

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MDESKKISLG QFFTPTHIVK YMIGLMTKNK NASILEPSSG NGVFLDSLIQ    50
LGYTNLTSYE IDGDIISHPF VINSSFITSY DKPQYDSIIG NPPYVRWKNL 100
SELQKKELKD NSIWKMYCNS LCDYFYIFII KSILQLKVGG ELIFICPDYF 150
FSTKNAEGLR KFLINNGSFE KIILFNESKV FHGVSSSVVI FKYIKGKNID 200
NINIINIDSK SPIKSEDIES LGESYYIPRF SSSDVWVTSP NHIKVALDKF 250
ESYCKTIKKV QPKSLFDDLE FSRIGSVCDI GNGMVSGLDK AFQMNDINYS 300
ELELLNSICV AKAKHLDAFC FSGYTRYKFI LDDINEDKLI TYFPNFFYEF 350
NNYKDYLLKR YSYNKYLPYW KWAFLRNFSL FSKNEKKIFV PCKERISKKS 400
NFRFSLVDEF IYPTQDVTAL YKKENVKESI EYITAYLNSK AVFLWMKYKG 450
VVKGNVVEFS EKPLANIPFR RIDWQLKSEK KIHDDITNLV RKYLSNKEFS 500
ILHEINLNLE KLGIKVEI 518
Length:518
Mass (Da):60,410
Last modified:November 1, 1995 - v1
Checksum:i2E0CAA5B9DBF2EF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22171.1.
PIRiF64073.
RefSeqiNP_438671.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22171; AAC22171; HI_0513.
GeneIDi950799.
KEGGihin:HI0513.
PATRICi20189579. VBIHaeInf48452_0532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22171.1 .
PIRi F64073.
RefSeqi NP_438671.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0513.

Protein family/group databases

REBASEi 3427. M.HindII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22171 ; AAC22171 ; HI_0513 .
GeneIDi 950799.
KEGGi hin:HI0513.
PATRICi 20189579. VBIHaeInf48452_0532.

Phylogenomic databases

eggNOGi COG0827.
KOi K07317.
OMAi PCKERIS.
OrthoDBi EOG61ZTDZ.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF07669. Eco57I. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMTHD_HAEIN
AccessioniPrimary (citable) accession number: P44414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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