ID   T2D2_HAEIN              Reviewed;         258 AA.
AC   P44413;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   13-SEP-2023, entry version 122.
DE   RecName: Full=Type II restriction enzyme HindII {ECO:0000303|PubMed:12654995};
DE            Short=R.HindII;
DE            EC=3.1.21.4;
DE   AltName: Full=Endonuclease HindII;
DE   AltName: Full=Type-2 restriction enzyme HindII;
GN   Name=hindIIR; OrderedLocusNames=HI_0512;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NOMENCLATURE, AND SUBTYPE.
RX   PubMed=12654995; DOI=10.1093/nar/gkg274;
RA   Roberts R.J., Belfort M., Bestor T., Bhagwat A.S., Bickle T.A.,
RA   Bitinaite J., Blumenthal R.M., Degtyarev S.K., Dryden D.T., Dybvig K.,
RA   Firman K., Gromova E.S., Gumport R.I., Halford S.E., Hattman S.,
RA   Heitman J., Hornby D.P., Janulaitis A., Jeltsch A., Josephsen J., Kiss A.,
RA   Klaenhammer T.R., Kobayashi I., Kong H., Krueger D.H., Lacks S.,
RA   Marinus M.G., Miyahara M., Morgan R.D., Murray N.E., Nagaraja V.,
RA   Piekarowicz A., Pingoud A., Raleigh E., Rao D.N., Reich N., Repin V.E.,
RA   Selker E.U., Shaw P.C., Stein D.C., Stoddard B.L., Szybalski W.,
RA   Trautner T.A., Van Etten J.L., Vitor J.M., Wilson G.G., Xu S.Y.;
RT   "A nomenclature for restriction enzymes, DNA methyltransferases, homing
RT   endonucleases and their genes.";
RL   Nucleic Acids Res. 31:1805-1812(2003).
CC   -!- FUNCTION: A P subtype restriction enzyme that recognizes the double-
CC       stranded sequence 5'-GTYRAC-3' and cleaves after Y-3.
CC       {ECO:0000303|PubMed:12654995}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give specific double-
CC         stranded fragments with terminal 5'-phosphates.; EC=3.1.21.4;
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DR   EMBL; L42023; AAC22170.1; -; Genomic_DNA.
DR   PIR; E64073; E64073.
DR   RefSeq; NP_438670.1; NC_000907.1.
DR   AlphaFoldDB; P44413; -.
DR   SMR; P44413; -.
DR   STRING; 71421.HI_0512; -.
DR   REBASE; 1150; HindII.
DR   EnsemblBacteria; AAC22170; AAC22170; HI_0512.
DR   KEGG; hin:HI_0512; -.
DR   PATRIC; fig|71421.8.peg.531; -.
DR   eggNOG; ENOG502ZAYM; Bacteria.
DR   HOGENOM; CLU_1088820_0_0_6; -.
DR   OrthoDB; 1082220at2; -.
DR   BioCyc; HINF71421:G1GJ1-525-MONOMER; -.
DR   PRO; PR:P44413; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0009036; F:type II site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd22329; HincII-like; 1.
DR   Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR015307; Restrct_endonuc_II_HincII.
DR   Pfam; PF09226; Endonuc-HincII; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Restriction system.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..258
FT                   /note="Type II restriction enzyme HindII"
FT                   /id="PRO_0000077320"
SQ   SEQUENCE   258 AA;  29929 MW;  6BE104A1D1B63238 CRC64;
     MSFIKPIYQD INSILIGQKV KRPKSGTLSG HAAGEPFEKL VYKFLKENLS DLTFKQYEYL
     NDLFMKKPAI IGHEARYKLF NSPTLLFLLS RGKAATENWS IENLFEEKQN DTADILLVKD
     QFYELLDVKT RNISKSAQAP NIISAYKLAQ TCAKMIDNKE FDLFDINYLE VDWELNGEDL
     VCVSTSFAEL FKSEPSELYI NWAAAMQIQF HVRDLDQGFN GTREEWAKSY LKHFVTQAEQ
     RAISMIDKFV KPFKKYIL
//