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P44413

- T2D2_HAEIN

UniProt

P44413 - T2D2_HAEIN

Protein

Type-2 restriction enzyme HindII

Gene

hindIIR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Recognizes the double-stranded sequence GTYRAC and cleaves after Y-3.

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Restriction system

    Protein family/group databases

    REBASEi1150. HindII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 restriction enzyme HindII (EC:3.1.21.4)
    Short name:
    R.HindII
    Alternative name(s):
    Endonuclease HindII
    Type II restriction enzyme HindII
    Gene namesi
    Name:hindIIR
    Ordered Locus Names:HI_0512
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 258257Type-2 restriction enzyme HindIIPRO_0000077320Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0512.

    Structurei

    3D structure databases

    ProteinModelPortaliP44413.
    SMRiP44413. Positions 2-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG320573.
    KOiK01155.
    OMAiQNDTADI.
    OrthoDBiEOG6VMTKC.

    Family and domain databases

    Gene3Di3.40.600.10. 1 hit.
    InterProiIPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    IPR015307. Restrct_endonuc_II_HincII.
    [Graphical view]
    PfamiPF09226. Endonuc-HincII. 1 hit.
    [Graphical view]
    SUPFAMiSSF52980. SSF52980. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P44413-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFIKPIYQD INSILIGQKV KRPKSGTLSG HAAGEPFEKL VYKFLKENLS    50
    DLTFKQYEYL NDLFMKKPAI IGHEARYKLF NSPTLLFLLS RGKAATENWS 100
    IENLFEEKQN DTADILLVKD QFYELLDVKT RNISKSAQAP NIISAYKLAQ 150
    TCAKMIDNKE FDLFDINYLE VDWELNGEDL VCVSTSFAEL FKSEPSELYI 200
    NWAAAMQIQF HVRDLDQGFN GTREEWAKSY LKHFVTQAEQ RAISMIDKFV 250
    KPFKKYIL 258
    Length:258
    Mass (Da):29,929
    Last modified:January 23, 2007 - v2
    Checksum:i6BE104A1D1B63238
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22170.1.
    PIRiE64073.
    RefSeqiNP_438670.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22170; AAC22170; HI_0512.
    GeneIDi950710.
    KEGGihin:HI0512.
    PATRICi20189577. VBIHaeInf48452_0531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22170.1 .
    PIRi E64073.
    RefSeqi NP_438670.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44413.
    SMRi P44413. Positions 2-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0512.

    Protein family/group databases

    REBASEi 1150. HindII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22170 ; AAC22170 ; HI_0512 .
    GeneIDi 950710.
    KEGGi hin:HI0512.
    PATRICi 20189577. VBIHaeInf48452_0531.

    Phylogenomic databases

    eggNOGi NOG320573.
    KOi K01155.
    OMAi QNDTADI.
    OrthoDBi EOG6VMTKC.

    Family and domain databases

    Gene3Di 3.40.600.10. 1 hit.
    InterProi IPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    IPR015307. Restrct_endonuc_II_HincII.
    [Graphical view ]
    Pfami PF09226. Endonuc-HincII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52980. SSF52980. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiT2D2_HAEIN
    AccessioniPrimary (citable) accession number: P44413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries

    External Data

    Dasty 3