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P44413

- T2D2_HAEIN

UniProt

P44413 - T2D2_HAEIN

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Protein

Type-2 restriction enzyme HindII

Gene

hindIIR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Recognizes the double-stranded sequence GTYRAC and cleaves after Y-3.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1150. HindII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HindII (EC:3.1.21.4)
Short name:
R.HindII
Alternative name(s):
Endonuclease HindII
Type II restriction enzyme HindII
Gene namesi
Name:hindIIR
Ordered Locus Names:HI_0512
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 258257Type-2 restriction enzyme HindIIPRO_0000077320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0512.

Structurei

3D structure databases

ProteinModelPortaliP44413.
SMRiP44413. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG320573.
KOiK01155.
OMAiQNDTADI.
OrthoDBiEOG6VMTKC.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
InterProiIPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
IPR015307. Restrct_endonuc_II_HincII.
[Graphical view]
PfamiPF09226. Endonuc-HincII. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P44413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFIKPIYQD INSILIGQKV KRPKSGTLSG HAAGEPFEKL VYKFLKENLS
60 70 80 90 100
DLTFKQYEYL NDLFMKKPAI IGHEARYKLF NSPTLLFLLS RGKAATENWS
110 120 130 140 150
IENLFEEKQN DTADILLVKD QFYELLDVKT RNISKSAQAP NIISAYKLAQ
160 170 180 190 200
TCAKMIDNKE FDLFDINYLE VDWELNGEDL VCVSTSFAEL FKSEPSELYI
210 220 230 240 250
NWAAAMQIQF HVRDLDQGFN GTREEWAKSY LKHFVTQAEQ RAISMIDKFV

KPFKKYIL
Length:258
Mass (Da):29,929
Last modified:January 23, 2007 - v2
Checksum:i6BE104A1D1B63238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22170.1.
PIRiE64073.
RefSeqiNP_438670.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22170; AAC22170; HI_0512.
GeneIDi950710.
KEGGihin:HI0512.
PATRICi20189577. VBIHaeInf48452_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22170.1 .
PIRi E64073.
RefSeqi NP_438670.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44413.
SMRi P44413. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0512.

Protein family/group databases

REBASEi 1150. HindII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22170 ; AAC22170 ; HI_0512 .
GeneIDi 950710.
KEGGi hin:HI0512.
PATRICi 20189577. VBIHaeInf48452_0531.

Phylogenomic databases

eggNOGi NOG320573.
KOi K01155.
OMAi QNDTADI.
OrthoDBi EOG6VMTKC.

Family and domain databases

Gene3Di 3.40.600.10. 1 hit.
InterProi IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
IPR015307. Restrct_endonuc_II_HincII.
[Graphical view ]
Pfami PF09226. Endonuc-HincII. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT2D2_HAEIN
AccessioniPrimary (citable) accession number: P44413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3