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P44413 (T2D2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 restriction enzyme HindII

Short name=R.HindII
EC=3.1.21.4
Alternative name(s):
Endonuclease HindII
Type II restriction enzyme HindII
Gene names
Name:hindIIR
Ordered Locus Names:HI_0512
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Recognizes the double-stranded sequence GTYRAC and cleaves after Y-3.

Catalytic activity

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

Ontologies

Keywords
   Biological processRestriction system
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

Type II site-specific deoxyribonuclease activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 258257Type-2 restriction enzyme HindII
PRO_0000077320

Sequences

Sequence LengthMass (Da)Tools
P44413 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6BE104A1D1B63238

FASTA25829,929
        10         20         30         40         50         60 
MSFIKPIYQD INSILIGQKV KRPKSGTLSG HAAGEPFEKL VYKFLKENLS DLTFKQYEYL 

        70         80         90        100        110        120 
NDLFMKKPAI IGHEARYKLF NSPTLLFLLS RGKAATENWS IENLFEEKQN DTADILLVKD 

       130        140        150        160        170        180 
QFYELLDVKT RNISKSAQAP NIISAYKLAQ TCAKMIDNKE FDLFDINYLE VDWELNGEDL 

       190        200        210        220        230        240 
VCVSTSFAEL FKSEPSELYI NWAAAMQIQF HVRDLDQGFN GTREEWAKSY LKHFVTQAEQ 

       250 
RAISMIDKFV KPFKKYIL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22170.1.
PIRE64073.
RefSeqNP_438670.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44413.
SMRP44413. Positions 2-258.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0512.

Protein family/group databases

REBASE1150. HindII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22170; AAC22170; HI_0512.
GeneID950710.
KEGGhin:HI0512.
PATRIC20189577. VBIHaeInf48452_0531.

Phylogenomic databases

eggNOGNOG320573.
KOK01155.
OMAQNDTADI.
OrthoDBEOG6VMTKC.

Family and domain databases

Gene3D3.40.600.10. 1 hit.
InterProIPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
IPR015307. Restrct_endonuc_II_HincII.
[Graphical view]
PfamPF09226. Endonuc-HincII. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
ProtoNetSearch...

Entry information

Entry nameT2D2_HAEIN
AccessionPrimary (citable) accession number: P44413
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names