Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P44410 (UVRA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein A

Short name=UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene names
Name:uvrA
Ordered Locus Names:HI_0249
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205

Subunit structure

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00205.

Sequence similarities

Belongs to the ABC transporter superfamily. UvrA family.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 943943UvrABC system protein A HAMAP-Rule MF_00205
PRO_0000093053

Regions

Domain310 – 587278ABC transporter 1
Domain607 – 937331ABC transporter 2
Nucleotide binding31 – 388ATP Potential
Zinc finger253 – 28028C4-type HAMAP-Rule MF_00205
Nucleotide binding640 – 6478ATP Potential
Zinc finger740 – 76627C4-type HAMAP-Rule MF_00205

Experimental info

Sequence conflict1631V → L in AAC44592. Ref.2
Sequence conflict2361E → D in AAC44592. Ref.2
Sequence conflict4251R → K in AAC44592. Ref.2
Sequence conflict4631I → M in AAC44592. Ref.2
Sequence conflict5141E → Q in AAC44592. Ref.2
Sequence conflict6611A → T in AAC44592. Ref.2
Sequence conflict9281T → E in AAC44592. Ref.2
Sequence conflict935 – 9428FLKPILEK → PL in AAC44592. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P44410 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4DBA0DCFA602D465

FASTA943104,366
        10         20         30         40         50         60 
MENIDIRGAR THNLKNINLT IPRNKLVVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY 

        70         80         90        100        110        120 
ARQFLSLMEK PDVDSIEGLS PAISIEQKST SHNPRSTVGT ITEIYDYLRL LFARVGEPRC 

       130        140        150        160        170        180 
PDHNVPLTAQ TISQMVDKVL SLPEDSKMML LAPVVKNRKG EHVKILENIA AQGYIRARID 

       190        200        210        220        230        240 
GEICDLSDPP KLALQKKHTI EVVVDRFKVR SDLATRLAES FETALELSGG TAIVAEMDNP 

       250        260        270        280        290        300 
KAEELVFSAN FACPHCGYSV PELEPRLFSF NNPAGACPTC DGLGVQQYFD EDRVVQNPTI 

       310        320        330        340        350        360 
SLAGGAVKGW DRRNFYYYQM LTSLAKHYHF DVEAPYESLP KKIQHIIMHG SGKEEIEFQY 

       370        380        390        400        410        420 
MNDRGDVVIR KHPFEGILNN MARRYKETES MSVREELAKN ISNRPCIDCG GSRLRPEARN 

       430        440        450        460        470        480 
VYIGRTNLPI IAEKSIGETL EFFTALSLTG QKAQIAEKIL KEIRERLQFL VNVGLNYLSL 

       490        500        510        520        530        540 
SRSAETLSGG EAQRIRLASQ IGAGLVGVMY VLDEPSIGLH QRDNERLLNT LIHLRNLGNT 

       550        560        570        580        590        600 
VIVVEHDEDA IRAADHIIDI GPGAGVHGGQ VIAQGNADEI MLNPNSITGK FLSGADKIEI 

       610        620        630        640        650        660 
PKKRTALDKK KWLKLKGASG NNLKNVNLDI PVGLFTCVTG VSGSGKSTLI NDTLFPLAQN 

       670        680        690        700        710        720 
ALNRAEKTDY APYQSIEGLE HFDKVIDINQ SPIGRTPRSN PATYTGLFTP IRELFAGVPE 

       730        740        750        760        770        780 
ARARGYNPGR FSFNVRGGRC EACQGDGVLK VEMHFLPDVY VPCDQCKGKR YNRETLEIRY 

       790        800        810        820        830        840 
KGKTIHQVLD MTVEEAREFF DAIPMIARKL QTLMDVGLSY IRLGQSSTTL SGGEAQRVKL 

       850        860        870        880        890        900 
ATELSKRDTG KTLYILDEPT TGLHFADIKQ LLEVLHRLRD QGNTIVVIEH NLDVIKTADW 

       910        920        930        940 
IVDLGPEGGS GGGQIIATGT PEQVAKVTSS HTARFLKPIL EKP 

« Hide

References

« Hide 'large scale' references
[1]"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd."
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. expand/collapse author list , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.
Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]"Isolation and characterization of the Haemophilus influenzae uvrA gene."
de la Morena M.L., Hendrixson D.R., St Geme J.W. III
Gene 177:23-28(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NTHi N187.
[3]"Cloning and sequencing of the Haemophilus influenzae ssb gene encoding single-strand DNA-binding protein."
Jarosik G.P., Hansen E.J.
Gene 146:101-103(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71.
Strain: NTHi TN106.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21915.1.
U33877 Genomic DNA. Translation: AAC44592.1.
U04997 Genomic DNA. Translation: AAA60462.1.
PIRD64057.
RefSeqNP_438418.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44410.
SMRP44410. Positions 1-943.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21915; AAC21915; HI_0249.
GeneID949621.
KEGGhin:HI0249.
PATRIC20189023. VBIHaeInf48452_0264.

Phylogenomic databases

eggNOGCOG0178.
KOK03701.
OMAQHKKVFE.
OrthoDBEOG6QK4PS.
PhylomeDBP44410.

Family and domain databases

Gene3D3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPMF_00205. UvrA.
InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
TIGRFAMsTIGR00630. uvra. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRA_HAEIN
AccessionPrimary (citable) accession number: P44410
Secondary accession number(s): Q48151
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names