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P44410

- UVRA_HAEIN

UniProt

P44410 - UVRA_HAEIN

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Protein
UvrABC system protein A
Gene
uvrA, HI_0249
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATP Reviewed prediction
Zinc fingeri253 – 28028C4-typeUniRule annotation
Add
BLAST
Nucleotide bindingi640 – 6478ATP Reviewed prediction
Zinc fingeri740 – 76627C4-typeUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATPase activity Source: InterPro
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein A
Short name:
UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene namesi
Name:uvrA
Ordered Locus Names:HI_0249
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943UvrABC system protein AUniRule annotation
PRO_0000093053Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Protein-protein interaction databases

STRINGi71421.HI0249.

Structurei

3D structure databases

ProteinModelPortaliP44410.
SMRiP44410. Positions 1-943.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini310 – 587278ABC transporter 1
Add
BLAST
Domaini607 – 937331ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
KOiK03701.
OMAiQHKKVFE.
OrthoDBiEOG6QK4PS.
PhylomeDBiP44410.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44410-1 [UniParc]FASTAAdd to Basket

« Hide

MENIDIRGAR THNLKNINLT IPRNKLVVIT GLSGSGKSSL AFDTLYAEGQ    50
RRYVESLSAY ARQFLSLMEK PDVDSIEGLS PAISIEQKST SHNPRSTVGT 100
ITEIYDYLRL LFARVGEPRC PDHNVPLTAQ TISQMVDKVL SLPEDSKMML 150
LAPVVKNRKG EHVKILENIA AQGYIRARID GEICDLSDPP KLALQKKHTI 200
EVVVDRFKVR SDLATRLAES FETALELSGG TAIVAEMDNP KAEELVFSAN 250
FACPHCGYSV PELEPRLFSF NNPAGACPTC DGLGVQQYFD EDRVVQNPTI 300
SLAGGAVKGW DRRNFYYYQM LTSLAKHYHF DVEAPYESLP KKIQHIIMHG 350
SGKEEIEFQY MNDRGDVVIR KHPFEGILNN MARRYKETES MSVREELAKN 400
ISNRPCIDCG GSRLRPEARN VYIGRTNLPI IAEKSIGETL EFFTALSLTG 450
QKAQIAEKIL KEIRERLQFL VNVGLNYLSL SRSAETLSGG EAQRIRLASQ 500
IGAGLVGVMY VLDEPSIGLH QRDNERLLNT LIHLRNLGNT VIVVEHDEDA 550
IRAADHIIDI GPGAGVHGGQ VIAQGNADEI MLNPNSITGK FLSGADKIEI 600
PKKRTALDKK KWLKLKGASG NNLKNVNLDI PVGLFTCVTG VSGSGKSTLI 650
NDTLFPLAQN ALNRAEKTDY APYQSIEGLE HFDKVIDINQ SPIGRTPRSN 700
PATYTGLFTP IRELFAGVPE ARARGYNPGR FSFNVRGGRC EACQGDGVLK 750
VEMHFLPDVY VPCDQCKGKR YNRETLEIRY KGKTIHQVLD MTVEEAREFF 800
DAIPMIARKL QTLMDVGLSY IRLGQSSTTL SGGEAQRVKL ATELSKRDTG 850
KTLYILDEPT TGLHFADIKQ LLEVLHRLRD QGNTIVVIEH NLDVIKTADW 900
IVDLGPEGGS GGGQIIATGT PEQVAKVTSS HTARFLKPIL EKP 943
Length:943
Mass (Da):104,366
Last modified:November 1, 1995 - v1
Checksum:i4DBA0DCFA602D465
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631V → L in AAC44592. 1 Publication
Sequence conflicti236 – 2361E → D in AAC44592. 1 Publication
Sequence conflicti425 – 4251R → K in AAC44592. 1 Publication
Sequence conflicti463 – 4631I → M in AAC44592. 1 Publication
Sequence conflicti514 – 5141E → Q in AAC44592. 1 Publication
Sequence conflicti661 – 6611A → T in AAC44592. 1 Publication
Sequence conflicti928 – 9281T → E in AAC44592. 1 Publication
Sequence conflicti935 – 9428FLKPILEK → PL in AAC44592. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21915.1.
U33877 Genomic DNA. Translation: AAC44592.1.
U04997 Genomic DNA. Translation: AAA60462.1.
PIRiD64057.
RefSeqiNP_438418.1. NC_000907.1.
WP_005694053.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21915; AAC21915; HI_0249.
GeneIDi949621.
KEGGihin:HI0249.
PATRICi20189023. VBIHaeInf48452_0264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21915.1 .
U33877 Genomic DNA. Translation: AAC44592.1 .
U04997 Genomic DNA. Translation: AAA60462.1 .
PIRi D64057.
RefSeqi NP_438418.1. NC_000907.1.
WP_005694053.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44410.
SMRi P44410. Positions 1-943.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21915 ; AAC21915 ; HI_0249 .
GeneIDi 949621.
KEGGi hin:HI0249.
PATRICi 20189023. VBIHaeInf48452_0264.

Phylogenomic databases

eggNOGi COG0178.
KOi K03701.
OMAi QHKKVFE.
OrthoDBi EOG6QK4PS.
PhylomeDBi P44410.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Isolation and characterization of the Haemophilus influenzae uvrA gene."
    de la Morena M.L., Hendrixson D.R., St Geme J.W. III
    Gene 177:23-28(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NTHi N187.
  3. "Cloning and sequencing of the Haemophilus influenzae ssb gene encoding single-strand DNA-binding protein."
    Jarosik G.P., Hansen E.J.
    Gene 146:101-103(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71.
    Strain: NTHi TN106.

Entry informationi

Entry nameiUVRA_HAEIN
AccessioniPrimary (citable) accession number: P44410
Secondary accession number(s): Q48151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi