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Protein

UvrABC system protein A

Gene

uvrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Zinc fingeri253 – 280C4-typeUniRule annotationAdd BLAST28
Nucleotide bindingi640 – 647ATPUniRule annotation8
Zinc fingeri740 – 766C4-typeUniRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:HI_0249
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930531 – 943UvrABC system protein AAdd BLAST943

Proteomic databases

PRIDEiP44410.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0249.

Structurei

3D structure databases

ProteinModelPortaliP44410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 587ABC transporter 1UniRule annotationAdd BLAST278
Domaini607 – 937ABC transporter 2UniRule annotationAdd BLAST331

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 280C4-typeUniRule annotationAdd BLAST28
Zinc fingeri740 – 766C4-typeUniRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG4105C5U. Bacteria.
COG0178. LUCA.
KOiK03701.
OMAiGAIKGWD.
PhylomeDBiP44410.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA. 1 hit.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENIDIRGAR THNLKNINLT IPRNKLVVIT GLSGSGKSSL AFDTLYAEGQ
60 70 80 90 100
RRYVESLSAY ARQFLSLMEK PDVDSIEGLS PAISIEQKST SHNPRSTVGT
110 120 130 140 150
ITEIYDYLRL LFARVGEPRC PDHNVPLTAQ TISQMVDKVL SLPEDSKMML
160 170 180 190 200
LAPVVKNRKG EHVKILENIA AQGYIRARID GEICDLSDPP KLALQKKHTI
210 220 230 240 250
EVVVDRFKVR SDLATRLAES FETALELSGG TAIVAEMDNP KAEELVFSAN
260 270 280 290 300
FACPHCGYSV PELEPRLFSF NNPAGACPTC DGLGVQQYFD EDRVVQNPTI
310 320 330 340 350
SLAGGAVKGW DRRNFYYYQM LTSLAKHYHF DVEAPYESLP KKIQHIIMHG
360 370 380 390 400
SGKEEIEFQY MNDRGDVVIR KHPFEGILNN MARRYKETES MSVREELAKN
410 420 430 440 450
ISNRPCIDCG GSRLRPEARN VYIGRTNLPI IAEKSIGETL EFFTALSLTG
460 470 480 490 500
QKAQIAEKIL KEIRERLQFL VNVGLNYLSL SRSAETLSGG EAQRIRLASQ
510 520 530 540 550
IGAGLVGVMY VLDEPSIGLH QRDNERLLNT LIHLRNLGNT VIVVEHDEDA
560 570 580 590 600
IRAADHIIDI GPGAGVHGGQ VIAQGNADEI MLNPNSITGK FLSGADKIEI
610 620 630 640 650
PKKRTALDKK KWLKLKGASG NNLKNVNLDI PVGLFTCVTG VSGSGKSTLI
660 670 680 690 700
NDTLFPLAQN ALNRAEKTDY APYQSIEGLE HFDKVIDINQ SPIGRTPRSN
710 720 730 740 750
PATYTGLFTP IRELFAGVPE ARARGYNPGR FSFNVRGGRC EACQGDGVLK
760 770 780 790 800
VEMHFLPDVY VPCDQCKGKR YNRETLEIRY KGKTIHQVLD MTVEEAREFF
810 820 830 840 850
DAIPMIARKL QTLMDVGLSY IRLGQSSTTL SGGEAQRVKL ATELSKRDTG
860 870 880 890 900
KTLYILDEPT TGLHFADIKQ LLEVLHRLRD QGNTIVVIEH NLDVIKTADW
910 920 930 940
IVDLGPEGGS GGGQIIATGT PEQVAKVTSS HTARFLKPIL EKP
Length:943
Mass (Da):104,366
Last modified:November 1, 1995 - v1
Checksum:i4DBA0DCFA602D465
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163V → L in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti236E → D in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti425R → K in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti463I → M in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti514E → Q in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti661A → T in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti928T → E in AAC44592 (PubMed:8921840).Curated1
Sequence conflicti935 – 942FLKPILEK → PL in AAC44592 (PubMed:8921840).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21915.1.
U33877 Genomic DNA. Translation: AAC44592.1.
U04997 Genomic DNA. Translation: AAA60462.1.
PIRiD64057.
RefSeqiNP_438418.1. NC_000907.1.
WP_005694053.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21915; AAC21915; HI_0249.
GeneIDi949621.
KEGGihin:HI0249.
PATRICi20189023. VBIHaeInf48452_0264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21915.1.
U33877 Genomic DNA. Translation: AAC44592.1.
U04997 Genomic DNA. Translation: AAA60462.1.
PIRiD64057.
RefSeqiNP_438418.1. NC_000907.1.
WP_005694053.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0249.

Proteomic databases

PRIDEiP44410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21915; AAC21915; HI_0249.
GeneIDi949621.
KEGGihin:HI0249.
PATRICi20189023. VBIHaeInf48452_0264.

Phylogenomic databases

eggNOGiENOG4105C5U. Bacteria.
COG0178. LUCA.
KOiK03701.
OMAiGAIKGWD.
PhylomeDBiP44410.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA. 1 hit.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRA_HAEIN
AccessioniPrimary (citable) accession number: P44410
Secondary accession number(s): Q48151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.