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P44410

- UVRA_HAEIN

UniProt

P44410 - UVRA_HAEIN

Protein

UvrABC system protein A

Gene

uvrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 388ATPUniRule annotation
    Zinc fingeri253 – 28028C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi640 – 6478ATPUniRule annotation
    Zinc fingeri740 – 76627C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. DNA binding Source: UniProtKB-HAMAP
    4. excinuclease ABC activity Source: UniProtKB-HAMAP
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein AUniRule annotation
    Short name:
    UvrA proteinUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit AUniRule annotation
    Gene namesi
    Name:uvrAUniRule annotation
    Ordered Locus Names:HI_0249
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 943943UvrABC system protein APRO_0000093053Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI0249.

    Structurei

    3D structure databases

    ProteinModelPortaliP44410.
    SMRiP44410. Positions 1-943.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini310 – 587278ABC transporter 1UniRule annotationAdd
    BLAST
    Domaini607 – 937331ABC transporter 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
    Contains 2 ABC transporter domains.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri253 – 28028C4-typeUniRule annotationAdd
    BLAST
    Zinc fingeri740 – 76627C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0178.
    KOiK03701.
    OMAiQHKKVFE.
    OrthoDBiEOG6QK4PS.
    PhylomeDBiP44410.

    Family and domain databases

    Gene3Di3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPiMF_00205. UvrA.
    InterProiIPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00630. uvra. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENIDIRGAR THNLKNINLT IPRNKLVVIT GLSGSGKSSL AFDTLYAEGQ    50
    RRYVESLSAY ARQFLSLMEK PDVDSIEGLS PAISIEQKST SHNPRSTVGT 100
    ITEIYDYLRL LFARVGEPRC PDHNVPLTAQ TISQMVDKVL SLPEDSKMML 150
    LAPVVKNRKG EHVKILENIA AQGYIRARID GEICDLSDPP KLALQKKHTI 200
    EVVVDRFKVR SDLATRLAES FETALELSGG TAIVAEMDNP KAEELVFSAN 250
    FACPHCGYSV PELEPRLFSF NNPAGACPTC DGLGVQQYFD EDRVVQNPTI 300
    SLAGGAVKGW DRRNFYYYQM LTSLAKHYHF DVEAPYESLP KKIQHIIMHG 350
    SGKEEIEFQY MNDRGDVVIR KHPFEGILNN MARRYKETES MSVREELAKN 400
    ISNRPCIDCG GSRLRPEARN VYIGRTNLPI IAEKSIGETL EFFTALSLTG 450
    QKAQIAEKIL KEIRERLQFL VNVGLNYLSL SRSAETLSGG EAQRIRLASQ 500
    IGAGLVGVMY VLDEPSIGLH QRDNERLLNT LIHLRNLGNT VIVVEHDEDA 550
    IRAADHIIDI GPGAGVHGGQ VIAQGNADEI MLNPNSITGK FLSGADKIEI 600
    PKKRTALDKK KWLKLKGASG NNLKNVNLDI PVGLFTCVTG VSGSGKSTLI 650
    NDTLFPLAQN ALNRAEKTDY APYQSIEGLE HFDKVIDINQ SPIGRTPRSN 700
    PATYTGLFTP IRELFAGVPE ARARGYNPGR FSFNVRGGRC EACQGDGVLK 750
    VEMHFLPDVY VPCDQCKGKR YNRETLEIRY KGKTIHQVLD MTVEEAREFF 800
    DAIPMIARKL QTLMDVGLSY IRLGQSSTTL SGGEAQRVKL ATELSKRDTG 850
    KTLYILDEPT TGLHFADIKQ LLEVLHRLRD QGNTIVVIEH NLDVIKTADW 900
    IVDLGPEGGS GGGQIIATGT PEQVAKVTSS HTARFLKPIL EKP 943
    Length:943
    Mass (Da):104,366
    Last modified:November 1, 1995 - v1
    Checksum:i4DBA0DCFA602D465
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631V → L in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti236 – 2361E → D in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti425 – 4251R → K in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti463 – 4631I → M in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti514 – 5141E → Q in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti661 – 6611A → T in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti928 – 9281T → E in AAC44592. (PubMed:8921840)Curated
    Sequence conflicti935 – 9428FLKPILEK → PL in AAC44592. (PubMed:8921840)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21915.1.
    U33877 Genomic DNA. Translation: AAC44592.1.
    U04997 Genomic DNA. Translation: AAA60462.1.
    PIRiD64057.
    RefSeqiNP_438418.1. NC_000907.1.
    WP_005694053.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21915; AAC21915; HI_0249.
    GeneIDi949621.
    KEGGihin:HI0249.
    PATRICi20189023. VBIHaeInf48452_0264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21915.1 .
    U33877 Genomic DNA. Translation: AAC44592.1 .
    U04997 Genomic DNA. Translation: AAA60462.1 .
    PIRi D64057.
    RefSeqi NP_438418.1. NC_000907.1.
    WP_005694053.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44410.
    SMRi P44410. Positions 1-943.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21915 ; AAC21915 ; HI_0249 .
    GeneIDi 949621.
    KEGGi hin:HI0249.
    PATRICi 20189023. VBIHaeInf48452_0264.

    Phylogenomic databases

    eggNOGi COG0178.
    KOi K03701.
    OMAi QHKKVFE.
    OrthoDBi EOG6QK4PS.
    PhylomeDBi P44410.

    Family and domain databases

    Gene3Di 3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPi MF_00205. UvrA.
    InterProi IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00630. uvra. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Isolation and characterization of the Haemophilus influenzae uvrA gene."
      de la Morena M.L., Hendrixson D.R., St Geme J.W. III
      Gene 177:23-28(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NTHi N187.
    3. "Cloning and sequencing of the Haemophilus influenzae ssb gene encoding single-strand DNA-binding protein."
      Jarosik G.P., Hansen E.J.
      Gene 146:101-103(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71.
      Strain: NTHi TN106.

    Entry informationi

    Entry nameiUVRA_HAEIN
    AccessioniPrimary (citable) accession number: P44410
    Secondary accession number(s): Q48151
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3