Reviewed, UniProtKB/Swiss-Prot P44408 (REC2_HAEIN)

Names and origin

Protein names

Recommended name:
    Recombination protein 2

Gene names

Name:	rec2
Synonyms:	rec-2
Ordered Locus Names:	HI0061

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	788 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Might contribute to transformation as a member of a membrane-bound pore complex at the base of the transformasome. It could directly interact with transforming DNA during translocation indirectly by participating in the assembly of the pore.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Biological process	Competence Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	establishment of competence for transformation Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 788	788	Recombination protein 2		PRO_0000097224
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	27 – 47	21	Potential
	Transmembrane	51 – 71	21	Potential
	Transmembrane	226 – 246	21	Potential
	Transmembrane	263 – 283	21	Potential
	Transmembrane	313 – 333	21	Potential
	Transmembrane	367 – 387	21	Potential
	Transmembrane	401 – 421	21	Potential
	Transmembrane	434 – 454	21	Potential
	Transmembrane	456 – 476	21	Potential
	Transmembrane	508 – 528	21	Potential
Experimental info
	Sequence conflict	748 – 788	41	VENTA…GLSKE → GRKYRCFGASAGKFFSRPIR NPASSHKIFPLVCACNWIIK GIKGTMRAIFTIR in AAC13733. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P44408-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: F31104595CB4E47A	FASTA	788	89,356
	10 20 30 40 50 60 MKLNLITLVV LLIVADLTLL FLPQPLLLPW QVALVIALVL IFLFIFLRRN FLVSLAFFVA 70 80 90 100 110 120 SLGYFHYSAL SLSQQAQNIT AQKQVVTFKI QEILHQQDYQ TLIATATLEN NLQEQRIFLN 130 140 150 160 170 180 WKAKEVPQLS EIWQAEISLR SLSARLNFGG FDRQQWYFSK GITAVGTVKS AVKIADVSSL 190 200 210 220 230 240 RAEKLQQVKK QTEGLSLQGL LIALAFGERA WLDKTTWSIY QQTNTAHLIA ISGLHIGLAM 250 260 270 280 290 300 GIGFCLARVV QVFFPTRFIH PYFPLVFGVL FALIYAYLAG FSVPTFRAIS ALVFVLFIQI 310 320 330 340 350 360 MRRHYSPIQF FTLVVGFLLF CDPLMPLSVS FWLSCGAVGC LLLWYRYVPF SLFQWKNRPF 370 380 390 400 410 420 SPKVRWIFSL FHLQFGLLLF FTPLQLFLFN GLSLSGFLAN FMAVPIYSFL LVPLILFAVF 430 440 450 460 470 480 TNGTMFSWQL ANKLAEGITG LISVFQGNWL TVSFNLALGL TALCAGIFML IIWNIYREPE 490 500 510 520 530 540 ISSSNWQIKR AKFFTLNLSK PLLKNERINV LRCSFGIILL CFTILLFKQL SKPTWQVDTL 550 560 570 580 590 600 DVGQGLATLI VKNGKGILYD TGSSWRGGSM AELEILPYLQ REGIVLEKLI LSHDDNDHAG 610 620 630 640 650 660 GASTILKAYP NVELITPSRK NYGENYRTFC TAGRDWHWQG LHFQILSPHN VVTRADNSHS 670 680 690 700 710 720 CVILVDDGKN SVLLTGDAEA KNEQIFARTL GKIDVLQVGH HGSKTSTSEY LLSQVRPDVA 730 740 750 760 770 780 IISSGRWNPW KFPHYSVMER LHRYKSAVEN TAVSGQVRVN FFQDRLEIQQ ARTKFSPWYA RVIGLSKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the rec-2 locus of Haemophilus influenzae: homologies to comE-ORF3 of Bacillus subtilis and msbA of Escherichia coli." Clifton S.W., McCarthy D., Roe B.A. Gene 146:95-100(1994) [PubMed: 8063112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BC200.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L20805 Genomic DNA. Translation: AAC13733.1. L42023 Genomic DNA. Translation: AAC21739.1.
PIR	I64045.
RefSeq	NP_438234.1.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	3.A.11.2.2. bacterial competence-related DNA transformation transporter (DNA-T) family.
Genome annotation databases
GeneID	950960.
GenomeReviews	Gene locus HI0061 in contig L42023_GR.
KEGG	hin:HI0061.
NMPDR	fig|71421.1.peg.60.
TIGR	HI0061.
Phylogenomic databases
HOGENOM	HBG390901.
OMA	HYGRITH.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0061-MON.
Family and domain databases
InterPro	IPR001279. Blactmase-like. IPR004477. ComEC_N-term. IPR004797. Competence_ComEC/Rec2. [Graphical view]
Pfam	PF03772. Competence. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

REC2_HAEIN

Accession

Primary (citable) accession number: P44408

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 15, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)