Lipid A export ATP-binding/permease protein MsbA - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

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P44407 (MSBA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lipid A export ATP-binding/permease protein MsbA
EC=3.6.3.-

Gene names

Name:	msbA
Synonyms:	msh-1
Ordered Locus Names:	HI_0060

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity. HAMAP MF_01703
Subunit structure	Homodimer By similarity. HAMAP MF_01703
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01703.
Domain	In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. HAMAP MF_01703
Sequence similarities	Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 587

587

Lipid A export ATP-binding/permease protein MsbA HAMAP MF_01703

PRO_0000092583

Regions

Transmembrane

31 – 51

Helical; Potential

Transmembrane

68 – 88

Helical; Potential

Transmembrane

145 – 165

Helical; Potential

Transmembrane

166 – 186

Helical; Potential

Transmembrane

259 – 279

Helical; Potential

Domain

31 – 315

285

ABC transmembrane type-1

Domain

347 – 583

237

ABC transporter

Nucleotide binding

381 – 388

ATP By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P44407 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 97F90D5537436123
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FASTA

587

64,912

        10         20         30         40         50         60 
MQEQKLQEND FSTLQTFKRL WPMIKPFKAG LIVSGVALVF NALADSGLIY LLKPLLDDGF 

        70         80         90        100        110        120 
GKANHSFLKM MAFVVVGMII LRGITNFISN YCLAWVSGKV VMTMRRRLFK HLMFMPVSFF 

       130        140        150        160        170        180 
DQNSTGRLLS RITYDSQMIA SSSSGSLITI VREGAYIISL FAVMFYTSWE LTIVLFIIGP 

       190        200        210        220        230        240 
IIAVLIRLVS KIFRRLSKNL QDSMGELTSA TEQMLKGHKV VLSFGGQHVE EVHFNHVSND 

       250        260        270        280        290        300 
MRRKSMKMVT ANSISDPVVQ VIASLALATV LYLATTPLIA EDNLSAGSFT VVFSSMLAMM 

       310        320        330        340        350        360 
RPLKSLTAVN AQFQSGMAAC QTLFAILDLE PEKDDGAYKA EPAKGELEFK NVSFAYQGKD 

       370        380        390        400        410        420 
ELALNNISFS VPAGKTVALV GRSGSGKSTI ANLVTRFYDI EQGEILLDGV NIQDYRLSNL 

       430        440        450        460        470        480 
RENCAVVSQQ VHLFNDTIAN NIAYAAQDKY SREEIIAAAK AAYALEFIEK LPQVFDTVIG 

       490        500        510        520        530        540 
ENGTSLSGGQ RQRLAIARAL LRNSPVLILD EATSALDTES ERAIQSALEE LKKDRTVVVI 

       550        560        570        580 
AHRLSTIENA DEILVIDHGE IRERGNHKTL LEQNGAYKQL HSMQFTG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Sequence of the rec-2 locus of Haemophilus influenzae: homologies to comE-ORF3 of Bacillus subtilis and msbA of Escherichia coli." Clifton S.W., McCarthy D., Roe B.A. Gene 146:95-100(1994) [PubMed: 8063112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-458. Strain: BC200.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21738.1. L20805 Genomic DNA. Translation: AAC13734.1.
PIR	H64045.
RefSeq	NP_438233.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44407.
SMR	P44407. Positions 15-585.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950953.
GenomeReviews	Gene locus HI_0060 in contig L42023_GR.
KEGG	hin:HI0060.
NMPDR	fig\|71421.1.peg.59.
PATRIC	20188573. VBIHaeInf48452_0060.
TIGR	HI_0060.
Phylogenomic databases
HOGENOM	HBG758042.
OMA	MRRRLFK.
PhylomeDB	P44407.
ProtClustDB	PRK11176.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0060-MONOMER.
Family and domain databases
HAMAP	MF_01703. ABC_ATPase_TM_MsbA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR011917. ABC_transpr_lipidA. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K11085.
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
TIGRFAMs	TIGR02203. MsbA_lipidA. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51239. MSBA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSBA_HAEIN

Accession

Primary (citable) accession number: P44407

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents