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Protein

Acetate kinase

Gene

ackA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei147Proton donor/acceptorUniRule annotation1
Sitei179Transition state stabilizerUniRule annotation1
Sitei240Transition state stabilizerUniRule annotation1
Metal bindingi388MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 211ATPUniRule annotation5
Nucleotide bindingi282 – 284ATPUniRule annotation3
Nucleotide bindingi333 – 337ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:HI_1204
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075651 – 401Acetate kinaseAdd BLAST401

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1204.

Structurei

3D structure databases

ProteinModelPortaliP44406.
SMRiP44406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
KOiK00925.
OMAiWKALTGT.
PhylomeDBiP44406.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P44406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLVLILNC GSSSLKFAIL DPATGEEKLS GLAEAFFLPE ARIKWKLNGE
60 70 80 90 100
KGNADLGAGA AHTEALNFIA SNILNDELKN SIAAIGHRIV HGGEKYTQSV
110 120 130 140 150
IVTDEVVKGI EDAAQFAPLH NPAHLIGIRE AFKAFPHLKD KNVVVFDTAF
160 170 180 190 200
HQTMPEEAFL YALPYSLYKE HGVRRYGAHG TSHYFVSREV AKYVGKPADQ
210 220 230 240 250
VNAIICHLGN GGSVSVVRNG QCIDTSMGLT PLEGLVMGTR CGDIDPAIVF
260 270 280 290 300
YLYKTLGMSM DQIEETLVKK SGLLGLTEVT SDCRYAEDNY DDESKPETRR
310 320 330 340 350
ALNVYSYRLA KYIGAYMAVL GDDHLDAIAF TGGIGENSAH VRELALNHLK
360 370 380 390 400
LFGIKIDNER NLATRFGKDG VITTDDSAFK AIVLPTNEEL VIAQDTAKLC

F
Length:401
Mass (Da):43,758
Last modified:November 1, 1995 - v1
Checksum:i4E12E0F67D322E2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22858.1.
PIRiG64189.
RefSeqiNP_439360.1. NC_000907.1.
WP_005694241.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22858; AAC22858; HI_1204.
GeneIDi949638.
KEGGihin:HI1204.
PATRICifig|71421.8.peg.1256.

Similar proteinsi

Entry informationi

Entry nameiACKA_HAEIN
AccessioniPrimary (citable) accession number: P44406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families