P44406 (ACKA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	HI_1204

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically By similarity. HAMAP MF_00020
Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Acetate kinase HAMAP MF_00020		PRO_0000107565

Sequences

	Sequence		Length	Mass (Da)
	P44406 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4E12E0F67D322E2C	FASTA	401	43,758
	10 20 30 40 50 60 MSKLVLILNC GSSSLKFAIL DPATGEEKLS GLAEAFFLPE ARIKWKLNGE KGNADLGAGA 70 80 90 100 110 120 AHTEALNFIA SNILNDELKN SIAAIGHRIV HGGEKYTQSV IVTDEVVKGI EDAAQFAPLH 130 140 150 160 170 180 NPAHLIGIRE AFKAFPHLKD KNVVVFDTAF HQTMPEEAFL YALPYSLYKE HGVRRYGAHG 190 200 210 220 230 240 TSHYFVSREV AKYVGKPADQ VNAIICHLGN GGSVSVVRNG QCIDTSMGLT PLEGLVMGTR 250 260 270 280 290 300 CGDIDPAIVF YLYKTLGMSM DQIEETLVKK SGLLGLTEVT SDCRYAEDNY DDESKPETRR 310 320 330 340 350 360 ALNVYSYRLA KYIGAYMAVL GDDHLDAIAF TGGIGENSAH VRELALNHLK LFGIKIDNER 370 380 390 400 NLATRFGKDG VITTDDSAFK AIVLPTNEEL VIAQDTAKLC F

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22858.1.
PIR	G64189.
RefSeq	NP_439360.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44406.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949638.
GenomeReviews	Gene locus HI_1204 in contig L42023_GR.
KEGG	hin:HI1204.
NMPDR	fig|71421.1.peg.1151.
PATRIC	20191087. VBIHaeInf48452_1256.
TIGR	HI_1204.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	IVFHLHD.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1204-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_HAEIN

Accession

Primary (citable) accession number: P44406

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program