P44393 (URE3_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease subunit gamma
EC=3.5.1.5

Alternative name(s):
Urea amidohydrolase subunit gamma

Gene names

Name:	ureA
Ordered Locus Names:	HI_0541

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_00739
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_00739
Subunit structure	Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00739.
Sequence similarities	Belongs to the urease gamma subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	urea metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 100	100	Urease subunit gamma HAMAP MF_00739		PRO_0000098014

Sequences

	Sequence		Length	Mass (Da)
	P44393 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: DB33B79DF6C84274	FASTA	100	11,097
	10 20 30 40 50 60 MHLTSREQEK LMLFLAGELA AKRKARGVKL NYPETIAYIA SHLQEAAREG MSVAEVMQYG 70 80 90 100 ATLLTVDDVM EGVAEMVHEV QIEATFPDGT KLVTVHNPIR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22199.1.
PIR	A64076.
RefSeq	NP_438699.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44393.
SMR	P44393. Positions 1-99.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949600.
GenomeReviews	Gene locus HI_0541 in contig L42023_GR.
KEGG	hin:HI0541.
NMPDR	fig|71421.1.peg.512.
PATRIC	20189635. VBIHaeInf48452_0560.
TIGR	HI_0541.
Phylogenomic databases
HOGENOM	HBG286300.
OMA	YPEAVAY.
ProtClustDB	PRK13241.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0541-MONOMER.
Family and domain databases
HAMAP	MF_00739. Urease_gamma. [Tree]
InterPro	IPR002026. Urease_gamma/gamma-beta_su. IPR012010. Urease_gamma_su. [Graphical view]
Gene3D	G3DSA:3.30.280.10. Urease_gamma_reg. 1 hit.
KO	K01430.
Pfam	PF00547. Urease_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF001223. Urease_gamma. 1 hit.
ProDom	PD002319. Urease_gamma_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54111. Urease_gamma_reg. 1 hit.
TIGRFAMs	TIGR00193. Urease_gam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE3_HAEIN

Accession

Primary (citable) accession number: P44393

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program