P44392 (URE2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease subunit beta
EC=3.5.1.5

Alternative name(s):
Urea amidohydrolase subunit beta

Gene names

Name:	ureB
Ordered Locus Names:	HI_0540

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_01954
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01954
Subunit structure	Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01954.
Sequence similarities	Belongs to the urease beta subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Urease subunit beta HAMAP MF_01954		PRO_0000067576

Sequences

	Sequence		Length	Mass (Da)
	P44392 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: DA7919DDA10F6C47	FASTA	101	11,161
	10 20 30 40 50 60 MIPGEYQLAE GDILANVGRK TVKIEVTNSG DRPIQVGSHY HFFETNNALK FDRTLARGMR 70 80 90 100 LNVPSGNAVR FEPGEVKSVE LVAFGGNQII YGFHNQIDGK L

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22198.1.
PIR	I64075.
RefSeq	NP_438698.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44392.
SMR	P44392. Positions 1-101.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950763.
GenomeReviews	Gene locus HI_0540 in contig L42023_GR.
KEGG	hin:HI0540.
PATRIC	20189633. VBIHaeInf48452_0559.
TIGR	HI_0540.
Phylogenomic databases
HOGENOM	HBG365918.
OMA	RIVYGFN.
ProtClustDB	PRK13203.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0540-MONOMER.
Family and domain databases
HAMAP	MF_01954. Urease_beta. [Tree]
InterPro	IPR002019. Urease_beta. [Graphical view]
Gene3D	G3DSA:2.10.150.10. Urease_beta. 1 hit.
KO	K01429.
Pfam	PF00699. Urease_beta. 1 hit. [Graphical view]
SUPFAM	SSF51278. Urease_beta. 1 hit.
TIGRFAMs	TIGR00192. Urease_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE2_HAEIN

Accession

Primary (citable) accession number: P44392

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program