Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urease subunit alpha

Gene

ureC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi143 – 1431Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi224 – 2241Nickel 1; via carbamate groupUniRule annotation
Metal bindingi224 – 2241Nickel 2; via carbamate groupUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation
Metal bindingi253 – 2531Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi279 – 2791Nickel 2; via tele nitrogenUniRule annotation
Active sitei327 – 3271Proton donorUniRule annotation
Metal bindingi367 – 3671Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Protein family/group databases

MEROPSiM38.982.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:HI_0539
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Urease subunit alphaPRO_0000067542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0539.

Structurei

3D structure databases

ProteinModelPortaliP44391.
SMRiP44391. Positions 5-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 572437UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiEOG6ND0GM.
PhylomeDBiP44391.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTISRAQY VATYGPTVGD KVRLGDTNLW ATIEQDLLTK GDECKFGGGK
60 70 80 90 100
SVRDGMAQSG TATRDNPNVL DFVITNVMII DAKLGIIKAD IGIRDGRIVG
110 120 130 140 150
IGQAGNPDTM DNVTPNMIIG ASTEVHNGAH LIATAGGIDT HIHFICPQQA
160 170 180 190 200
QHAIESGVTT LIGGGTGPAD GTHATTCTPG AWYMERMFQA AEALPVNVGF
210 220 230 240 250
FGKGNCSTLD PLREQIEAGA LGLKIHEDWG ATPAVIDSAL KVADEMDIQV
260 270 280 290 300
AIHTDTLNES GFLEDTMKAI DGRVIHTFHT EGAGGGHAPD IIKAAMYSNV
310 320 330 340 350
LPASTNPTRP FTKNTIDEHL DMLMVCHHLD KRVPEDVAFA DSRIRPETIA
360 370 380 390 400
AEDILHDMGV FSIMSSDSQA MGRIGEVVIR TWQTADKMKM QRGELGNEGN
410 420 430 440 450
DNFRIKRYIA KYTINPAIAH GIAEHIGSLE VGKIADIVLW KPMFFGVKPE
460 470 480 490 500
VVIKKGFISY AKMGDPNASI PTPQPVFYRP MYGAQGLATA QTAVFFVSQA
510 520 530 540 550
AEKADIRAKF GLHKETIAVK GCRNVGKKDL VHNDVTPNIT VDAERYEVRV
560 570
DGELITCEPV DSVPLGQRYF LF
Length:572
Mass (Da):61,776
Last modified:November 1, 1995 - v1
Checksum:i5E26396652BB6B43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22197.1.
PIRiH64075.
RefSeqiNP_438697.1. NC_000907.1.
WP_005694142.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22197; AAC22197; HI_0539.
GeneIDi950768.
KEGGihin:HI0539.
PATRICi20189631. VBIHaeInf48452_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22197.1.
PIRiH64075.
RefSeqiNP_438697.1. NC_000907.1.
WP_005694142.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44391.
SMRiP44391. Positions 5-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0539.

Protein family/group databases

MEROPSiM38.982.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22197; AAC22197; HI_0539.
GeneIDi950768.
KEGGihin:HI0539.
PATRICi20189631. VBIHaeInf48452_0558.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiEOG6ND0GM.
PhylomeDBiP44391.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiURE1_HAEIN
AccessioniPrimary (citable) accession number: P44391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.