Reviewed, UniProtKB/Swiss-Prot P44390 (CATA_HAEIN)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:	katA
Synonyms:	hktE
Ordered Locus Names:	HI0928

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group.
Subunit structure	Homohexamer By similarity.
Subcellular location	CytoplasmProbable.
Induction	By hydrogen peroxide.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Catalase		PRO_0000084986
Sites
	Active site	63	1	By similarity
	Active site	136	1	By similarity
	Metal binding	346	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	357	1	N → C in AAA20441. Ref.1
	Sequence conflict	384	1	N → T in AAA20441. Ref.1
	Sequence conflict	413	1	N → S in AAA20441. Ref.1
	Sequence conflict	423	1	N → T in AAA20441. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P44390-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4FAFC16DB44043B0	FASTA	508	57,680
	10 20 30 40 50 60 MSSQCPFSHL AATNLTMGNG APVADNQNSL TAGPRGPLLA QDLWLNEKLA DFVREVIPER 70 80 90 100 110 120 RMHAKGSGAF GTFTVTHDIT KYTRAKIFSE VGKKTEMFAR FTTVAGERGA ADAERDIRGF 130 140 150 160 170 180 ALKFYTEEGN WDLVGNNTPV FFLRDPRKFP DLNKAVKRDP RTNMRSATNN WDFWTLLPEA 190 200 210 220 230 240 LHQVTVVMSD RGIPASYRHM HGFGSHTYSF WNEAGERFWV KFHFRTQQGI KNLTDAEAAE 250 260 270 280 290 300 IIANDRESHQ RDLYEAIERG DFPKWTLFVQ IMPEADAEKV PYHPFDLTKV WSKKDYPLIE 310 320 330 340 350 360 VGEFELNRNP ENFFADVEQS AFAPSNLVPG IGASPDRMLQ ARLFNYADAQ RYRLGVNYRQ 370 380 390 400 410 420 IPVNRPRCPV HSNQRDGQGR VDGNYGSLPH YEPNSFSQWQ QQPDFAEPPL RINGDAAHWD 430 440 450 460 470 480 YRNDDNDYFS QPRALFNLMN AEQKQSLFNN TAAAMGDAPD FIKYRHIRNC HWCDAAYGEG 490 500 VAKALGLTVE DALKARDTDP ALGQGGLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A peroxide/ascorbate-inducible catalase from Haemophilus influenzae is homologous to the Escherichia coli katE gene product." Bishai W.R., Smith H.O., Barcak G.J. J. Bacteriol. 176:2914-2921(1994) [PubMed: 8188593] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U02682 Genomic DNA. Translation: AAA20441.1. L42023 Genomic DNA. Translation: AAC22587.1.
PIR	D64103.
RefSeq	NP_439088.1.
3D structure databases
HSSP	HSSP built from PDB template 1M85 based on UniProtKB P42321.
ModBase	Search...
Genome annotation databases
GeneID	949926.
GenomeReviews	Gene locus HI0928 in contig L42023_GR.
KEGG	hin:HI0928.
NMPDR	fig|71421.1.peg.894.
TIGR	HI0928.
Phylogenomic databases
HOGENOM	P44390.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0928-MON.
Family and domain databases
InterPro	IPR002226. Catalase. IPR011614. Catalase_N. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_HAEIN

Accession

Primary (citable) accession number: P44390

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)