P44340 (HIS5_HAEIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Imidazole glycerol phosphate synthase subunit HisH EC=2.4.2.- Alternative name(s): IGP synthase glutamine amidotransferase subunit IGP synthase subunit HisH ImGP synthase subunit HisH Short name=IGPS subunit HisH | ||||
| Gene names |
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| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | ||||
| Taxonomic identifier | 71421 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR By similarity. HAMAP MF_00278 |
| Catalytic activity | 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. HAMAP MF_00278 |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. HAMAP MF_00278 |
| Subunit structure | Heterodimer of HisH and HisF By similarity. HAMAP MF_00278 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00278. |
| Sequence similarities | Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Cellular component | Cytoplasm |
| Domain | Glutamine amidotransferase |
| Molecular function | Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW histidine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 199 | 199 | Imidazole glycerol phosphate synthase subunit HisH HAMAP MF_00278 | PRO_0000152379 | |||||
Regions | |||||||||
| Domain | 3 – 199 | 197 | Glutamine amidotransferase type-1 | ||||||
Sites | |||||||||
| Active site | 78 | 1 | Nucleophile By similarity | ||||||
| Active site | 178 | 1 | By similarity | ||||||
| Active site | 180 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L42023 Genomic DNA. Translation: AAC22131.1. |
| PIR | G64070. |
| RefSeq | NP_438633.1. NC_000907.1. |
3D structure databases | |
| ProteinModelPortal | P44340. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 949532. |
| GenomeReviews | Gene locus HI_0472 in contig L42023_GR. |
| KEGG | hin:HI0472. |
| NMPDR | fig|71421.1.peg.446. |
| PATRIC | 20189499. VBIHaeInf48452_0492. |
| TIGR | HI_0472. |
Phylogenomic databases | |
| HOGENOM | HBG292341. |
| OMA | YSEEDDI. |
| PhylomeDB | P44340. |
| ProtClustDB | PRK13170. |
Enzyme and pathway databases | |
| BioCyc | HINF71421:HI_0472-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00278. HisH. [Tree] |
| InterPro | IPR017926. GATASE_1. IPR010139. Imidazole-glycPsynth_HisH. [Graphical view] |
| KO | K02501. |
| Pfam | PF00117. GATase. 1 hit. [Graphical view] |
| PIRSF | PIRSF000495. Amidotransf_hisH. 1 hit. |
| TIGRFAMs | TIGR01855. IMP_synth_hisH. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HIS5_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P44340 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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