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P44340 (HIS5_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazole glycerol phosphate synthase subunit HisH

EC=2.4.2.-
Alternative name(s):
IGP synthase glutamine amidotransferase subunit
IGP synthase subunit HisH
ImGP synthase subunit HisH
Short name=IGPS subunit HisH
Gene names
Name:hisH
Ordered Locus Names:HI_0472
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR By similarity. HAMAP-Rule MF_00278

Catalytic activity

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. HAMAP-Rule MF_00278

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. HAMAP-Rule MF_00278

Subunit structure

Heterodimer of HisH and HisF By similarity. HAMAP-Rule MF_00278

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00278.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: HAMAP

histidine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Imidazole glycerol phosphate synthase subunit HisH HAMAP-Rule MF_00278
PRO_0000152379

Regions

Domain3 – 199197Glutamine amidotransferase type-1

Sites

Active site781Nucleophile By similarity
Active site1781 By similarity
Active site1801 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44340 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C79126E93E1B55D9

FASTA19922,048
        10         20         30         40         50         60 
MINITIIDTG CANLSSVKFA FDRLGYNTEI TFDLNKIKSA DKLILPGVGT ANAAMYNLQE 

        70         80         90        100        110        120 
RQLIETIQNL TQPVLGICLG MQLMTEFSEE GNVPTLNLIS GKTNRIPDTG LPLPQMGWNR 

       130        140        150        160        170        180 
VQFVKNCPLF DGIVQNSHFY FVHSYAVSPN EHSVAISNYG VNFSAAIAKE NFYGVQFHPE 

       190 
RSGKNGALLL KNFVEKVPF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22131.1.
PIRG64070.
RefSeqNP_438633.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44340.
ModBaseSearch...

Protein-protein interaction databases

STRING71421.HI0472.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22131; AAC22131; HI_0472.
GeneID949532.
KEGGhin:HI0472.
PATRIC20189499. VBIHaeInf48452_0492.

Phylogenomic databases

eggNOGCOG0118.
KOK02501.
OMAYSEEDDI.
ProtClustDBPRK13170.

Enzyme and pathway databases

UniPathwayUPA00031; UER00010.

Family and domain databases

HAMAPMF_00278. HisH.
InterProIPR017926. GATASE.
IPR010139. Imidazole-glycPsynth_HisH.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
PIRSFPIRSF000495. Amidotransf_hisH. 1 hit.
TIGRFAMsTIGR01855. IMP_synth_hisH. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS5_HAEIN
AccessionPrimary (citable) accession number: P44340
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families