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P44335

- GUAA_HAEIN

UniProt

P44335 - GUAA_HAEIN

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Protein
GMP synthase [glutamine-hydrolyzing]
Gene
guaA, HI_0222
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP By similarity.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Nucleophile By similarity
Active sitei179 – 1791 By similarity
Active sitei181 – 1811 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2397ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
  3. pyrophosphatase activity Source: InterPro

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:guaA
Ordered Locus Names:HI_0222
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]UniRule annotation
PRO_0000140131Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0222.

Structurei

3D structure databases

ProteinModelPortaliP44335.
SMRiP44335. Positions 3-523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 205198Glutamine amidotransferase type-1
Add
BLAST
Domaini206 – 398193GMPS ATP-PPase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0519.
KOiK01951.
OMAiKIYGLQF.
OrthoDBiEOG6JHRJV.
PhylomeDBiP44335.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44335-1 [UniParc]FASTAAdd to Basket

« Hide

MTNIHYHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEQQIREFAP    50
TGIILSGSPE STTEENSPRA PEYVFNAGVP VLGICYGMQT MAMQLGGLTE 100
TSDHREFGYA SVSLENSTAL FANLNDNLTA SEPKLDVWMS HGDKVTRLPE 150
NFKVTGTTLT CPIAAMSDES RRFYGVQFHP EVTHTKKGLE LLTNFVVNIC 200
GCETKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV VALLLHRAIG 250
KNLHCVFVDN GLLRLHEGDQ VMEMFGDKFG LNITRVDAES RFLGELAGVS 300
DPEAKRKIIG KVFVDVFDDE SKKLTNVKWL AQGTIYPDVI ESAASKTGKA 350
HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMINRHP 400
FPGPGLGVRV LGEVKKEYCD LLRRADAIFI EELRNSGWYE KTSQAFSVFL 450
PVKSVGVMGD GRKYDWVISL RAVETIDFMT AHWAHLPYDL LGKVSNRIIN 500
EVNGISRVVY DISGKPPATI EWE 523
Length:523
Mass (Da):58,186
Last modified:November 1, 1995 - v1
Checksum:i6361F38BC20CF154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21891.1.
PIRiI64055.
RefSeqiNP_438394.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21891; AAC21891; HI_0222.
GeneIDi951140.
KEGGihin:HI0222.
PATRICi20188965. VBIHaeInf48452_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21891.1 .
PIRi I64055.
RefSeqi NP_438394.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44335.
SMRi P44335. Positions 3-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21891 ; AAC21891 ; HI_0222 .
GeneIDi 951140.
KEGGi hin:HI0222.
PATRICi 20188965. VBIHaeInf48452_0235.

Phylogenomic databases

eggNOGi COG0519.
KOi K01951.
OMAi KIYGLQF.
OrthoDBi EOG6JHRJV.
PhylomeDBi P44335.

Enzyme and pathway databases

UniPathwayi UPA00189 ; UER00296 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00344. GMP_synthase.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiGUAA_HAEIN
AccessioniPrimary (citable) accession number: P44335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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