Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P44335 (GUAA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]

EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:guaA
Ordered Locus Names:HI_0222
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344

Catalytic activity

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
PRO_0000140131

Regions

Domain8 – 205198Glutamine amidotransferase type-1
Domain206 – 398193GMPS ATP-PPase
Nucleotide binding233 – 2397ATP By similarity

Sites

Active site851Nucleophile By similarity
Active site1791 By similarity
Active site1811 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44335 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6361F38BC20CF154

FASTA52358,186
        10         20         30         40         50         60 
MTNIHYHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEQQIREFAP TGIILSGSPE 

        70         80         90        100        110        120 
STTEENSPRA PEYVFNAGVP VLGICYGMQT MAMQLGGLTE TSDHREFGYA SVSLENSTAL 

       130        140        150        160        170        180 
FANLNDNLTA SEPKLDVWMS HGDKVTRLPE NFKVTGTTLT CPIAAMSDES RRFYGVQFHP 

       190        200        210        220        230        240 
EVTHTKKGLE LLTNFVVNIC GCETKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV 

       250        260        270        280        290        300 
VALLLHRAIG KNLHCVFVDN GLLRLHEGDQ VMEMFGDKFG LNITRVDAES RFLGELAGVS 

       310        320        330        340        350        360 
DPEAKRKIIG KVFVDVFDDE SKKLTNVKWL AQGTIYPDVI ESAASKTGKA HVIKSHHNVG 

       370        380        390        400        410        420 
GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMINRHP FPGPGLGVRV LGEVKKEYCD 

       430        440        450        460        470        480 
LLRRADAIFI EELRNSGWYE KTSQAFSVFL PVKSVGVMGD GRKYDWVISL RAVETIDFMT 

       490        500        510        520 
AHWAHLPYDL LGKVSNRIIN EVNGISRVVY DISGKPPATI EWE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21891.1.
PIRI64055.
RefSeqNP_438394.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44335.
SMRP44335. Positions 3-523.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21891; AAC21891; HI_0222.
GeneID951140.
KEGGhin:HI0222.
PATRIC20188965. VBIHaeInf48452_0235.

Phylogenomic databases

eggNOGCOG0519.
KOK01951.
OMAKIYGLQF.
OrthoDBEOG6JHRJV.
PhylomeDBP44335.

Enzyme and pathway databases

UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52317. SSF52317. 1 hit.
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_HAEIN
AccessionPrimary (citable) accession number: P44335
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names