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P44335

- GUAA_HAEIN

UniProt

P44335 - GUAA_HAEIN

Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of GMP from XMP.By similarity

    Catalytic activityi

    ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851NucleophileBy similarity
    Active sitei179 – 1791By similarity
    Active sitei181 – 1811By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi233 – 2397ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
    3. pyrophosphatase activity Source: InterPro

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00189; UER00296.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
    Alternative name(s):
    GMP synthetase
    Glutamine amidotransferase
    Gene namesi
    Name:guaA
    Ordered Locus Names:HI_0222
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]PRO_0000140131Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0222.

    Structurei

    3D structure databases

    ProteinModelPortaliP44335.
    SMRiP44335. Positions 3-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 205198Glutamine amidotransferase type-1Add
    BLAST
    Domaini206 – 398193GMPS ATP-PPaseAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0519.
    KOiK01951.
    OMAiKIYGLQF.
    OrthoDBiEOG6JHRJV.
    PhylomeDBiP44335.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00344. GMP_synthase.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44335-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNIHYHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEQQIREFAP    50
    TGIILSGSPE STTEENSPRA PEYVFNAGVP VLGICYGMQT MAMQLGGLTE 100
    TSDHREFGYA SVSLENSTAL FANLNDNLTA SEPKLDVWMS HGDKVTRLPE 150
    NFKVTGTTLT CPIAAMSDES RRFYGVQFHP EVTHTKKGLE LLTNFVVNIC 200
    GCETKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV VALLLHRAIG 250
    KNLHCVFVDN GLLRLHEGDQ VMEMFGDKFG LNITRVDAES RFLGELAGVS 300
    DPEAKRKIIG KVFVDVFDDE SKKLTNVKWL AQGTIYPDVI ESAASKTGKA 350
    HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMINRHP 400
    FPGPGLGVRV LGEVKKEYCD LLRRADAIFI EELRNSGWYE KTSQAFSVFL 450
    PVKSVGVMGD GRKYDWVISL RAVETIDFMT AHWAHLPYDL LGKVSNRIIN 500
    EVNGISRVVY DISGKPPATI EWE 523
    Length:523
    Mass (Da):58,186
    Last modified:November 1, 1995 - v1
    Checksum:i6361F38BC20CF154
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21891.1.
    PIRiI64055.
    RefSeqiNP_438394.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21891; AAC21891; HI_0222.
    GeneIDi951140.
    KEGGihin:HI0222.
    PATRICi20188965. VBIHaeInf48452_0235.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21891.1 .
    PIRi I64055.
    RefSeqi NP_438394.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44335.
    SMRi P44335. Positions 3-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21891 ; AAC21891 ; HI_0222 .
    GeneIDi 951140.
    KEGGi hin:HI0222.
    PATRICi 20188965. VBIHaeInf48452_0235.

    Phylogenomic databases

    eggNOGi COG0519.
    KOi K01951.
    OMAi KIYGLQF.
    OrthoDBi EOG6JHRJV.
    PhylomeDBi P44335.

    Enzyme and pathway databases

    UniPathwayi UPA00189 ; UER00296 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00344. GMP_synthase.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiGUAA_HAEIN
    AccessioniPrimary (citable) accession number: P44335
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3