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P44334

- IMDH_HAEIN

UniProt

P44334 - IMDH_HAEIN

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene
guaB, HI_0221
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491NAD By similarity
Metal bindingi301 – 3011Potassium; via carbonyl oxygen By similarity
Metal bindingi303 – 3031Potassium; via carbonyl oxygen By similarity
Binding sitei304 – 3041IMP By similarity
Active sitei306 – 3061Thioimidate intermediate By similarity
Metal bindingi306 – 3061Potassium; via carbonyl oxygen By similarity
Binding sitei416 – 4161IMP By similarity
Metal bindingi470 – 4701Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi471 – 4711Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi472 – 4721Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi249 – 2513NAD By similarity
Nucleotide bindingi299 – 3013NAD By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:HI_0221
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Inosine-5'-monophosphate dehydrogenaseUniRule annotationPRO_0000093697Add
BLAST

Proteomic databases

PRIDEiP44334.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0221.

Structurei

3D structure databases

ProteinModelPortaliP44334.
SMRiP44334. Positions 3-486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 15057CBS 1Add
BLAST
Domaini154 – 21562CBS 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 3413IMP binding By similarity
Regioni362 – 3632IMP binding By similarity
Regioni386 – 3905IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6B62F4.
PhylomeDBiP44334.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44334-1 [UniParc]FASTAAdd to Basket

« Hide

MSLRIKQEAL TFDDVLLVPA HSTVLPNTAN LSTQLTKEIR LNIPMLSAAM    50
DTVTETKLAI SLAQEGGIGF IHKNMTIERQ ADRVRKVKKF ESGIVSEPVT 100
VLPNLTLAEL AEMVKKNGFA GYPVVDGENN LIGIITGRDT RFVKDLSKTV 150
SQVMTKKEDL VTVKEGASRE EILELMHQHR VEKVLVVNDS FKLKGMITVK 200
DFQKAEQKPN ACKDEFGRLR VGAAVGAGAG NEERIDALVK AGVDVLLIDS 250
SHGHSEGVLQ RVRETRAKYP NLPIVAGNVA TAEGAIALAD AGASAVKVGI 300
GPGSICTTRI VTGVGVPQIT AIADAAAALK DRGIPVIADG GIRFSGDIAK 350
AIAAGASCVM VGSMFAGTEE APGEIELYQG RAFKSYRGMG SLGAMAKGSS 400
DRYFQSDNAA DKLVPEGIEG RIPYKGYLKE IIHQQMGGLR SCMGLTGCAT 450
IDELRTKAEF VRISGAGIKE SHVHDVAITK EAPNYRMG 488
Length:488
Mass (Da):51,981
Last modified:November 1, 1995 - v1
Checksum:iB477F22344E4BE8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21890.1.
PIRiH64055.
RefSeqiNP_438392.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21890; AAC21890; HI_0221.
GeneIDi951137.
KEGGihin:HI0221.
PATRICi20188961. VBIHaeInf48452_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21890.1 .
PIRi H64055.
RefSeqi NP_438392.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44334.
SMRi P44334. Positions 3-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0221.

Proteomic databases

PRIDEi P44334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21890 ; AAC21890 ; HI_0221 .
GeneIDi 951137.
KEGGi hin:HI0221.
PATRICi 20188961. VBIHaeInf48452_0233.

Phylogenomic databases

eggNOGi COG0517.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6B62F4.
PhylomeDBi P44334.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiIMDH_HAEIN
AccessioniPrimary (citable) accession number: P44334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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