Reviewed, UniProtKB/Swiss-Prot P44332 (CYSQ_HAEIN)

Names and origin

Protein names

Recommended name:
    3'(2'),5'-bisphosphate nucleotidase cysQ
    EC=3.1.3.7
Alternative name(s):
    3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
    3'-phosphoadenosine 5'-phosphate phosphatase
      Short name=PAP phosphatase
    DPNPase

Gene names

Name:	cysQ
Ordered Locus Names:	HI0559

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) By similarity.
Catalytic activity	Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.
Sequence caution	The sequence AAC22214.1 differs from that shown. Reason: Frameshift at position 5.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'(2'),5'-bisphosphate nucleotidase activity Inferred from electronic annotation. Source: EC inositol or phosphatidylinositol phosphatase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	3'(2'),5'-bisphosphate nucleotidase cysQ		PRO_0000142549
Sites
	Metal binding	69	1	Magnesium 1 By similarity
	Metal binding	89	1	Magnesium 1 By similarity
	Metal binding	89	1	Magnesium 2 By similarity
	Metal binding	91	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	92	1	Magnesium 2 By similarity
	Metal binding	216	1	Magnesium 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P44332-1 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 52DC1BB9E0FD71DC	FASTA	269	30,723
	10 20 30 40 50 60 MLTLNEHLLN QVLLIAYQSG KHLQQFYQKQ VHVELKEDNT PVTEADLFVS QFLTEKLTAL 70 80 90 100 110 120 FPNVPVLSEE NCHISFEERK NWKEYWLIDP LDGTQQFINR TDQFSVLITL VRKNKPVLSV 130 140 150 160 170 180 IHAPILSTTY YAMCDFGTFK KQLDQVKKLT KNTTNFDRPL RIAVGATTSQ EKVRSILPKD 190 200 210 220 230 240 FPCEFVVVGS SSLKSGLVAE GAVDCYVRLG QTGEWDTAGA EVLLGETHGA IFDSHFEPLT 250 260 YNQRETLINP HFVMVGDQSF DWRSIFQFN

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC22214.1. Frameshift.
PIR	F64077.
RefSeq	NP_438716.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	949609.
GenomeReviews	Gene locus HI0559 in contig L42023_GR.
KEGG	hin:HI0559.
NMPDR	fig|71421.1.peg.529.
TIGR	HI0559.
Phylogenomic databases
HOGENOM	P44332.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0559-MON.
Family and domain databases
InterPro	IPR006240. Bisphos_bac. IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01331. bisphos_cysQ. 1 hit.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSQ_HAEIN

Accession

Primary (citable) accession number: P44332

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	September 2, 2008
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)