P44330 (K1PF_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphofructokinase
EC=2.7.1.56

Alternative name(s):
Fructose 1-phosphate kinase

Gene names

Name:	fruK
Ordered Locus Names:	HI_0447

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	1-phosphofructokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	1-phosphofructokinase		PRO_0000080079

Sequences

	Sequence		Length	Mass (Da)
	P44330 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 72FE0D6A1C240A55	FASTA	313	33,522
	10 20 30 40 50 60 MASVVTITLN AAYDLVGRLN RIQLGEVNTV ETLGLFPAGK GINVAKVLKD LGVNVAVGGF 70 80 90 100 110 120 LGKDNSADFE QMFNQHGLED KFHRVDGKTR INVKITETEA DVTDLNFLGY QISPQVWQQF 130 140 150 160 170 180 VTDSLAYCLN YDIVAVCGSL PRGVSPELFA DWLNQLHQAG VKVVLDSSNA ALTAGLKAKP 190 200 210 220 230 240 WLVKPNHREL EAWVGHPLNS LEEIIAAAQQ LKAEGIENVI ISMGAKGSLW INNEGVLKAE 250 260 270 280 290 300 PAQCENVVST VGAGDSMVAG LIYGFEKGLS KTETLAFATA VSAFAVSQSN VGVSDLSLLD 310 PILEKVQITM IEG

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22106.1.
PIR	A64069.
RefSeq	NP_438608.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949542.
GenomeReviews	Gene locus HI_0447 in contig L42023_GR.
KEGG	hin:HI0447.
NMPDR	fig|71421.1.peg.421.
PATRIC	20189449. VBIHaeInf48452_0467.
TIGR	HI_0447.
Phylogenomic databases
HOGENOM	HBG670529.
OMA	SVDYIVH.
ProtClustDB	PRK09513.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0447-MONOMER.
Family and domain databases
InterPro	IPR022463. 1-phosphofructokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. IPR017583. Tagatose/fructose_Pkinase. [Graphical view]
KO	K00882.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PIRSF	PIRSF000535. 1PFK/6PFK/LacC. 1 hit.
TIGRFAMs	TIGR03168. 1-PFK. 1 hit. TIGR03828. PfkB. 1 hit.
PROSITE	PS00583. PFKB_KINASES_1. 1 hit. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

K1PF_HAEIN

Accession

Primary (citable) accession number: P44330

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program