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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateBy similarity1

GO - Molecular functioni

  • aspartate ammonia-lyase activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-547-MONOMER

Protein family/group databases

MoonProtiP44324

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyase (EC:4.3.1.1)
Short name:
Aspartase
Gene namesi
Name:aspA
Ordered Locus Names:HI_0534
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001613411 – 475Aspartate ammonia-lyaseAdd BLAST475

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0534

Structurei

3D structure databases

ProteinModelPortaliP44324
SMRiP44324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 147Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ0 Bacteria
COG1027 LUCA
KOiK01744
OMAiEICENYV
PhylomeDBiP44324

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR004708 ApsA
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00839 aspA, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

P44324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITMTQFRKE VDLLGERDVP AEAYWGIHTL RAVENFNISN VTISDVPEFV
60 70 80 90 100
RGMVMVKKAT ALANGELGAI PSDIAKAIVA ACDEILTTGK CLDQFPSDVY
110 120 130 140 150
QGGAGTSVNM NTNEVVANLA LEKIGHKKGE YNVINPMDHV NASQSTNDAY
160 170 180 190 200
PTGFRIAVYN SILKLIDKIQ YLHDSFDNKA KEFANILKMG RTQLQDAVPM
210 220 230 240 250
TVGQEFKAFA VLLEEEVRNL KRTAGLLLEV NLGATAIGTG LNTPQGYTEL
260 270 280 290 300
VVKHLAEVTG LACVPAENLI EATSDCGAYV MVHGALKRTA VKLSKVCNDL
310 320 330 340 350
RLLSSGPRAG LKEINLPELQ AGSSIMPAKV NPVVPEVVNQ VCFKVIGNDT
360 370 380 390 400
TVTFASEAGQ LQLNVMEPVI GQAMFESIDI LTNACVNLRD KCVDGITVNK
410 420 430 440 450
EICENYVFNS IGIVTYLNPF IGHHNGDLVG KICAQTGKGV REVVLEKGLL
460 470
TEEQLDDILS VENLMNPTYK AKLNK
Length:475
Mass (Da):51,483
Last modified:November 1, 1995 - v1
Checksum:iE89F8041436EB9EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22191.1
PIRiC64075
RefSeqiNP_438692.1, NC_000907.1
WP_010869000.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22191; AAC22191; HI_0534
GeneIDi949597
KEGGihin:HI0534
PATRICifig|71421.8.peg.553

Similar proteinsi

Entry informationi

Entry nameiASPA_HAEIN
AccessioniPrimary (citable) accession number: P44324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health