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P44324 (ASPA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate ammonia-lyase
Short name=Aspartase
EC=4.3.1.1
Gene names
Name:aspA
Ordered Locus Names:HI_0534
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate = fumarate + NH3.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

Ontologies

Keywords
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaspartate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular functionaspartate ammonia-lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475Aspartate ammonia-lyase
PRO_0000161341

Regions

Region145 – 1473Substrate binding By similarity

Sites

Binding site1061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P44324 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E89F8041436EB9EA

FASTA47551,483
        10         20         30         40         50         60 
MITMTQFRKE VDLLGERDVP AEAYWGIHTL RAVENFNISN VTISDVPEFV RGMVMVKKAT 

        70         80         90        100        110        120 
ALANGELGAI PSDIAKAIVA ACDEILTTGK CLDQFPSDVY QGGAGTSVNM NTNEVVANLA 

       130        140        150        160        170        180 
LEKIGHKKGE YNVINPMDHV NASQSTNDAY PTGFRIAVYN SILKLIDKIQ YLHDSFDNKA 

       190        200        210        220        230        240 
KEFANILKMG RTQLQDAVPM TVGQEFKAFA VLLEEEVRNL KRTAGLLLEV NLGATAIGTG 

       250        260        270        280        290        300 
LNTPQGYTEL VVKHLAEVTG LACVPAENLI EATSDCGAYV MVHGALKRTA VKLSKVCNDL 

       310        320        330        340        350        360 
RLLSSGPRAG LKEINLPELQ AGSSIMPAKV NPVVPEVVNQ VCFKVIGNDT TVTFASEAGQ 

       370        380        390        400        410        420 
LQLNVMEPVI GQAMFESIDI LTNACVNLRD KCVDGITVNK EICENYVFNS IGIVTYLNPF 

       430        440        450        460        470 
IGHHNGDLVG KICAQTGKGV REVVLEKGLL TEEQLDDILS VENLMNPTYK AKLNK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22191.1.
PIRC64075.
RefSeqNP_438692.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44324.
SMRP44324. Positions 8-461.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949597.
GenomeReviewsGene locus HI_0534 in contig L42023_GR.
KEGGhin:HI0534.
NMPDRfig|71421.1.peg.505.
PATRIC20189621. VBIHaeInf48452_0553.
TIGRHI_0534.

Phylogenomic databases

HOGENOMHBG284369.
OMAVGKICAQ.
ProtClustDBPRK12273.

Enzyme and pathway databases

BioCycHINF71421:HI_0534-MONOMER.

Family and domain databases

InterProIPR004708. ApsA.
IPR003031. D_crystallin.
IPR018951. Fumarase_C_C.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR024083. L-Aspartase-like_N.
IPR022761. Lyase1_N.
[Graphical view]
Gene3DG3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KOK01744.
PfamPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00839. AspA. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASPA_HAEIN
AccessionPrimary (citable) accession number: P44324
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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