Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P44315

- ASSY_HAEIN

UniProt

P44315 - ASSY_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Argininosuccinate synthase

Gene

argG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei100 – 1001CitrullineBy similarity
Binding sitei130 – 1301ATP; via amide nitrogenBy similarity
Binding sitei132 – 1321AspartateBy similarity
Binding sitei132 – 1321ATPBy similarity
Binding sitei136 – 1361AspartateBy similarity
Binding sitei136 – 1361CitrullineBy similarity
Binding sitei137 – 1371AspartateBy similarity
Binding sitei137 – 1371ATPBy similarity
Binding sitei140 – 1401CitrullineBy similarity
Binding sitei193 – 1931CitrullineBy similarity
Binding sitei195 – 1951ATPBy similarity
Binding sitei202 – 2021CitrullineBy similarity
Binding sitei204 – 2041CitrullineBy similarity
Binding sitei281 – 2811CitrullineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPBy similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:HI_1727
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Argininosuccinate synthasePRO_0000148700Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1727.

Structurei

3D structure databases

ProteinModelPortaliP44315.
SMRiP44315. Positions 4-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiRQEMSEF.
OrthoDBiEOG6K9QCV.
PhylomeDBiP44315.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTILQNLP KGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD
60 70 80 90 100
EDDYNAIPKK AMAYGAENAR LIDCRAQLAH EGIAAIQCGA FHISTGGIPY
110 120 130 140 150
FNTTPLGRAV TGTMLVAAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP
160 170 180 190 200
NLKIYKPWLD VQFIEELGGR LEMSQFLIEN GFDYKMSVEK AYSTDSNMLG
210 220 230 240 250
ATHEAKDLEQ LSTGMKIVKP IMGVAFWDEK VEIKPETVTV TFEDGVPVAL
260 270 280 290 300
NGKHFDNAVD LILEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL
310 320 330 340 350
LHIAYERLVT GIHNEDTIEQ YRINGIRLGR LLYQGRWFDP QALMLRETAQ
360 370 380 390 400
RWVAKAITGT VTLELRRGND FTILNTESPN LTYEAERLSM EKVEDAPFDP
410 420 430 440
IDRIGQLTMR NLDVSDTRGK LGIYAQTGLL SAIKDSVLPQ LGKK
Length:444
Mass (Da):49,289
Last modified:November 1, 1995 - v1
Checksum:iF833EDD718199098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23373.1.
PIRiF64138.
RefSeqiNP_439868.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23373; AAC23373; HI_1727.
GeneIDi950537.
KEGGihin:HI1727.
PATRICi20192207. VBIHaeInf48452_1806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23373.1 .
PIRi F64138.
RefSeqi NP_439868.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44315.
SMRi P44315. Positions 4-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23373 ; AAC23373 ; HI_1727 .
GeneIDi 950537.
KEGGi hin:HI1727.
PATRICi 20192207. VBIHaeInf48452_1806.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi RQEMSEF.
OrthoDBi EOG6K9QCV.
PhylomeDBi P44315.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiASSY_HAEIN
AccessioniPrimary (citable) accession number: P44315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3