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P44315

- ASSY_HAEIN

UniProt

P44315 - ASSY_HAEIN

Protein

Argininosuccinate synthase

Gene

argG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei100 – 1001CitrullineBy similarity
    Binding sitei130 – 1301ATP; via amide nitrogenBy similarity
    Binding sitei132 – 1321AspartateBy similarity
    Binding sitei132 – 1321ATPBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361CitrullineBy similarity
    Binding sitei137 – 1371AspartateBy similarity
    Binding sitei137 – 1371ATPBy similarity
    Binding sitei140 – 1401CitrullineBy similarity
    Binding sitei193 – 1931CitrullineBy similarity
    Binding sitei195 – 1951ATPBy similarity
    Binding sitei202 – 2021CitrullineBy similarity
    Binding sitei204 – 2041CitrullineBy similarity
    Binding sitei281 – 2811CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:HI_1727
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Argininosuccinate synthasePRO_0000148700Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1727.

    Structurei

    3D structure databases

    ProteinModelPortaliP44315.
    SMRiP44315. Positions 4-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.
    PhylomeDBiP44315.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44315-1 [UniParc]FASTAAdd to Basket

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    MSNTILQNLP KGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD    50
    EDDYNAIPKK AMAYGAENAR LIDCRAQLAH EGIAAIQCGA FHISTGGIPY 100
    FNTTPLGRAV TGTMLVAAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP 150
    NLKIYKPWLD VQFIEELGGR LEMSQFLIEN GFDYKMSVEK AYSTDSNMLG 200
    ATHEAKDLEQ LSTGMKIVKP IMGVAFWDEK VEIKPETVTV TFEDGVPVAL 250
    NGKHFDNAVD LILEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL 300
    LHIAYERLVT GIHNEDTIEQ YRINGIRLGR LLYQGRWFDP QALMLRETAQ 350
    RWVAKAITGT VTLELRRGND FTILNTESPN LTYEAERLSM EKVEDAPFDP 400
    IDRIGQLTMR NLDVSDTRGK LGIYAQTGLL SAIKDSVLPQ LGKK 444
    Length:444
    Mass (Da):49,289
    Last modified:November 1, 1995 - v1
    Checksum:iF833EDD718199098
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23373.1.
    PIRiF64138.
    RefSeqiNP_439868.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23373; AAC23373; HI_1727.
    GeneIDi950537.
    KEGGihin:HI1727.
    PATRICi20192207. VBIHaeInf48452_1806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23373.1 .
    PIRi F64138.
    RefSeqi NP_439868.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44315.
    SMRi P44315. Positions 4-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23373 ; AAC23373 ; HI_1727 .
    GeneIDi 950537.
    KEGGi hin:HI1727.
    PATRICi 20192207. VBIHaeInf48452_1806.

    Phylogenomic databases

    eggNOGi COG0137.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.
    PhylomeDBi P44315.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiASSY_HAEIN
    AccessioniPrimary (citable) accession number: P44315
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3