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P44312 (G6PI_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:HI_1576
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAC23219.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180650

Sites

Active site3551Proton donor By similarity
Active site3871 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
P44312 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: F65348C667068F16

FASTA54961,622
        10         20         30         40         50         60 
MKNINPTHTH AWKSLEAHKA ELSNITIQDL FKQEKNRFDD YSLTFNNQIL IDFSKNNINQ 

        70         80         90        100        110        120 
TTLSHLRQLA QECALDSAKE AMFTGEKINR TENRAVLHTA LRNRTNTPVL VDGKDVMPEV 

       130        140        150        160        170        180 
NAVLAKMKDF CQRIISGEWK GYTGKAITDV VNIGIGGSDL GPYMVTEALR PYKNHLNMHF 

       190        200        210        220        230        240 
VSNVDGTHIA ETLKKVNPET TLFLVASKTF TTQETMTNAQ SARDWLLKAA KDESAVAKHF 

       250        260        270        280        290        300 
AALSTNAKDV EKFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSIGFENF EALLNGAHEM 

       310        320        330        340        350        360 
DKHFLSTPIE QNIPTTLALV GLWNTNFLGA QTEAILPYDQ YLHRFAAYFQ QGNMESNGKY 

       370        380        390        400        410        420 
VDRDGNVIKN YQTGPIIWGE PGTNGQHAFY QLIHQGTTLI PCDFIAPAQR HNPLADHHNK 

       430        440        450        460        470        480 
LLSNFFAQTE ALAFGKTKEE VEAEFVKAGK SLDDVKNIVP FKVFTGNKPT NSILVQKITP 

       490        500        510        520        530        540 
FTLGALIAMY EHKIFVQGVI FNIFSFDQWG VELGKQLANR ILPELTDSEK VASHDSSTNG 


LINQFKAWR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23219.1. Different initiation.
PIRF64130.
RefSeqNP_439722.2. NC_000907.1.

3D structure databases

ProteinModelPortalP44312.
SMRP44312. Positions 23-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1576.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23219; AAC23219; HI_1576.
GeneID950436.
KEGGhin:HI1576.
PATRIC20191883. VBIHaeInf48452_1649.

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMALKMHFVS.
OrthoDBEOG64R61J.
ProtClustDBPRK00179.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_HAEIN
AccessionPrimary (citable) accession number: P44312
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: February 19, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names