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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461NADPUniRule annotation
Binding sitei150 – 1501NADPUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Active sitei242 – 2421Proton acceptorUniRule annotation
Binding sitei342 – 3421SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:HI_0558
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenasePRO_0000068122Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0558.

Structurei

3D structure databases

ProteinModelPortaliP44311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.
PhylomeDBiP44311.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTDNNCIVI FGASGDLTHR KLIPALYNLY KIGRLSENFS VLGVARSDLN
60 70 80 90 100
DETFREKMRE ALIHNEETTP ETLDAFCSHL YYQAVNTSDA QDYGKLVPRL
110 120 130 140 150
DDLHDKYQTC GNTFYYMSTP PSLYGVIPEC LAAHGLNTEE YGWKRIIVEK
160 170 180 190 200
PFGYDEKTAQ TLDVQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF
210 220 230 240 250
EPLWNRNFID YVEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV
260 270 280 290 300
AMEPPAIINA NSMRDEVAKV MHSLRPLTSE DMENNLVLGQ YTAAEINGKM
310 320 330 340 350
EKGYLEEKGV PANSRTETYI ALRCEIENWR WAGVPFYVRT GKRLPARVTE
360 370 380 390 400
IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE AISMRFGLKK PGAGFEAKEV
410 420 430 440 450
SMDFRYADLA GAQVLTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL
460 470 480 490
DYKANGGRIH EYEAGTWGPV AADKLIAKQG KVWRKPSGLM KKKV
Length:494
Mass (Da):56,189
Last modified:November 1, 1995 - v1
Checksum:i142F81FFB87FBADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22213.1.
PIRiE64077.
RefSeqiNP_438715.1. NC_000907.1.
WP_005694154.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22213; AAC22213; HI_0558.
GeneIDi949608.
KEGGihin:HI0558.
PATRICi20189671. VBIHaeInf48452_0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22213.1.
PIRiE64077.
RefSeqiNP_438715.1. NC_000907.1.
WP_005694154.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP44311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22213; AAC22213; HI_0558.
GeneIDi949608.
KEGGihin:HI0558.
PATRICi20189671. VBIHaeInf48452_0578.

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.
PhylomeDBiP44311.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiG6PD_HAEIN
AccessioniPrimary (citable) accession number: P44311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.