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P44311

- G6PD_HAEIN

UniProt

P44311 - G6PD_HAEIN

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, HI_0558
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461NADP By similarity
Binding sitei150 – 1501NADP By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei218 – 2181Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Active sitei242 – 2421Proton acceptor By similarity
Binding sitei342 – 3421Substrate By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:HI_0558
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068122Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0558.

Structurei

3D structure databases

ProteinModelPortaliP44311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiWARSLKP.
OrthoDBiEOG61308Z.
PhylomeDBiP44311.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44311-1 [UniParc]FASTAAdd to Basket

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MQTDNNCIVI FGASGDLTHR KLIPALYNLY KIGRLSENFS VLGVARSDLN    50
DETFREKMRE ALIHNEETTP ETLDAFCSHL YYQAVNTSDA QDYGKLVPRL 100
DDLHDKYQTC GNTFYYMSTP PSLYGVIPEC LAAHGLNTEE YGWKRIIVEK 150
PFGYDEKTAQ TLDVQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF 200
EPLWNRNFID YVEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV 250
AMEPPAIINA NSMRDEVAKV MHSLRPLTSE DMENNLVLGQ YTAAEINGKM 300
EKGYLEEKGV PANSRTETYI ALRCEIENWR WAGVPFYVRT GKRLPARVTE 350
IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE AISMRFGLKK PGAGFEAKEV 400
SMDFRYADLA GAQVLTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL 450
DYKANGGRIH EYEAGTWGPV AADKLIAKQG KVWRKPSGLM KKKV 494
Length:494
Mass (Da):56,189
Last modified:November 1, 1995 - v1
Checksum:i142F81FFB87FBADF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22213.1.
PIRiE64077.
RefSeqiNP_438715.1. NC_000907.1.
WP_005694154.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22213; AAC22213; HI_0558.
GeneIDi949608.
KEGGihin:HI0558.
PATRICi20189671. VBIHaeInf48452_0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22213.1 .
PIRi E64077.
RefSeqi NP_438715.1. NC_000907.1.
WP_005694154.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0558.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22213 ; AAC22213 ; HI_0558 .
GeneIDi 949608.
KEGGi hin:HI0558.
PATRICi 20189671. VBIHaeInf48452_0578.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi WARSLKP.
OrthoDBi EOG61308Z.
PhylomeDBi P44311.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiG6PD_HAEIN
AccessioniPrimary (citable) accession number: P44311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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