Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P44311

- G6PD_HAEIN

UniProt

P44311 - G6PD_HAEIN

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461NADPUniRule annotation
    Binding sitei150 – 1501NADPUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation
    Active sitei242 – 2421Proton acceptorUniRule annotation
    Binding sitei342 – 3421SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:HI_0558
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenasePRO_0000068122Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0558.

    Structurei

    3D structure databases

    ProteinModelPortaliP44311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiWARSLKP.
    OrthoDBiEOG61308Z.
    PhylomeDBiP44311.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTDNNCIVI FGASGDLTHR KLIPALYNLY KIGRLSENFS VLGVARSDLN    50
    DETFREKMRE ALIHNEETTP ETLDAFCSHL YYQAVNTSDA QDYGKLVPRL 100
    DDLHDKYQTC GNTFYYMSTP PSLYGVIPEC LAAHGLNTEE YGWKRIIVEK 150
    PFGYDEKTAQ TLDVQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF 200
    EPLWNRNFID YVEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV 250
    AMEPPAIINA NSMRDEVAKV MHSLRPLTSE DMENNLVLGQ YTAAEINGKM 300
    EKGYLEEKGV PANSRTETYI ALRCEIENWR WAGVPFYVRT GKRLPARVTE 350
    IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE AISMRFGLKK PGAGFEAKEV 400
    SMDFRYADLA GAQVLTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL 450
    DYKANGGRIH EYEAGTWGPV AADKLIAKQG KVWRKPSGLM KKKV 494
    Length:494
    Mass (Da):56,189
    Last modified:November 1, 1995 - v1
    Checksum:i142F81FFB87FBADF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22213.1.
    PIRiE64077.
    RefSeqiNP_438715.1. NC_000907.1.
    WP_005694154.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22213; AAC22213; HI_0558.
    GeneIDi949608.
    KEGGihin:HI0558.
    PATRICi20189671. VBIHaeInf48452_0578.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22213.1 .
    PIRi E64077.
    RefSeqi NP_438715.1. NC_000907.1.
    WP_005694154.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0558.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22213 ; AAC22213 ; HI_0558 .
    GeneIDi 949608.
    KEGGi hin:HI0558.
    PATRICi 20189671. VBIHaeInf48452_0578.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi WARSLKP.
    OrthoDBi EOG61308Z.
    PhylomeDBi P44311.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiG6PD_HAEIN
    AccessioniPrimary (citable) accession number: P44311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3