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Protein

Guanylate kinase

Gene

gmk

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1766-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:HI_1743
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705451 – 208Guanylate kinaseAdd BLAST208

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1743.

Structurei

3D structure databases

ProteinModelPortaliP44310.
SMRiP44310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 185Guanylate kinase-likeAdd BLAST182

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAGNYYGT.
PhylomeDBiP44310.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P44310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGNLYILS APSGAGKSSL ISALLASDSS TQKMVSVSHT TRAPRPGEVE
60 70 80 90 100
GVHYYFVSKE EFESLIEQDL FLEYAKVFGG NYYGTSLPAI EENLAKGIDV
110 120 130 140 150
FLDIDWQGAQ QIRKKVPSVK SIFILPPSLP ELERRLIGRG QDSEEVIAER
160 170 180 190 200
MSKAMSEISH YDEYDYVIVN DDFEKTLKDL QSILQSERLT KDYQQKQNAM

LIQQLLAK
Length:208
Mass (Da):23,419
Last modified:November 1, 1995 - v1
Checksum:i82E3F92253B96E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23390.1.
PIRiH64139.
RefSeqiNP_439887.1. NC_000907.1.
WP_005693898.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23390; AAC23390; HI_1743.
GeneIDi950885.
KEGGihin:HI1743.
PATRICifig|71421.8.peg.1826.

Similar proteinsi

Entry informationi

Entry nameiKGUA_HAEIN
AccessioniPrimary (citable) accession number: P44310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome