Reviewed, UniProtKB/Swiss-Prot P44303 (AROG_HAEIN)

Names and origin

Protein names

Recommended name:
    Phospho-2-dehydro-3-deoxyheptonate aldolase
    EC=2.5.1.54
Alternative name(s):
    Phospho-2-keto-3-deoxyheptonate aldolase
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
    DAHP synthetase

Gene names

Name:	aroG
Ordered Locus Names:	HI1547

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthetase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Phospho-2-dehydro-3-deoxyheptonate aldolase		PRO_0000140830

Sequences

	Sequence		Length	Mass (Da)
	P44303-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 533B76F7B379CD2D	FASTA	362	39,937
	10 20 30 40 50 60 MAKEKIEIVV ANDDTRIEKV DQVLPPIALL EKYPASEQAA ALVKQTRHEA HNIIHGKDDR 70 80 90 100 110 120 LLVVIGPCSI HDPKAAIEYA TRLKPLREKY KDSLEIIMRV YFEKPRTTVG WKGLINEPYL 130 140 150 160 170 180 NDTYRLNDGL RIARKLLSDI NDLGVPAAGE FLDMITPQYL ADFMSWGAIG ARTTESQVHR 190 200 210 220 230 240 ELASGLSCAV GFKNATNGGV KVALDAIGAA EAPHYFLSVT KFGHSAIVST KGNEDCHIIL 250 260 270 280 290 300 RGGDKGPNYS AEDVEKVCAD IEKTGRIPHV MVDFSHANSS KQYKKQMDVC QDVCNQIAFG 310 320 330 340 350 360 SKQIFGVMVE SHLVEGRQDL VDGKAQTYGQ SITDACIGWE DSERLLQQLS DAVIARRKAT SN

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC23197.1.
PIR	I64128.
RefSeq	NP_439696.1.
3D structure databases
HSSP	HSSP built from PDB template 1GG1 based on UniProtKB P00886.
SMR	P44303. Positions 16-357.
ModBase	Search...
Genome annotation databases
GeneID	950411.
GenomeReviews	Gene locus HI1547 in contig L42023_GR.
KEGG	hin:HI1547.
NMPDR	fig|71421.1.peg.1474.
TIGR	HI1547.
Phylogenomic databases
HOGENOM	P44303.
OMA	MDNSFKL.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1547-MON.
BRENDA	2.5.1.54. 109.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROG_HAEIN

Accession

Primary (citable) accession number: P44303

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)