P44252 (LOLC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein-releasing system transmembrane protein LolC

Gene names

Name:	lolC
Ordered Locus Names:	HI_1555

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipoprotein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Lipoprotein-releasing system transmembrane protein LolC		PRO_0000201813
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	262 – 282	21	Helical; Potential
	Transmembrane	314 – 334	21	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P44252 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7ABEC4E335D57F34	FASTA	393	43,579
	10 20 30 40 50 60 MNFPISLYIA LRYWRAKSAD RFGRLVTNLA SLGIVLGVMA LIIVLSVMNG LEGYQKQQVL 70 80 90 100 110 120 SSIPHAIVSE EQPISTEKTL ENLPHFVQKA VPINTTNVIY QTAKGVSAGQ IIGIQSFSDD 130 140 150 160 170 180 PLVESFDQTK FNEILPRGEF KLVIGDQLAQ KLGVNIGDKI RLMITENSQY TPFGRVPMQR 190 200 210 220 230 240 LFTVSDIYYG YGEASGYEAF ANITDIGRLM RIQPQQAQGY RLFLNDPFQI TELPQHFPTQ 250 260 270 280 290 300 KITDWRVQKG EFFQAVRMEK NMMGLLISLI IVVAISNIVT SLSLMVVDKQ GEIAILQTQG 310 320 330 340 350 360 LTKSQVRSVF IYQGLLVGFV GTLLGAILGV LATLNLTDIV SAVNPQGVFL PTELSFVQMI 370 380 390 FVIGFSLLLS LLSTLYPAYR AAKVEPAAAL RYE

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23204.1.
PIR	A64036.
RefSeq	NP_439704.1. NC_000907.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1555.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC23204; AAC23204; HI_1555.
GeneID	949639.
KEGG	hin:HI1555.
PATRIC	20191835. VBIHaeInf48452_1626.
Phylogenomic databases
eggNOG	COG4591.
KO	K09808.
OMA	ADIGRLM.
ProtClustDB	CLSK870158.
Family and domain databases
InterPro	IPR011925. LolCE_TM. IPR025857. MacB_PCD. IPR003838. Permease_FtsX-like. [Graphical view]
Pfam	PF02687. FtsX. 1 hit. PF12704. MacB_PCD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02212. lolCE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LOLC_HAEIN

Accession

Primary (citable) accession number: P44252

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program