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Protein

Phosphatidylglycerophosphatase A

Gene

pgpA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).By similarity

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

Cofactori

Mg2+By similarity

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA)
  2. Phosphatidylglycerophosphatase B (pgpB), Phosphatidylglycerophosphatase A (pgpA)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1331-MONOMER
UniPathwayiUPA00084; UER00504

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase A (EC:3.1.3.27)
Alternative name(s):
Phosphatidylglycerolphosphate phosphatase A
Short name:
PGP phosphatase A
Gene namesi
Name:pgpA
Ordered Locus Names:HI_1306
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 28HelicalSequence analysisAdd BLAST19
Transmembranei35 – 51HelicalSequence analysisAdd BLAST17
Transmembranei92 – 116HelicalSequence analysisAdd BLAST25
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583601 – 163Phosphatidylglycerophosphatase AAdd BLAST163

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1306

Structurei

3D structure databases

ProteinModelPortaliP44157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZAI Bacteria
COG1267 LUCA
KOiK01095
OMAiPKAPGTF
PhylomeDBiP44157

Family and domain databases

CDDicd06971 PgpA, 1 hit
InterProiView protein in InterPro
IPR026037 PgpA
IPR036681 PgpA-like_sf
IPR007686 YutG/PgpA
PANTHERiPTHR36305 PTHR36305, 1 hit
PfamiView protein in Pfam
PF04608 PgpA, 1 hit
PIRSFiPIRSF006162 PgpA, 1 hit
SUPFAMiSSF101307 SSF101307, 1 hit

Sequencei

Sequence statusi: Complete.

P44157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENNPLKKI SLLNPIHLLA VGFGSGLIHP APGTWGSLAG TILGVILLSL
60 70 80 90 100
LGVKIFLIFT ALCFLLGCYL CQKTTADMGV HDHGSIVWDE FVGVFIVLAA
110 120 130 140 150
IPSLSWQWIL AAFALFRFFD ILKPFPIRYF DEKLENGFGI MIDDVLAAIY
160
AVIVVFAIQY WML
Length:163
Mass (Da):18,035
Last modified:November 1, 1995 - v1
Checksum:i77CC4D4FC550937B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22953.1
PIRiD64025
RefSeqiNP_439457.1, NC_000907.1
WP_005694464.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22953; AAC22953; HI_1306
GeneIDi950237
KEGGihin:HI1306
PATRICifig|71421.8.peg.1358

Similar proteinsi

Entry informationi

Entry nameiPGPA_HAEIN
AccessioniPrimary (citable) accession number: P44157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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