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Protein

tRNA(Met) cytidine acetyltransferase TmcA

Gene

tmcA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Catalyzes the formation of N4-acetylcytidine (ac4C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).UniRule annotation

Caution

Could be the product of a pseudogene. Three frameshifts produce three separate ORFs.Curated

Catalytic activityi

(Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA + H2O = (elongator tRNA(Met))-N4-acetylcytidine(34) + ADP + phosphate + CoA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145ATPUniRule annotation1
Binding sitei291ATPUniRule annotation1
Binding sitei510Acetyl-CoAUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 176ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Met) cytidine acetyltransferase TmcAUniRule annotation (EC:2.3.1.193UniRule annotation)
Gene namesi
Name:tmcAUniRule annotation
Ordered Locus Names:HI_1254/HI_1255/HI_1256
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000138911 – 656tRNA(Met) cytidine acetyltransferase TmcAAdd BLAST656

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1254

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini368 – 542N-acetyltransferaseUniRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni474 – 476Acetyl-CoA bindingUniRule annotation3
Regioni481 – 487Acetyl-CoA bindingUniRule annotation7

Sequence similaritiesi

Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1444 LUCA

Family and domain databases

Gene3Di1.20.120.890, 1 hit
HAMAPiMF_01886 tRNA_acetyltr_TmcA, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR007807 Helicase_dom
IPR027417 P-loop_NTPase
IPR032672 TmcA/NAT10/Kre33
IPR038321 TmcA_C_sf
IPR013562 TmcA_N
IPR033442 TmcA_tRNA_bind
IPR024914 tRNA_acetyltr_TmcA
PANTHERiPTHR10925 PTHR10925, 1 hit
PTHR10925:SF6 PTHR10925:SF6, 1 hit
PfamiView protein in Pfam
PF08351 DUF1726, 1 hit
PF13718 GNAT_acetyltr_2, 2 hits
PF05127 Helicase_RecD, 1 hit
PF17176 tRNA_bind_3, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

P44140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRQLQILI RKTLPLVPDH VLIIGESGIA FSKATNLLGQ EFEHILFDGR
60 70 80 90 100
NGIHLEALAI AAGTLKMGGT LCLVLSDWEN LSQQPDQDSL RWNGNQSAIA
110 120 130 140 150
TPNFIYHFKQ CIERYHFPIL REESAVEFPT VFYSNEHHKN ATLAQQQIIE
160 170 180 190 200
NILQAEQDIY FLTAKRGRGK SALLGMLANQ IQAPVYLTAP NKSAVHSVIE
210 220 230 240 250
FSEGDIEFIA PDELALTLQT EPEFSQSAWL LVDEAAMIPL PLLQEYSRYF
260 270 280 290 300
QHIVFSTTIH SYEGTGRGFE LKFKRKIHRT FQHFELKQPL RWQENDPLEH
310 320 330 340 350
FIDDLLLLNA EDDFQHFDYS NITYNIEENA KNLSFPCLRG KVPEGPKGDL
360 370 380 390 400
DIASLPQALE ALLTSKGSEG KYNRQFFFRD FYGLMTIAHY RTSPLDLRRL
410 420 430 440 450
LDGKNQRFYF AEYQQNLLGA IWALEEGNMA DDELIIQIQQ GKRRPKGNLV
460 470 480 490 500
PQALCFHENL SQACKLRSLR ISRIAVQPNW QQKGIGQNLM QAMENADVDF
510 520 530 540 550
LSVSFGYTDE LAKFWQKCGF VLVHLGEHQE ASSGCYSAIA LKGISKEGLA
560 570 580 590 600
LVDTAYKQFQ RNLPLSFHPF AINFEQNQLD WQLDDFDWMS LKNFANFHRT
610 620 630 640 650
LFSSIPAMRR LLKLAGKENF PLISAYLTKK QFPINKKKGV ECLRLEIKQY

LERGTL
Length:656
Mass (Da):75,162
Last modified:January 11, 2011 - v2
Checksum:i9975F7685CB45303
GO

Sequence cautioni

The sequence AAC22904 differs from that shown. Reason: Frameshift at positions 349, 389 and 502.Curated
The sequence AAC22910 differs from that shown. Reason: Frameshift at positions 349, 389 and 502.Curated
The sequence AAC22911 differs from that shown. Reason: Frameshift at positions 349, 389 and 502.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22904.1 Frameshift.
L42023 Genomic DNA Translation: AAC22910.1 Frameshift.
L42023 Genomic DNA Translation: AAC22911.1 Frameshift.
PIRiE64023
F64023
G64023

Genome annotation databases

EnsemblBacteriaiAAC22904; AAC22904; HI_1254
AAC22910; AAC22910; HI_1255
AAC22911; AAC22911; HI_1256

Similar proteinsi

Entry informationi

Entry nameiTMCA_HAEIN
AccessioniPrimary (citable) accession number: P44140
Secondary accession number(s): P44141, P44142
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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