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P44049 (MLTC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Membrane-bound lytic murein transglycosylase C

EC=4.2.2.n1
Alternative name(s):
Murein lyase C
Gene names
Name:mltC
Ordered Locus Names:HI_0761
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division By similarity. HAMAP-Rule MF_01616

Catalytic activity

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. HAMAP-Rule MF_01616

Subcellular location

Cell outer membrane; Lipid-anchor By similarity HAMAP-Rule MF_01616.

Sequence similarities

Belongs to the transglycosylase Slt family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 357342Membrane-bound lytic murein transglycosylase C HAMAP-Rule MF_01616
PRO_0000032790

Amino acid modifications

Lipidation161N-palmitoyl cysteine Potential
Lipidation161S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
P44049 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 277DCF968E7248DD

FASTA35740,207
        10         20         30         40         50         60 
MKKYLLLALL PFLYACSNSS NQGINYDEAF AKDTQGLDIL TGQFSHNIDR IWGVNELLVA 

        70         80         90        100        110        120 
SRKDYVKYTD SFYTRSHVSF DEGNIVIETQ QDLNRLHNAI VHTLLMGADA KGIDLFASGD 

       130        140        150        160        170        180 
VPISSRPFLL GQVVDHQGQH IANQVIASNF ATYLIQNKLQ TRRLQNGHTV QFVSVPMIAN 

       190        200        210        220        230        240 
HVEVRARKYL PLIRKAAQRY GIDESLILGI MQTESSFNPY AISYANAIGL MQVVPHTAGR 

       250        260        270        280        290        300 
DVFAMKGKGG QPSTRYLYDP ANNIDAGVSY LWILQNQYLD GITNPTSKRF AMISAYNSGA 

       310        320        330        340        350 
GAVLRVFDND KDTAIYKINQ MYPEQVYRIL TTVHPSSQAR NYLLKVDKAQ KKFRVRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22420.1.
PIRD64013.
RefSeqNP_438920.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44049.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22420; AAC22420; HI_0761.
GeneID950821.
KEGGhin:HI0761.
PATRIC20190169. VBIHaeInf48452_0800.

Phylogenomic databases

eggNOGCOG0741.
KOK08306.
OMASDANDIQ.
OrthoDBEOG6Z0Q66.
ProtClustDBPRK11671.

Family and domain databases

HAMAPMF_01616. MltC.
InterProIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR008258. TGlycosylase-like_SLT.
IPR000189. Transglyc_AS.
[Graphical view]
PfamPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMLTC_HAEIN
AccessionPrimary (citable) accession number: P44049
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names