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P44049

- MLTC_HAEIN

UniProt

P44049 - MLTC_HAEIN

Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

    Catalytic activityi

    Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

    GO - Molecular functioni

    1. carbon-oxygen lyase activity, acting on polysaccharides Source: UniProtKB-EC
    2. hydrolase activity, acting on glycosyl bonds Source: InterPro
    3. lytic transglycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
    Alternative name(s):
    Murein lyase CUniRule annotation
    Gene namesi
    Name:mltCUniRule annotation
    Ordered Locus Names:HI_0761
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515UniRule annotationAdd
    BLAST
    Chaini16 – 357342Membrane-bound lytic murein transglycosylase CPRO_0000032790Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi16 – 161N-palmitoyl cysteineUniRule annotation
    Lipidationi16 – 161S-diacylglycerol cysteineUniRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0761.

    Structurei

    3D structure databases

    ProteinModelPortaliP44049.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transglycosylase Slt family.UniRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0741.
    KOiK08306.
    OMAiDVFKMKG.
    OrthoDBiEOG6Z0Q66.
    PhylomeDBiP44049.

    Family and domain databases

    HAMAPiMF_01616. MltC.
    InterProiIPR023346. Lysozyme-like_dom.
    IPR023664. Murein_transglycosylaseC.
    IPR024570. Murein_transglycosylaseC_N.
    IPR008258. TGlycosylase-like_SLT.
    IPR000189. Transglyc_AS.
    [Graphical view]
    PfamiPF11873. DUF3393. 1 hit.
    PF01464. SLT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    PS00922. TRANSGLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P44049-1 [UniParc]FASTAAdd to Basket

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    MKKYLLLALL PFLYACSNSS NQGINYDEAF AKDTQGLDIL TGQFSHNIDR    50
    IWGVNELLVA SRKDYVKYTD SFYTRSHVSF DEGNIVIETQ QDLNRLHNAI 100
    VHTLLMGADA KGIDLFASGD VPISSRPFLL GQVVDHQGQH IANQVIASNF 150
    ATYLIQNKLQ TRRLQNGHTV QFVSVPMIAN HVEVRARKYL PLIRKAAQRY 200
    GIDESLILGI MQTESSFNPY AISYANAIGL MQVVPHTAGR DVFAMKGKGG 250
    QPSTRYLYDP ANNIDAGVSY LWILQNQYLD GITNPTSKRF AMISAYNSGA 300
    GAVLRVFDND KDTAIYKINQ MYPEQVYRIL TTVHPSSQAR NYLLKVDKAQ 350
    KKFRVRR 357
    Length:357
    Mass (Da):40,207
    Last modified:November 1, 1995 - v1
    Checksum:i277DCF968E7248DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22420.1.
    PIRiD64013.
    RefSeqiNP_438920.1. NC_000907.1.
    WP_005693158.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22420; AAC22420; HI_0761.
    GeneIDi950821.
    KEGGihin:HI0761.
    PATRICi20190169. VBIHaeInf48452_0800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22420.1 .
    PIRi D64013.
    RefSeqi NP_438920.1. NC_000907.1.
    WP_005693158.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44049.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22420 ; AAC22420 ; HI_0761 .
    GeneIDi 950821.
    KEGGi hin:HI0761.
    PATRICi 20190169. VBIHaeInf48452_0800.

    Phylogenomic databases

    eggNOGi COG0741.
    KOi K08306.
    OMAi DVFKMKG.
    OrthoDBi EOG6Z0Q66.
    PhylomeDBi P44049.

    Family and domain databases

    HAMAPi MF_01616. MltC.
    InterProi IPR023346. Lysozyme-like_dom.
    IPR023664. Murein_transglycosylaseC.
    IPR024570. Murein_transglycosylaseC_N.
    IPR008258. TGlycosylase-like_SLT.
    IPR000189. Transglyc_AS.
    [Graphical view ]
    Pfami PF11873. DUF3393. 1 hit.
    PF01464. SLT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    PS00922. TRANSGLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMLTC_HAEIN
    AccessioniPrimary (citable) accession number: P44049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3