P44049 (MLTC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-bound lytic murein transglycosylase C
EC=4.2.2.n1

Alternative name(s):
Murein lyase C

Gene names

Name:	mltC
Ordered Locus Names:	HI_0761

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division By similarity. HAMAP-Rule MF_01616
Catalytic activity	Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. HAMAP-Rule MF_01616
Subcellular location	Cell outer membrane; Lipid-anchor By similarity HAMAP-Rule MF_01616.
Sequence similarities	Belongs to the transglycosylase Slt family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
Molecular function	Lyase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: HAMAP peptidoglycan metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carbon-oxygen lyase activity, acting on polysaccharides Inferred from electronic annotation. Source: EC hydrolase activity, acting on glycosyl bonds Inferred from electronic annotation. Source: InterPro lytic transglycosylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 357	342	Membrane-bound lytic murein transglycosylase C HAMAP-Rule MF_01616		PRO_0000032790
Amino acid modifications
	Lipidation	16	1	N-palmitoyl cysteine Potential
	Lipidation	16	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P44049 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 277DCF968E7248DD	FASTA	357	40,207
	10 20 30 40 50 60 MKKYLLLALL PFLYACSNSS NQGINYDEAF AKDTQGLDIL TGQFSHNIDR IWGVNELLVA 70 80 90 100 110 120 SRKDYVKYTD SFYTRSHVSF DEGNIVIETQ QDLNRLHNAI VHTLLMGADA KGIDLFASGD 130 140 150 160 170 180 VPISSRPFLL GQVVDHQGQH IANQVIASNF ATYLIQNKLQ TRRLQNGHTV QFVSVPMIAN 190 200 210 220 230 240 HVEVRARKYL PLIRKAAQRY GIDESLILGI MQTESSFNPY AISYANAIGL MQVVPHTAGR 250 260 270 280 290 300 DVFAMKGKGG QPSTRYLYDP ANNIDAGVSY LWILQNQYLD GITNPTSKRF AMISAYNSGA 310 320 330 340 350 GAVLRVFDND KDTAIYKINQ MYPEQVYRIL TTVHPSSQAR NYLLKVDKAQ KKFRVRR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22420.1.
PIR	D64013.
RefSeq	NP_438920.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P44049.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22420; AAC22420; HI_0761.
GeneID	950821.
KEGG	hin:HI0761.
PATRIC	20190169. VBIHaeInf48452_0800.
Phylogenomic databases
eggNOG	COG0741.
KO	K08306.
OMA	DVFKMKG.
ProtClustDB	PRK11671.
Family and domain databases
HAMAP	MF_01616. MltC.
InterPro	IPR023346. Lysozyme-like_dom. IPR008258. Lytic_TGlycosylase-like_cat. IPR023664. Murein_transglycosylaseC. IPR024570. Murein_transglycosylaseC_N. IPR000189. Transglyc_AS. [Graphical view]
Pfam	PF11873. DUF3393. 1 hit. PF01464. SLT. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. PS00922. TRANSGLYCOSYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MLTC_HAEIN

Accession

Primary (citable) accession number: P44049

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program