Reviewed,
UniProtKB/Swiss-Prot P44009 (APHA_HAEIN)
Last modified
June 16, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Class B acid phosphatase EC=3.1.3.2 | ||||||
| Gene names |
| ||||||
| Organism | Haemophilus influenzae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 727 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 236 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Periplasm Potential. |
| Sequence similarities | Belongs to the class B bacterial acid phosphatase family. |
| Sequence caution | The sequence AAC22152.1 differs from that shown. Reason: Frameshift at position 66. Produces two separate ORFs. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Periplasm |
| Domain | Signal |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro |
| Molecular function | acid phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 236 | 214 | Class B acid phosphatase | PRO_0000024005 | |||||
Sites | |||||||||
| Metal binding | 67 | 1 | Magnesium By similarity | ||||||
| Metal binding | 69 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 191 | 1 | Magnesium By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 73 | 1 | Missing in CAA68889. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
| [2] | Rossolini G.M., Bonci A., Schippa S., Iori P., Thaller M.C. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CCUG 7317/A. |
| [3] | "Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed: 10675023] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| L42023 Genomic DNA. Translation: AAC22151.1. Frameshift. L42023 Genomic DNA. Translation: AAC22152.1. Frameshift. Y07615 Genomic DNA. Translation: CAA68889.1. | |
| PIR | T09434. |
| RefSeq | NP_438653.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 950561. |
| TIGR | HI0494. HI0495. |
Phylogenomic databases | |
| HOGENOM | P44009. |
Enzyme and pathway databases | |
| BioCyc | HINF71421:HI_0494-MON. HINF71421:HI_0495-MON. |
| BRENDA | 3.1.3.2. 109. |
Family and domain databases | |
| InterPro | IPR005519. Acid_phosphat_B. IPR010025. HAD-SF_ppase_IIIB_AphA. [Graphical view] |
| Pfam | PF03767. Acid_phosphat_B. 1 hit. [Graphical view] |
| PIRSF | PIRSF017818. Acid_Ptase_B. 1 hit. |
| TIGRFAMs | TIGR01672. AphA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | APHA_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P44009 Secondary accession number(s): P44730, P77869 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


