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P44001

- HISX_HAEIN

UniProt

P44001 - HISX_HAEIN

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Protein
Histidinol dehydrogenase
Gene
hisD, HI_0469
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei232 – 2321Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi257 – 2571Zinc By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Active sitei322 – 3221Proton acceptor By similarity
Binding sitei322 – 3221Substrate By similarity
Metal bindingi355 – 3551Zinc By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei409 – 4091Substrate By similarity
Metal bindingi414 – 4141Zinc By similarity
Binding sitei414 – 4141Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:HI_0469
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenaseUniRule annotation
PRO_0000135777Add
BLAST

Proteomic databases

PRIDEiP44001.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0469.

Structurei

3D structure databases

ProteinModelPortaliP44001.
SMRiP44001. Positions 4-425.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.
PhylomeDBiP44001.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44001-1 [UniParc]FASTAAdd to Basket

« Hide

MQTIIWNHLS ETEKRKVIMR PVQQNGKNIQ QAVNAIRENV AYNGDRALFE    50
LCEKFDGVKL DKLIVSADEI QAASSRISVK LRNAIEQAKT NIEAFHKAQQ 100
NQEIDLEIQE GVRCQVVTRP ISCVGLYIPG GSAPLFSTVL MLAIPAKIAG 150
CKKIVLCSPP PISDEILYTA HLCGVETIYA IGGAQAVFAM AQGTESVAKV 200
DKIFGPGNAF VTEAKRQVAQ NSTAIDMPAG PSEVLVIADE SADPEFVASD 250
LLSQAEHGAD SQVILVATCE TLAKETALAI ERQLALLPRA ETVRKALNHS 300
RIFIAESLEQ AVEISNEYAP EHLIVQTKNA RKLLPYLDNA GSIFLGAYSP 350
ESMGDYASGT NHVLPTYGYT KTYSSLGLAD FSKRMTVQEL TPKGFKNLAE 400
TVEVMAEAEQ LAAHKMAVSV RLAKLNI 427
Length:427
Mass (Da):46,339
Last modified:November 1, 1995 - v1
Checksum:iFC5C5D8675654462
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22128.1.
PIRiA64008.
RefSeqiNP_438630.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22128; AAC22128; HI_0469.
GeneIDi949557.
KEGGihin:HI0469.
PATRICi20189493. VBIHaeInf48452_0489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22128.1 .
PIRi A64008.
RefSeqi NP_438630.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44001.
SMRi P44001. Positions 4-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0469.

Proteomic databases

PRIDEi P44001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22128 ; AAC22128 ; HI_0469 .
GeneIDi 949557.
KEGGi hin:HI0469.
PATRICi 20189493. VBIHaeInf48452_0489.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.
PhylomeDBi P44001.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiHISX_HAEIN
AccessioniPrimary (citable) accession number: P44001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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