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P44001 (HISX_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase
Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:HI_0469
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Histidinol dehydrogenase HAMAP MF_01024
PRO_0000135777

Sites

Active site3211Proton acceptor By similarity
Active site3221Proton acceptor By similarity
Metal binding2541Zinc By similarity
Metal binding2571Zinc By similarity
Metal binding3551Zinc By similarity
Metal binding4141Zinc By similarity
Binding site1271NAD By similarity
Binding site1851NAD By similarity
Binding site2081NAD By similarity
Binding site2321Substrate By similarity
Binding site2541Substrate By similarity
Binding site2571Substrate By similarity
Binding site3221Substrate By similarity
Binding site3551Substrate By similarity
Binding site4091Substrate By similarity
Binding site4141Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P44001 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: FC5C5D8675654462

FASTA42746,339
        10         20         30         40         50         60 
MQTIIWNHLS ETEKRKVIMR PVQQNGKNIQ QAVNAIRENV AYNGDRALFE LCEKFDGVKL 

        70         80         90        100        110        120 
DKLIVSADEI QAASSRISVK LRNAIEQAKT NIEAFHKAQQ NQEIDLEIQE GVRCQVVTRP 

       130        140        150        160        170        180 
ISCVGLYIPG GSAPLFSTVL MLAIPAKIAG CKKIVLCSPP PISDEILYTA HLCGVETIYA 

       190        200        210        220        230        240 
IGGAQAVFAM AQGTESVAKV DKIFGPGNAF VTEAKRQVAQ NSTAIDMPAG PSEVLVIADE 

       250        260        270        280        290        300 
SADPEFVASD LLSQAEHGAD SQVILVATCE TLAKETALAI ERQLALLPRA ETVRKALNHS 

       310        320        330        340        350        360 
RIFIAESLEQ AVEISNEYAP EHLIVQTKNA RKLLPYLDNA GSIFLGAYSP ESMGDYASGT 

       370        380        390        400        410        420 
NHVLPTYGYT KTYSSLGLAD FSKRMTVQEL TPKGFKNLAE TVEVMAEAEQ LAAHKMAVSV 


RLAKLNI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22128.1.
PIRA64008.
RefSeqNP_438630.1. NC_000907.1.

3D structure databases

ProteinModelPortalP44001.
SMRP44001. Positions 4-425.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949557.
GenomeReviewsGene locus HI_0469 in contig L42023_GR.
KEGGhin:HI0469.
NMPDRfig|71421.1.peg.443.
PATRIC20189493. VBIHaeInf48452_0489.
TIGRHI_0469.

Phylogenomic databases

HOGENOMHBG329596.
OMANRYVTEA.
PhylomeDBP44001.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycHINF71421:HI_0469-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_HAEIN
AccessionPrimary (citable) accession number: P44001
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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