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P44001

- HISX_HAEIN

UniProt

P44001 - HISX_HAEIN

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADBy similarity
Binding sitei185 – 1851NADBy similarity
Binding sitei208 – 2081NADBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Metal bindingi254 – 2541ZincBy similarity
Binding sitei254 – 2541SubstrateBy similarity
Metal bindingi257 – 2571ZincBy similarity
Binding sitei257 – 2571SubstrateBy similarity
Active sitei321 – 3211Proton acceptorBy similarity
Active sitei322 – 3221Proton acceptorBy similarity
Binding sitei322 – 3221SubstrateBy similarity
Metal bindingi355 – 3551ZincBy similarity
Binding sitei355 – 3551SubstrateBy similarity
Binding sitei409 – 4091SubstrateBy similarity
Metal bindingi414 – 4141ZincBy similarity
Binding sitei414 – 4141SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:HI_0469
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenasePRO_0000135777Add
BLAST

Proteomic databases

PRIDEiP44001.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0469.

Structurei

3D structure databases

ProteinModelPortaliP44001.
SMRiP44001. Positions 4-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.
PhylomeDBiP44001.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P44001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTIIWNHLS ETEKRKVIMR PVQQNGKNIQ QAVNAIRENV AYNGDRALFE
60 70 80 90 100
LCEKFDGVKL DKLIVSADEI QAASSRISVK LRNAIEQAKT NIEAFHKAQQ
110 120 130 140 150
NQEIDLEIQE GVRCQVVTRP ISCVGLYIPG GSAPLFSTVL MLAIPAKIAG
160 170 180 190 200
CKKIVLCSPP PISDEILYTA HLCGVETIYA IGGAQAVFAM AQGTESVAKV
210 220 230 240 250
DKIFGPGNAF VTEAKRQVAQ NSTAIDMPAG PSEVLVIADE SADPEFVASD
260 270 280 290 300
LLSQAEHGAD SQVILVATCE TLAKETALAI ERQLALLPRA ETVRKALNHS
310 320 330 340 350
RIFIAESLEQ AVEISNEYAP EHLIVQTKNA RKLLPYLDNA GSIFLGAYSP
360 370 380 390 400
ESMGDYASGT NHVLPTYGYT KTYSSLGLAD FSKRMTVQEL TPKGFKNLAE
410 420
TVEVMAEAEQ LAAHKMAVSV RLAKLNI
Length:427
Mass (Da):46,339
Last modified:November 1, 1995 - v1
Checksum:iFC5C5D8675654462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22128.1.
PIRiA64008.
RefSeqiNP_438630.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22128; AAC22128; HI_0469.
GeneIDi949557.
KEGGihin:HI0469.
PATRICi20189493. VBIHaeInf48452_0489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22128.1 .
PIRi A64008.
RefSeqi NP_438630.1. NC_000907.1.

3D structure databases

ProteinModelPortali P44001.
SMRi P44001. Positions 4-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0469.

Proteomic databases

PRIDEi P44001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22128 ; AAC22128 ; HI_0469 .
GeneIDi 949557.
KEGGi hin:HI0469.
PATRICi 20189493. VBIHaeInf48452_0489.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.
PhylomeDBi P44001.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiHISX_HAEIN
AccessioniPrimary (citable) accession number: P44001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3