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P44001

- HISX_HAEIN

UniProt

P44001 - HISX_HAEIN

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADBy similarity
    Binding sitei185 – 1851NADBy similarity
    Binding sitei208 – 2081NADBy similarity
    Binding sitei232 – 2321SubstrateBy similarity
    Metal bindingi254 – 2541ZincBy similarity
    Binding sitei254 – 2541SubstrateBy similarity
    Metal bindingi257 – 2571ZincBy similarity
    Binding sitei257 – 2571SubstrateBy similarity
    Active sitei321 – 3211Proton acceptorBy similarity
    Active sitei322 – 3221Proton acceptorBy similarity
    Binding sitei322 – 3221SubstrateBy similarity
    Metal bindingi355 – 3551ZincBy similarity
    Binding sitei355 – 3551SubstrateBy similarity
    Binding sitei409 – 4091SubstrateBy similarity
    Metal bindingi414 – 4141ZincBy similarity
    Binding sitei414 – 4141SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:HI_0469
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Histidinol dehydrogenasePRO_0000135777Add
    BLAST

    Proteomic databases

    PRIDEiP44001.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0469.

    Structurei

    3D structure databases

    ProteinModelPortaliP44001.
    SMRiP44001. Positions 4-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiP44001.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P44001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTIIWNHLS ETEKRKVIMR PVQQNGKNIQ QAVNAIRENV AYNGDRALFE    50
    LCEKFDGVKL DKLIVSADEI QAASSRISVK LRNAIEQAKT NIEAFHKAQQ 100
    NQEIDLEIQE GVRCQVVTRP ISCVGLYIPG GSAPLFSTVL MLAIPAKIAG 150
    CKKIVLCSPP PISDEILYTA HLCGVETIYA IGGAQAVFAM AQGTESVAKV 200
    DKIFGPGNAF VTEAKRQVAQ NSTAIDMPAG PSEVLVIADE SADPEFVASD 250
    LLSQAEHGAD SQVILVATCE TLAKETALAI ERQLALLPRA ETVRKALNHS 300
    RIFIAESLEQ AVEISNEYAP EHLIVQTKNA RKLLPYLDNA GSIFLGAYSP 350
    ESMGDYASGT NHVLPTYGYT KTYSSLGLAD FSKRMTVQEL TPKGFKNLAE 400
    TVEVMAEAEQ LAAHKMAVSV RLAKLNI 427
    Length:427
    Mass (Da):46,339
    Last modified:November 1, 1995 - v1
    Checksum:iFC5C5D8675654462
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22128.1.
    PIRiA64008.
    RefSeqiNP_438630.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22128; AAC22128; HI_0469.
    GeneIDi949557.
    KEGGihin:HI0469.
    PATRICi20189493. VBIHaeInf48452_0489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22128.1 .
    PIRi A64008.
    RefSeqi NP_438630.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P44001.
    SMRi P44001. Positions 4-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0469.

    Proteomic databases

    PRIDEi P44001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22128 ; AAC22128 ; HI_0469 .
    GeneIDi 949557.
    KEGGi hin:HI0469.
    PATRICi 20189493. VBIHaeInf48452_0489.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi P44001.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiHISX_HAEIN
    AccessioniPrimary (citable) accession number: P44001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3