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Protein

Carboxy-S-adenosyl-L-methionine synthase

Gene

cmoA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).UniRule annotation

Catalytic activityi

Prephenate + S-adenosyl-L-methionine = phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38S-adenosyl-L-methionineUniRule annotation1 Publication1
Binding sitei131S-adenosyl-L-methionineUniRule annotation1 Publication1
Binding sitei198S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-336-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxy-S-adenosyl-L-methionine synthaseUniRule annotation (EC:2.1.3.-UniRule annotation)
Short name:
Cx-SAM synthaseUniRule annotation
Gene namesi
Name:cmoAUniRule annotation
Ordered Locus Names:HI_0319
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03423 S-Adenosyl-L-Homoselenocysteine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001690841 – 241Carboxy-S-adenosyl-L-methionine synthaseAdd BLAST241

Proteomic databases

PRIDEiP43985

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi71421.HI0319

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 34Combined sources14
Helixi38 – 52Combined sources15
Beta strandi58 – 63Combined sources6
Helixi68 – 75Combined sources8
Beta strandi83 – 87Combined sources5
Helixi91 – 102Combined sources12
Beta strandi110 – 113Combined sources4
Turni117 – 119Combined sources3
Beta strandi124 – 132Combined sources9
Helixi134 – 136Combined sources3
Helixi139 – 141Combined sources3
Helixi142 – 152Combined sources11
Beta strandi153 – 164Combined sources12
Helixi170 – 186Combined sources17
Helixi189 – 191Combined sources3
Helixi195 – 204Combined sources10
Helixi210 – 220Combined sources11
Beta strandi223 – 231Combined sources9
Beta strandi234 – 240Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM8X-ray2.20A/B1-241[»]
ProteinModelPortaliP43985
SMRiP43985
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43985

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 65S-adenosyl-L-methionine bindingUniRule annotation1 Publication3
Regioni88 – 89S-adenosyl-L-methionine bindingUniRule annotation1 Publication2
Regioni116 – 117S-adenosyl-L-methionine bindingUniRule annotation1 Publication2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DA6 Bacteria
COG0500 LUCA
KOiK15256
OMAiMIELYYL
PhylomeDBiP43985

Family and domain databases

HAMAPiMF_01589 Cx_SAM_synthase, 1 hit
InterProiView protein in InterPro
IPR005271 CmoA
IPR029063 SAM-dependent_MTases
PANTHERiPTHR43861:SF2 PTHR43861:SF2, 1 hit
PIRSFiPIRSF006325 MeTrfase_bac, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00740 TIGR00740, 1 hit

Sequencei

Sequence statusi: Complete.

P43985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKDTLFSTP IAKLGDFIFD ENVAEVFPDM IQRSVPGYSN IITAIGMLAE
60 70 80 90 100
RFVTADSNVY DLGCSRGAAT LSARRNINQP NVKIIGIDNS QPMVERCRQH
110 120 130 140 150
IAAYHSEIPV EILCNDIRHV EIKNASMVIL NFTLQFLPPE DRIALLTKIY
160 170 180 190 200
EGLNPNGVLV LSEKFRFEDT KINHLLIDLH HQFKRANGYS ELEVSQKRTA
210 220 230 240
LENVMRTDSI ETHKVRLKNV GFSQVELWFQ CFNFGSMIAV K
Length:241
Mass (Da):27,372
Last modified:November 1, 1995 - v1
Checksum:i08743633A3E853F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21983.1
PIRiC64006
RefSeqiNP_438485.1, NC_000907.1
WP_005694346.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21983; AAC21983; HI_0319
GeneIDi949432
KEGGihin:HI0319
PATRICifig|71421.8.peg.337

Similar proteinsi

Entry informationi

Entry nameiCMOA_HAEIN
AccessioniPrimary (citable) accession number: P43985
Secondary accession number(s): P43986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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