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P43948

- MPL_HAEIN

UniProt

P43948 - MPL_HAEIN

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Protein

UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase

Gene

mpl

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1177ATPSequence Analysis

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-UniPathway
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (EC:6.3.2.-)
Alternative name(s):
Murein peptide ligase
Gene namesi
Name:mpl
Ordered Locus Names:HI_0121
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligasePRO_0000101709Add
BLAST

Proteomic databases

PRIDEiP43948.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0121.

Structurei

3D structure databases

ProteinModelPortaliP43948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.Curated

Phylogenomic databases

eggNOGiCOG0773.
KOiK02558.
OMAiAWILEDC.
OrthoDBiEOG64BQ73.
PhylomeDBiP43948.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005757. Murein_peptide_ligase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01081. mpl. 1 hit.

Sequencei

Sequence statusi: Complete.

P43948-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHIHILGIC GTFMGGVAMI AKQMGYHVTG SDTNVYPPMS TFLEEQGIEI
60 70 80 90 100
IPNYDVAQLQ PAPDMVIVGN AMKRGNPCVE YVLENNLKYT SGPQWLHDHL
110 120 130 140 150
LRDRWVLAVS GTHGKTTTTG MLTWVLEQNG LKSGFLIGGI AGNFGISARL
160 170 180 190 200
GDSPYFIIEA DEYDTAFFDK RSKFVHYNPR TLIVNNISFD HADIFDDLKA
210 220 230 240 250
IQRQFHHMIR TIPASGLVLS SASEQSAKET LALGCWSQQQ FLGKDNEWFA
260 270 280 290 300
ERITNDASHF AVFHHGEKVA EVKWNVVGQH NMHNALMAIA AAHHTGVAIE
310 320 330 340 350
DACKALGSFV NAKRRLEVKG EVNSITVYDD FAHHPEAILA TLTALRDKVG
360 370 380 390 400
GGVRILAVLE PRSNTMKMGV HKDDIAPALG RADAVFMLQP EQLSWEVADI
410 420 430 440 450
ANQCVQPAYW NANLDRLVDM IVAKAQPTDH ILVMSNGSFG GIHQKILDKL

KLK
Length:453
Mass (Da):50,074
Last modified:November 1, 1995 - v1
Checksum:i5E7E71A07646EB7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21795.1.
PIRiB64002.
RefSeqiNP_438293.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21795; AAC21795; HI_0121.
GeneIDi951026.
KEGGihin:HI0121.
PATRICi20188727. VBIHaeInf48452_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21795.1 .
PIRi B64002.
RefSeqi NP_438293.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43948.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0121.

Proteomic databases

PRIDEi P43948.

Protocols and materials databases

DNASUi 951026.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21795 ; AAC21795 ; HI_0121 .
GeneIDi 951026.
KEGGi hin:HI0121.
PATRICi 20188727. VBIHaeInf48452_0125.

Phylogenomic databases

eggNOGi COG0773.
KOi K02558.
OMAi AWILEDC.
OrthoDBi EOG64BQ73.
PhylomeDBi P43948.

Enzyme and pathway databases

UniPathwayi UPA00544 .

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005757. Murein_peptide_ligase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01081. mpl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMPL_HAEIN
AccessioniPrimary (citable) accession number: P43948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3