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P43948 (MPL_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase

EC=6.3.2.-
Alternative name(s):
Murein peptide ligase
Gene names
Name:mpl
Ordered Locus Names:HI_0121
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid.

Pathway

Cell wall biogenesis; peptidoglycan recycling.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
PRO_0000101709

Regions

Nucleotide binding111 – 1177ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P43948 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5E7E71A07646EB7D

FASTA45350,074
        10         20         30         40         50         60 
MKHIHILGIC GTFMGGVAMI AKQMGYHVTG SDTNVYPPMS TFLEEQGIEI IPNYDVAQLQ 

        70         80         90        100        110        120 
PAPDMVIVGN AMKRGNPCVE YVLENNLKYT SGPQWLHDHL LRDRWVLAVS GTHGKTTTTG 

       130        140        150        160        170        180 
MLTWVLEQNG LKSGFLIGGI AGNFGISARL GDSPYFIIEA DEYDTAFFDK RSKFVHYNPR 

       190        200        210        220        230        240 
TLIVNNISFD HADIFDDLKA IQRQFHHMIR TIPASGLVLS SASEQSAKET LALGCWSQQQ 

       250        260        270        280        290        300 
FLGKDNEWFA ERITNDASHF AVFHHGEKVA EVKWNVVGQH NMHNALMAIA AAHHTGVAIE 

       310        320        330        340        350        360 
DACKALGSFV NAKRRLEVKG EVNSITVYDD FAHHPEAILA TLTALRDKVG GGVRILAVLE 

       370        380        390        400        410        420 
PRSNTMKMGV HKDDIAPALG RADAVFMLQP EQLSWEVADI ANQCVQPAYW NANLDRLVDM 

       430        440        450 
IVAKAQPTDH ILVMSNGSFG GIHQKILDKL KLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21795.1.
PIRB64002.
RefSeqNP_438293.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43948.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0121.

Proteomic databases

PRIDEP43948.

Protocols and materials databases

DNASU951026.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21795; AAC21795; HI_0121.
GeneID951026.
KEGGhin:HI0121.
PATRIC20188727. VBIHaeInf48452_0125.

Phylogenomic databases

eggNOGCOG0773.
KOK02558.
OMAAWILEDC.
OrthoDBEOG64BQ73.
PhylomeDBP43948.

Enzyme and pathway databases

UniPathwayUPA00544.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005757. Murein_peptide_ligase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01081. mpl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPL_HAEIN
AccessionPrimary (citable) accession number: P43948
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names