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P43948

- MPL_HAEIN

UniProt

P43948 - MPL_HAEIN

Protein

UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase

Gene

mpl

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi111 – 1177ATPSequence Analysis

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. cell wall organization Source: InterPro
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-UniPathway
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (EC:6.3.2.-)
    Alternative name(s):
    Murein peptide ligase
    Gene namesi
    Name:mpl
    Ordered Locus Names:HI_0121
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligasePRO_0000101709Add
    BLAST

    Proteomic databases

    PRIDEiP43948.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0121.

    Structurei

    3D structure databases

    ProteinModelPortaliP43948.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.Curated

    Phylogenomic databases

    eggNOGiCOG0773.
    KOiK02558.
    OMAiAWILEDC.
    OrthoDBiEOG64BQ73.
    PhylomeDBiP43948.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005757. Murein_peptide_ligase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01081. mpl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43948-1 [UniParc]FASTAAdd to Basket

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    MKHIHILGIC GTFMGGVAMI AKQMGYHVTG SDTNVYPPMS TFLEEQGIEI    50
    IPNYDVAQLQ PAPDMVIVGN AMKRGNPCVE YVLENNLKYT SGPQWLHDHL 100
    LRDRWVLAVS GTHGKTTTTG MLTWVLEQNG LKSGFLIGGI AGNFGISARL 150
    GDSPYFIIEA DEYDTAFFDK RSKFVHYNPR TLIVNNISFD HADIFDDLKA 200
    IQRQFHHMIR TIPASGLVLS SASEQSAKET LALGCWSQQQ FLGKDNEWFA 250
    ERITNDASHF AVFHHGEKVA EVKWNVVGQH NMHNALMAIA AAHHTGVAIE 300
    DACKALGSFV NAKRRLEVKG EVNSITVYDD FAHHPEAILA TLTALRDKVG 350
    GGVRILAVLE PRSNTMKMGV HKDDIAPALG RADAVFMLQP EQLSWEVADI 400
    ANQCVQPAYW NANLDRLVDM IVAKAQPTDH ILVMSNGSFG GIHQKILDKL 450
    KLK 453
    Length:453
    Mass (Da):50,074
    Last modified:November 1, 1995 - v1
    Checksum:i5E7E71A07646EB7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21795.1.
    PIRiB64002.
    RefSeqiNP_438293.1. NC_000907.1.
    WP_005694412.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21795; AAC21795; HI_0121.
    GeneIDi951026.
    KEGGihin:HI0121.
    PATRICi20188727. VBIHaeInf48452_0125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21795.1 .
    PIRi B64002.
    RefSeqi NP_438293.1. NC_000907.1.
    WP_005694412.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43948.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0121.

    Proteomic databases

    PRIDEi P43948.

    Protocols and materials databases

    DNASUi 951026.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21795 ; AAC21795 ; HI_0121 .
    GeneIDi 951026.
    KEGGi hin:HI0121.
    PATRICi 20188727. VBIHaeInf48452_0125.

    Phylogenomic databases

    eggNOGi COG0773.
    KOi K02558.
    OMAi AWILEDC.
    OrthoDBi EOG64BQ73.
    PhylomeDBi P43948.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005757. Murein_peptide_ligase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01081. mpl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiMPL_HAEIN
    AccessioniPrimary (citable) accession number: P43948
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3