P43930 (Y042_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized RNA pseudouridine synthase HI_0042
EC=5.4.99.-

Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase

Gene names

Ordered Locus Names:

HI_0042

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	RNA uridine = RNA pseudouridine.
Sequence similarities	Belongs to the pseudouridine synthase rluA family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Uncharacterized RNA pseudouridine synthase HI_0042		PRO_0000162726
Sites
	Active site	52	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43930 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1EE581956D0E41BD	FASTA	224	25,526
	10 20 30 40 50 60 MEIEVVYQHS DFIIINKSEG ISVHKDQEEQ GLTELVAKQL NVPKVWLVHR LDKVTSGLLI 70 80 90 100 110 120 LALNAESAAE FSRLFSEHKI HKTYLALSNQ KPKKKQGLII GDMKKAREGA WKLCQTKDNP 130 140 150 160 170 180 AITRFESVSC EPNLRLFILK PQTGKTHQLR VAMKSLGSPI LGDGLYGKNT EKIDRTYLHA 190 200 210 220 TQLEFDYLNN FISVTCLPSQ GQFWIKPTVF EQIQVYLTKP FLSK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21720.1.
PIR	B64000.
RefSeq	NP_438215.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43930.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950939.
GenomeReviews	Gene locus HI_0042 in contig L42023_GR.
KEGG	hin:HI0042.
NMPDR	fig|71421.1.peg.41.
PATRIC	20188535. VBIHaeInf48452_0042.
TIGR	HI_0042.
Phylogenomic databases
HOGENOM	HBG750656.
OMA	HFRYQHE.
ProtClustDB	CLSK2299231.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0042-MONOMER.
Family and domain databases
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR006508. PsdUridine_synth_RluA-like. IPR006224. PsdUridine_synth_RluC/D_CS. IPR006145. PsdUridine_synth_RsuA/RluD. [Graphical view]
KO	K06177.
Pfam	PF00849. PseudoU_synth_2. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
TIGRFAMs	TIGR01621. RluA-like. 1 hit.
PROSITE	PS01129. PSI_RLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y042_HAEIN

Accession

Primary (citable) accession number: P43930

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program