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P43924

- KPYK_HAEIN

UniProt

P43924 - KPYK_HAEIN

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Protein
Pyruvate kinase
Gene
pykA, HI_1573
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Enzyme regulationi

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Metal bindingi38 – 381Potassium By similarity
Metal bindingi40 – 401Potassium By similarity
Metal bindingi70 – 701Potassium By similarity
Sitei223 – 2231Transition state stabilizer By similarity
Metal bindingi225 – 2251Magnesium By similarity
Binding sitei251 – 2511Substrate; via amide nitrogen By similarity
Metal bindingi252 – 2521Magnesium By similarity
Binding sitei252 – 2521Substrate; via amide nitrogen By similarity
Binding sitei284 – 2841Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pykA
Ordered Locus Names:HI_1573
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 478477Pyruvate kinase
PRO_0000112075Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi71421.HI1573.

Structurei

3D structure databases

ProteinModelPortaliP43924.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
KOiK00873.
OMAiTPVYFDS.
OrthoDBiEOG6GBMB0.
PhylomeDBiP43924.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43924-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRLRRTKI VCTMGPSTDR DNNLEKIIAA GANVVRMNFS HGTPDDHIGR    50
AERVRSIAKK LGKTVAILGD LQGPKIRVST FKDGKIFLNV GDKFILDAEL 100
PKGEGTQESV GLDYKTLPQD VVPGDILLLD DGRVQLKVLS TDGAKVFTEV 150
TVGGPLSNNK GINKLGGGLS ADALTEKDKA DIITAARIGV DFLAVSFPRS 200
SADLNYAREL AQQAGLNAKI VAKVERAETV ANDEAMDDII LASDVIMVAR 250
GDLGVEIGDP ELVGVQKKLI RRSRQLNRAV ITATQMMESM ISNPMPTRAE 300
VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMASVCLG AEKMPSINVS 350
RHRMDKEFET IEESVAMSAM YAANHMKGVA AIVTLSSTGR TPLLMSRISS 400
GLPIFALSRN QETLNLCALY RGVTPIYHGE ESRTEAGAKA APQSLKEKGY 450
LSTGDLVLVT QGGQGATQTN VCRTLIVE 478
Length:478
Mass (Da):51,055
Last modified:January 23, 2007 - v2
Checksum:iFF803EC3E3BD6216
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23216.1.
PIRiC64130.
RefSeqiNP_439719.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23216; AAC23216; HI_1573.
GeneIDi950433.
KEGGihin:HI1573.
PATRICi20191875. VBIHaeInf48452_1645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23216.1 .
PIRi C64130.
RefSeqi NP_439719.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23216 ; AAC23216 ; HI_1573 .
GeneIDi 950433.
KEGGi hin:HI1573.
PATRICi 20191875. VBIHaeInf48452_1645.

Phylogenomic databases

eggNOGi COG0469.
KOi K00873.
OMAi TPVYFDS.
OrthoDBi EOG6GBMB0.
PhylomeDBi P43924.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiKPYK_HAEIN
AccessioniPrimary (citable) accession number: P43924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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