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P43924 (KPYK_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pykA
Ordered Locus Names:HI_1573
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Enzyme regulation

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 478477Pyruvate kinase
PRO_0000112075

Sites

Metal binding381Potassium By similarity
Metal binding401Potassium By similarity
Metal binding701Potassium By similarity
Metal binding2251Magnesium By similarity
Metal binding2521Magnesium By similarity
Binding site361Substrate By similarity
Binding site2511Substrate; via amide nitrogen By similarity
Binding site2521Substrate; via amide nitrogen By similarity
Binding site2841Substrate By similarity
Site2231Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P43924 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: FF803EC3E3BD6216

FASTA47851,055
        10         20         30         40         50         60 
MSRRLRRTKI VCTMGPSTDR DNNLEKIIAA GANVVRMNFS HGTPDDHIGR AERVRSIAKK 

        70         80         90        100        110        120 
LGKTVAILGD LQGPKIRVST FKDGKIFLNV GDKFILDAEL PKGEGTQESV GLDYKTLPQD 

       130        140        150        160        170        180 
VVPGDILLLD DGRVQLKVLS TDGAKVFTEV TVGGPLSNNK GINKLGGGLS ADALTEKDKA 

       190        200        210        220        230        240 
DIITAARIGV DFLAVSFPRS SADLNYAREL AQQAGLNAKI VAKVERAETV ANDEAMDDII 

       250        260        270        280        290        300 
LASDVIMVAR GDLGVEIGDP ELVGVQKKLI RRSRQLNRAV ITATQMMESM ISNPMPTRAE 

       310        320        330        340        350        360 
VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMASVCLG AEKMPSINVS RHRMDKEFET 

       370        380        390        400        410        420 
IEESVAMSAM YAANHMKGVA AIVTLSSTGR TPLLMSRISS GLPIFALSRN QETLNLCALY 

       430        440        450        460        470 
RGVTPIYHGE ESRTEAGAKA APQSLKEKGY LSTGDLVLVT QGGQGATQTN VCRTLIVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23216.1.
PIRC64130.
RefSeqNP_439719.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43924.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1573.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23216; AAC23216; HI_1573.
GeneID950433.
KEGGhin:HI1573.
PATRIC20191875. VBIHaeInf48452_1645.

Phylogenomic databases

eggNOGCOG0469.
KOK00873.
OMATPVYFDS.
OrthoDBEOG6GBMB0.
PhylomeDBP43924.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_HAEIN
AccessionPrimary (citable) accession number: P43924
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names