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P43924

- KPYK_HAEIN

UniProt

P43924 - KPYK_HAEIN

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Protein

Pyruvate kinase

Gene

pykA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.By similarity
Potassium.By similarity

Enzyme regulationi

Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Metal bindingi38 – 381PotassiumBy similarity
Metal bindingi40 – 401PotassiumBy similarity
Metal bindingi70 – 701PotassiumBy similarity
Sitei223 – 2231Transition state stabilizerBy similarity
Metal bindingi225 – 2251MagnesiumBy similarity
Binding sitei251 – 2511Substrate; via amide nitrogenBy similarity
Metal bindingi252 – 2521MagnesiumBy similarity
Binding sitei252 – 2521Substrate; via amide nitrogenBy similarity
Binding sitei284 – 2841SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pykA
Ordered Locus Names:HI_1573
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 478477Pyruvate kinasePRO_0000112075Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1573.

Structurei

3D structure databases

ProteinModelPortaliP43924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0469.
KOiK00873.
OMAiTPVYFDS.
OrthoDBiEOG6GBMB0.
PhylomeDBiP43924.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43924-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRLRRTKI VCTMGPSTDR DNNLEKIIAA GANVVRMNFS HGTPDDHIGR
60 70 80 90 100
AERVRSIAKK LGKTVAILGD LQGPKIRVST FKDGKIFLNV GDKFILDAEL
110 120 130 140 150
PKGEGTQESV GLDYKTLPQD VVPGDILLLD DGRVQLKVLS TDGAKVFTEV
160 170 180 190 200
TVGGPLSNNK GINKLGGGLS ADALTEKDKA DIITAARIGV DFLAVSFPRS
210 220 230 240 250
SADLNYAREL AQQAGLNAKI VAKVERAETV ANDEAMDDII LASDVIMVAR
260 270 280 290 300
GDLGVEIGDP ELVGVQKKLI RRSRQLNRAV ITATQMMESM ISNPMPTRAE
310 320 330 340 350
VMDVANAVLD GTDAVMLSAE TAAGQYPSET VAAMASVCLG AEKMPSINVS
360 370 380 390 400
RHRMDKEFET IEESVAMSAM YAANHMKGVA AIVTLSSTGR TPLLMSRISS
410 420 430 440 450
GLPIFALSRN QETLNLCALY RGVTPIYHGE ESRTEAGAKA APQSLKEKGY
460 470
LSTGDLVLVT QGGQGATQTN VCRTLIVE
Length:478
Mass (Da):51,055
Last modified:January 23, 2007 - v2
Checksum:iFF803EC3E3BD6216
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23216.1.
PIRiC64130.
RefSeqiNP_439719.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23216; AAC23216; HI_1573.
GeneIDi950433.
KEGGihin:HI1573.
PATRICi20191875. VBIHaeInf48452_1645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23216.1 .
PIRi C64130.
RefSeqi NP_439719.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23216 ; AAC23216 ; HI_1573 .
GeneIDi 950433.
KEGGi hin:HI1573.
PATRICi 20191875. VBIHaeInf48452_1645.

Phylogenomic databases

eggNOGi COG0469.
KOi K00873.
OMAi TPVYFDS.
OrthoDBi EOG6GBMB0.
PhylomeDBi P43924.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiKPYK_HAEIN
AccessioniPrimary (citable) accession number: P43924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3