P43911 (SELD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenide, water dikinase
EC=2.7.9.3

Alternative name(s):
Selenium donor protein
Selenophosphate synthase

Gene names

Name:	selD
Ordered Locus Names:	HI_0200

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity. HAMAP MF_00625
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity. HAMAP MF_00625
Sequence similarities	Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Sequence caution	The sequence AAC21869.1 differs from that shown. Reason: Erroneous termination at position 16. Translated as Sec.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Selenide, water dikinase HAMAP MF_00625		PRO_0000127627
Regions
	Nucleotide binding	229 – 235	7	ATP Potential
Sites
	Active site	16	1	Potential
	Site	19	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	16	1	Selenocysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P43911 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: AFDD459A74D783F7	FASTA	346	36,400
	10 20 30 40 50 60 MEEKIRLTQY SHGAGUGCKI SPKVLGTILH SELEKFYDPN LIVGNETADD AAVYDLGNGT 70 80 90 100 110 120 AIISTTDFFM PIVDDPFDFG RIAATNAISD IFAMGGKPIM GIAILGFPTN VLPAEVAQKI 130 140 150 160 170 180 VDGGRFACHQ AGIALAGGHS IDSPEPIFGL AVTGVIDTEK VKRNASAKSG CKLYMTKPLG 190 200 210 220 230 240 IGILTTAEKK GKLKPEHQGL ATAAMCQMNS IGSQFSQVDG VTAMTDVTGF GLLGHLIEIC 250 260 270 280 290 300 EGSNLSAVVF SDKIKTLDGV KDYIAQGCVP GGTGRNFDSY GHKVGILTEE QKAILCDPQT 310 320 330 340 SGGLLVAVEL NSVQTVIDIA KDAGIDLYEV GKLKPKSESD IVVEVK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21869.1. Sequence problems.
PIR	A64054.
RefSeq	NP_438369.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43911.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	951109.
GenomeReviews	Gene locus HI_0200 in contig L42023_GR.
PATRIC	20188897. VBIHaeInf48452_0205.
TIGR	HI_0200.
Phylogenomic databases
HOGENOM	HBG383791.
OMA	DYIAQGC.
ProtClustDB	PRK00943.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0200-MONOMER.
Family and domain databases
HAMAP	MF_00625. SelD. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. IPR023061. SelD_I. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00476. SelD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_HAEIN

Accession

Primary (citable) accession number: P43911

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program